4GNG
Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3K9me3 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | Histone-lysine N-methyltransferase NSD3 | polymer | 107 | 12058.8 | 2 | UniProt (Q9BZ95) Pfam (PF17982) | Homo sapiens | Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1 |
| 2 | B, D (B, F) | Histone H3.3 | polymer | 15 | 1607.9 | 2 | UniProt (P84243) | Homo sapiens | |
| 3 | E, F, G, H, L... (A, D) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 4 | I, J, K (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | P, Q, R, S (A, B, D, F) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, D: 1310 - 1413 (UniProt: Q9BZ95)
| PDB | External Database | Details |
|---|---|---|
| Ser 1307 | - | expression tag |
| Asn 1308 | - | expression tag |
| Ala 1309 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 27333.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 799.6 | |
| All* | Total formula weight | 28132.9 |
