3HY4
Structure of human MTHFS with N5-iminium phosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-formyltetrahydrofolate cyclo-ligase | polymer | 203 | 23289.7 | 1 | UniProt (P49914) Pfam (PF01812) | Homo sapiens (human) | 5,10-methenyl-tetrahydrofolate synthetase, Methenyl-THF synthetase, MTHFS |
| 2 | B (A) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 3 | C, D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | F (A) | N-({trans-4-[({(2R,4R,4aS,6S,8aS)-2-amino-4-hydroxy-5-[(phosphonooxy)methyl]decahydropteridin-6-yl}methyl)amino]cyclohexyl}carbonyl)-L-glutamic acid | non-polymer | 567.5 | 1 | Chemie (N5G) | |||
| 5 | G (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | H (A) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23289.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 794.1 | |
| All* | Total formula weight | 24083.8 |
