2O4X
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![BU of 2o4x by Molmil](/molmil-images/mine/2o4x) | Crystal structure of human P100 tudor domain | Descriptor: | Staphylococcal nuclease domain-containing protein 1 | Authors: | Shaw, N, Zhao, M, Cheng, C, Xu, H, Yang, J, Silvennoinen, O, Rao, Z, Wang, B.C, Liu, Z.J. | Deposit date: | 2006-12-05 | Release date: | 2007-02-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of human P100 tudor domain To be Published
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4GL9
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![BU of 4gl9 by Molmil](/molmil-images/mine/4gl9) | Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain | Descriptor: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Interleukin-6 receptor subunit beta, PHOSPHATE ION, ... | Authors: | Kershaw, N.J, Murphy, J.M, Laktyushin, A, Nicola, N.A, Babon, J.J. | Deposit date: | 2012-08-14 | Release date: | 2013-03-06 | Last modified: | 2018-06-13 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat.Struct.Mol.Biol., 20, 2013
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4TXA
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![BU of 4txa by Molmil](/molmil-images/mine/4txa) | |
6C5X
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![BU of 6c5x by Molmil](/molmil-images/mine/6c5x) | Crystal Structure of SOCS1 in complex with ElonginB and ElonginC | Descriptor: | Elongin-B, Elongin-C, GP130 peptide fragment, ... | Authors: | Kershaw, N.J, Laktyushin, A, Babon, J.J. | Deposit date: | 2018-01-17 | Release date: | 2018-05-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.105 Å) | Cite: | The molecular basis of JAK/STAT inhibition by SOCS1. Nat Commun, 9, 2018
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4XBM
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![BU of 4xbm by Molmil](/molmil-images/mine/4xbm) | X-ray crystal structure of Notch ligand Delta-like 1 | Descriptor: | Delta-like protein 1, alpha-L-fucopyranose | Authors: | Kershaw, N.J, Burgess, A.W, Church, N.L, Luo, C.S, Adam, T.E. | Deposit date: | 2014-12-17 | Release date: | 2015-03-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Notch ligand delta-like1: X-ray crystal structure and binding affinity. Biochem.J., 468, 2015
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7M6T
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![BU of 7m6t by Molmil](/molmil-images/mine/7m6t) | Crystal structure of SOCS2/ElonginB/ElonginC bound to a non-canonical peptide that enhances phospho-peptide binding | Descriptor: | Elongin-B, Elongin-C, Non-canonical peptide F3, ... | Authors: | Kershaw, N.J, Li, K, Linossi, E.M, Nicholson, S.E. | Deposit date: | 2021-03-26 | Release date: | 2021-10-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.194 Å) | Cite: | Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nat Commun, 12, 2021
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6BZH
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![BU of 6bzh by Molmil](/molmil-images/mine/6bzh) | Structure of mouse RIG-I tandem CARDs | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Probable ATP-dependent RNA helicase DDX58 | Authors: | Kershaw, N.J, D'Cruz, A.A, Babon, J.J, Nicholson, S.E. | Deposit date: | 2017-12-24 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of a second binding site on the TRIM25 B30.2 domain. Biochem. J., 475, 2018
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4B8E
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![BU of 4b8e by Molmil](/molmil-images/mine/4b8e) | PRY-SPRY domain of Trim25 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN/ISG15 LIGASE TRIM25 | Authors: | Kershaw, N.J, D'Cruz, A.A, Nicola, N.A, Nicholson, S.E, Babon, J.J. | Deposit date: | 2012-08-27 | Release date: | 2013-09-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.779 Å) | Cite: | Crystal Structure of the Trim25 B30.2 (Pryspry) Domain: A Key Component of Antiviral Signaling. Biochem.J., 456, 2013
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3L5I
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![BU of 3l5i by Molmil](/molmil-images/mine/3l5i) | Crystal structure of FnIII domains of human GP130 (Domains 4-6) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Interleukin-6 receptor subunit beta | Authors: | Kershaw, N.J, Zhang, J.-G, Garrett, T.P.J, Czabotar, P.E. | Deposit date: | 2009-12-22 | Release date: | 2010-05-12 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. J.Biol.Chem., 285, 2010
