6J6N
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![BU of 6j6n by Molmil](/molmil-images/mine/6j6n) | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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6J6Q
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![BU of 6j6q by Molmil](/molmil-images/mine/6j6q) | Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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4GNF
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![BU of 4gnf by Molmil](/molmil-images/mine/4gnf) | Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-15 | Descriptor: | Histone H3.3, Histone-lysine N-methyltransferase NSD3, ZINC ION | Authors: | Li, F, He, C, Wu, J, Shi, Y. | Deposit date: | 2012-08-17 | Release date: | 2013-01-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition. J.Biol.Chem., 288, 2013
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4GNG
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![BU of 4gng by Molmil](/molmil-images/mine/4gng) | Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3K9me3 peptide | Descriptor: | GLYCEROL, Histone H3.3, Histone-lysine N-methyltransferase NSD3, ... | Authors: | Li, F, He, C, Wu, J, Shi, Y. | Deposit date: | 2012-08-17 | Release date: | 2013-01-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition. J.Biol.Chem., 288, 2013
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4GXL
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![BU of 4gxl by Molmil](/molmil-images/mine/4gxl) | The crystal structure of Galectin-8 C-CRD in complex with NDP52 | Descriptor: | GLYCEROL, Galectin-8, Peptide from Calcium-binding and coiled-coil domain-containing protein 2 | Authors: | Li, S, Wandel, M.P, Li, F, Liu, Z, He, C, Wu, J, Shi, Y, Randow, F. | Deposit date: | 2012-09-04 | Release date: | 2013-05-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.023 Å) | Cite: | Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy Sci.Signal., 6, 2013
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4KDM
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![BU of 4kdm by Molmil](/molmil-images/mine/4kdm) | Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | Authors: | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | Deposit date: | 2013-04-25 | Release date: | 2013-07-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.496 Å) | Cite: | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell, 4, 2013
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6JCG
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![BU of 6jcg by Molmil](/molmil-images/mine/6jcg) | Room temperature structure of HIV-1 Integrase catalytic core domain by serial femtosecond crystallography. | Descriptor: | CACODYLATE ION, Integrase | Authors: | Park, J.H, Shi, Y, Han, J, Li, X, Kim, T.H, Yun, J.H. | Deposit date: | 2019-01-28 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Non-Cryogenic Structure and Dynamics of HIV-1 Integrase Catalytic Core Domain by X-ray Free-Electron Lasers. Int J Mol Sci, 20, 2019
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4KDQ
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![BU of 4kdq by Molmil](/molmil-images/mine/4kdq) | Crystal structure of the hemagglutinin of A/Xinjiang/1/2006 virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | Authors: | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | Deposit date: | 2013-04-25 | Release date: | 2013-07-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell, 4, 2013
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4M37
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![BU of 4m37 by Molmil](/molmil-images/mine/4m37) | |
4M75
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![BU of 4m75 by Molmil](/molmil-images/mine/4m75) | Crystal structure of Lsm1-7 complex | Descriptor: | CHLORIDE ION, U6 snRNA-associated Sm-like protein Lsm1, U6 snRNA-associated Sm-like protein Lsm2, ... | Authors: | Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. | Deposit date: | 2013-08-12 | Release date: | 2013-10-23 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506, 2014
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4GND
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![BU of 4gnd by Molmil](/molmil-images/mine/4gnd) | Crystal Structure of NSD3 tandem PHD5-C5HCH domains | Descriptor: | Histone-lysine N-methyltransferase NSD3, ZINC ION | Authors: | Li, F, He, C, Wu, J, Shi, Y. | Deposit date: | 2012-08-17 | Release date: | 2013-01-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition. J.Biol.Chem., 288, 2013
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4M7D
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![BU of 4m7d by Molmil](/molmil-images/mine/4m7d) | Crystal structure of Lsm2-8 complex bound to the RNA fragment CGUUU | Descriptor: | U6 snRNA, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ... | Authors: | Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. | Deposit date: | 2013-08-12 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.595 Å) | Cite: | Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506, 2014
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4M7A
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![BU of 4m7a by Molmil](/molmil-images/mine/4m7a) | Crystal structure of Lsm2-8 complex bound to the 3' end sequence of U6 snRNA | Descriptor: | U6 snRNA, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ... | Authors: | Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. | Deposit date: | 2013-08-12 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.781 Å) | Cite: | Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506, 2014
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4JUJ
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![BU of 4juj by Molmil](/molmil-images/mine/4juj) | Crystal structure of 1918 pandemic influenza virus hemagglutinin mutant D225G complexed with human receptor analogue LSTc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Zhang, W, Shi, Y, Qi, J, Gao, F, Li, Q, Fan, Z, Yan, J, Gao, G.F. | Deposit date: | 2013-03-25 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.013 Å) | Cite: | Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution J.Virol., 87, 2013
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4NN2
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![BU of 4nn2 by Molmil](/molmil-images/mine/4nn2) | Protein Crystal Structure of Human Borjeson-Forssman-Lehmann Syndrome Associated Protein PHF6 | Descriptor: | GLYCEROL, PHD finger protein 6, ZINC ION | Authors: | Liu, Z, Li, F, Zhang, J, Mei, Y, Wu, J, Shi, Y. | Deposit date: | 2013-11-16 | Release date: | 2014-02-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.472 Å) | Cite: | Crystal Structure of the second extended PHD domain of human PHF6 protein J.Biol.Chem., 2014
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4JUH
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![BU of 4juh by Molmil](/molmil-images/mine/4juh) | Crystal structure of 1918 pandemic influenza virus hemagglutinin mutant D225G complexed with avian receptor analogue LSTa | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Zhang, W, Shi, Y, Qi, J, Gao, F, Li, Q, Fan, Z, Yan, J, Gao, G.F. | Deposit date: | 2013-03-24 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution J.Virol., 87, 2013
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4KPS
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![BU of 4kps by Molmil](/molmil-images/mine/4kps) | Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, ... | Authors: | Lu, X, Qi, J, Shi, Y, Gao, G. | Deposit date: | 2013-05-14 | Release date: | 2013-07-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.587 Å) | Cite: | Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6 J.Virol., 87, 2013
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6ID0
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![BU of 6id0 by Molmil](/molmil-images/mine/6id0) | Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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6ICZ
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![BU of 6icz by Molmil](/molmil-images/mine/6icz) | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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6LR4
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![BU of 6lr4 by Molmil](/molmil-images/mine/6lr4) | Molecular basis for inhibition of human gamma-secretase by small molecule | Descriptor: | (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | Deposit date: | 2020-01-15 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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4LNP
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![BU of 4lnp by Molmil](/molmil-images/mine/4lnp) | The first SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin | Descriptor: | Sorbin and SH3 domain-containing protein 1, Vinculin | Authors: | Zhao, D, Li, F, Wu, J, Shi, Y, Zhang, Z, Gong, Q. | Deposit date: | 2013-07-11 | Release date: | 2014-05-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin J.Struct.Biol., 187, 2014
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8H6K
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![BU of 8h6k by Molmil](/molmil-images/mine/8h6k) | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2022-10-18 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8H6J
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![BU of 8h6j by Molmil](/molmil-images/mine/8h6j) | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2022-10-18 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8H6E
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![BU of 8h6e by Molmil](/molmil-images/mine/8h6e) | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2022-10-17 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8H6L
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![BU of 8h6l by Molmil](/molmil-images/mine/8h6l) | Cryo-EM structure of human exon-defined spliceosome in the early B state. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | Deposit date: | 2022-10-18 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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