4GNG

Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3K9me3 peptide

Summary for 4GNG

• Entry DOI: 10.2210/pdb4gng/pdb
• Related: 4GND 4GNE 4GNF
• Descriptor: Histone-lysine N-methyltransferase NSD3, Histone H3.3, ZINC ION, ... (5 entities in total)
• Functional Keywords: zinc finger, transcription, histone, lysine methyaltion, nuclear protein, transferase-nuclear protein complex, transferase/nuclear protein
• Biological source: Homo sapiens; More
• Cellular location: Nucleus (By similarity): Q9BZ95; Nucleus: P84243
• Total number of polymer chains: 4
• Total formula weight: 28132.89

Authors

Li, F.,He, C.,Wu, J.,Shi, Y. (deposition date: 2012-08-17, release date: 2013-01-02, Last modification date: 2023-11-08)

• Primary citation: He, C.,Li, F.,Zhang, J.,Wu, J.,Shi, Y.; The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition.; J.Biol.Chem., 288:4692-4703, 2013; PubMed: 23269674; DOI: 10.1074/jbc.M112.426148

Experimental method

X-RAY DIFFRACTION (1.73 Å)