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3L5J
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![BU of 3l5j by Molmil](/molmil-images/mine/3l5j) | Crystal structure of FnIII domains of human GP130 (Domains 4-6) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Interleukin-6 receptor subunit beta | Authors: | Kershaw, N.J, Zhang, J.-G, Garrett, T.P.J, Czabotar, P.E. | Deposit date: | 2009-12-22 | Release date: | 2010-05-12 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.042 Å) | Cite: | Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. J.Biol.Chem., 285, 2010
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5UCG
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![BU of 5ucg by Molmil](/molmil-images/mine/5ucg) | Structure of the PP2C Phosphatase Domain and a Fragment of the Regulatory Domain of the Cell Fate Determinant SpoIIE from Bacillus Subtilis | Descriptor: | Stage II sporulation protein E | Authors: | Bradshaw, N, Levdikov, V, Zimanyi, C, Gaudet, R, Wilkinson, A, Losick, R. | Deposit date: | 2016-12-22 | Release date: | 2017-05-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.906 Å) | Cite: | A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases. Elife, 6, 2017
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6MW7
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![BU of 6mw7 by Molmil](/molmil-images/mine/6mw7) | Crystal structure of ATPase module of SMCHD1 bound to ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SODIUM ION, ... | Authors: | Pedersen, L.C, Inoue, K, Kim, S, Perera, L, Shaw, N.D. | Deposit date: | 2018-10-29 | Release date: | 2019-09-11 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1. Commun Biol, 2, 2019
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3C0F
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![BU of 3c0f by Molmil](/molmil-images/mine/3c0f) | Crystal Structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source | Descriptor: | Uncharacterized protein AF_1514 | Authors: | Li, Y, Bahti, P, Shaw, N, Song, G, Yin, J, Zhu, J.-Y, Zhang, H, Xu, H, Wang, B.-C, Liu, Z.-J. | Deposit date: | 2008-01-20 | Release date: | 2008-02-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Proteins, 71, 2008
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4X2Z
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![BU of 4x2z by Molmil](/molmil-images/mine/4x2z) | Structural view and substrate specificity of papain-like protease from Avian Infectious Bronchitis Virus | Descriptor: | Nonstructural protein 3, ZINC ION | Authors: | Kong, L, Shaw, N, Yan, L, Lou, Z, Rao, Z. | Deposit date: | 2014-11-27 | Release date: | 2015-01-28 | Last modified: | 2015-04-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus. J.Biol.Chem., 290, 2015
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4R3D
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![BU of 4r3d by Molmil](/molmil-images/mine/4r3d) | Crystal structure of MERS Coronavirus papain like protease | Descriptor: | Non-structural protein 3, ZINC ION | Authors: | Kong, L.Y, Wang, Q, Ming, Z.H, Shaw, N, Sun, Y.N, Yan, L.M, Lou, Z.Y, Rao, Z.H. | Deposit date: | 2014-08-15 | Release date: | 2015-08-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.818 Å) | Cite: | The Crystal Structures of Middle East Respiratory Syndrome Coronavirus Papain-like Protease and Its Complex with an Inhibitor To be Published
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3HY4
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![BU of 3hy4 by Molmil](/molmil-images/mine/3hy4) | Structure of human MTHFS with N5-iminium phosphate | Descriptor: | 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, N-({trans-4-[({(2R,4R,4aS,6S,8aS)-2-amino-4-hydroxy-5-[(phosphonooxy)methyl]decahydropteridin-6-yl}methyl)amino]cyclohexyl}carbonyl)-L-glutamic acid, ... | Authors: | Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J. | Deposit date: | 2009-06-22 | Release date: | 2009-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.795 Å) | Cite: | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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3HY6
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![BU of 3hy6 by Molmil](/molmil-images/mine/3hy6) | Structure of human MTHFS with ADP | Descriptor: | 5-formyltetrahydrofolate cyclo-ligase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J. | Deposit date: | 2009-06-22 | Release date: | 2009-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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3HXT
