3HY4

Structure of human MTHFS with N5-iminium phosphate

Summary for 3HY4

Entry DOI	10.2210/pdb3hy4/pdb
Related	3HXT 3HY3 3HY6
Descriptor	5-formyltetrahydrofolate cyclo-ligase, NICKEL (II) ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	antifolate, cancer, n5-iminium phosphate, acetylation, atp-binding, cytoplasm, folate-binding, ligase, magnesium, nucleotide-binding, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P49914
Total number of polymer chains	1
Total formula weight	24083.80
Authors	Wu, D.,Li, Y.,Song, G.,Cheng, C.,Shaw, N.,Liu, Z.-J. (deposition date: 2009-06-22, release date: 2009-07-14, Last modification date: 2023-11-01)
Primary citation	Wu, D.,Li, Y.,Song, G.,Cheng, C.,Zhang, R.,Joachimiak, A.,Shaw, N.,Liu, Z.-J. Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69:7294-7301, 2009 Cited by PubMed: 19738041 DOI: 10.1158/0008-5472.CAN-09-1927 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.795 Å)

Structure validation