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![BU of 3hxt by Molmil](/molmil-images/mine/3hxt) | Structure of human MTHFS | Descriptor: | 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, NICKEL (II) ION | Authors: | Wu, D, Li, Y, Song, G, Cheng, C, Zhang, R, Joachimiak, A, Shaw, N, Liu, Z.-J. | Deposit date: | 2009-06-22 | Release date: | 2009-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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3HY3
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![BU of 3hy3 by Molmil](/molmil-images/mine/3hy3) | Structure of human MTHFS with 10-formyltetrahydrofolate | Descriptor: | 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, N-({4-[{[(2R,4S,4aR,6S,8aS)-2-amino-4-hydroxydecahydropteridin-6-yl]methyl}(formyl)amino]phenyl}carbonyl)-D-glutamic acid, ... | Authors: | Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J. | Deposit date: | 2009-06-22 | Release date: | 2009-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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4PZA
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![BU of 4pza by Molmil](/molmil-images/mine/4pza) | The complex structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c with inorganic phosphate | Descriptor: | Glucosyl-3-phosphoglycerate phosphatase, PHOSPHATE ION | Authors: | Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z. | Deposit date: | 2014-03-29 | Release date: | 2014-06-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.776 Å) | Cite: | Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase J.Biol.Chem., 289, 2014
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4PZ9
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![BU of 4pz9 by Molmil](/molmil-images/mine/4pz9) | The native structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c | Descriptor: | Glucosyl-3-phosphoglycerate phosphatase | Authors: | Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z. | Deposit date: | 2014-03-28 | Release date: | 2014-06-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase J.Biol.Chem., 289, 2014
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4QGU
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![BU of 4qgu by Molmil](/molmil-images/mine/4qgu) | protein domain complex with ssDNA | Descriptor: | DNA (5'-D(P*AP*GP*GP*CP*CP*GP*GP*CP*GP*TP*GP*A)-3'), Gamma-interferon-inducible protein 16 | Authors: | Ni, X, Ru, H, Zhao, L, Shaw, N, Ding, W, Songying, O, Liu, Z.-J. | Deposit date: | 2014-05-25 | Release date: | 2015-06-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.545 Å) | Cite: | New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16. J Mol Cell Biol, 8, 2016
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4QIH
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![BU of 4qih by Molmil](/molmil-images/mine/4qih) | The structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c complexes with VO3 | Descriptor: | Glucosyl-3-phosphoglycerate phosphatase, VANADATE ION | Authors: | Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z. | Deposit date: | 2014-05-30 | Release date: | 2014-06-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase J.Biol.Chem., 289, 2014
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4RVS
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![BU of 4rvs by Molmil](/molmil-images/mine/4rvs) | The native structure of mycobacterial quinone oxidoreductase Rv154c. | Descriptor: | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | Authors: | Zhou, W.H, Zheng, Q.Q, Song, Y.L, Zhang, W, Shaw, N, Rao, Z. | Deposit date: | 2014-11-27 | Release date: | 2015-06-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8464 Å) | Cite: | Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by the co-factor. Febs J., 282, 2015
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4RVU
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![BU of 4rvu by Molmil](/molmil-images/mine/4rvu) | The native structure of mycobacterial Rv1454c complexed with NADPH | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | Authors: | Zhou, W.H, Zheng, Q.Q, Song, Y.L, Zhang, W, Shaw, N, Rao, Z. | Deposit date: | 2014-11-27 | Release date: | 2015-06-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7988 Å) | Cite: | Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by the co-factor. Febs J., 282, 2015
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