3HY4
Structure of human MTHFS with N5-iminium phosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005542 | molecular_function | folic acid binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006536 | biological_process | glutamate metabolic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0015942 | biological_process | formate metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0030272 | molecular_function | 5-formyltetrahydrofolate cyclo-ligase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0046657 | biological_process | folic acid catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 204 |
| Chain | Residue |
| A | ARG82 |
| A | HIS89 |
| A | ASP91 |
| A | HIS163 |
| A | HOH250 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 205 |
| Chain | Residue |
| A | GLU27 |
| A | HIS142 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 206 |
| Chain | Residue |
| A | LEU181 |
| A | HOH233 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 207 |
| Chain | Residue |
| A | MET92 |
| A | ALA123 |
| A | LEU124 |
| A | TYR156 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE N5G A 501 |
| Chain | Residue |
| A | PHE55 |
| A | LEU56 |
| A | GLU61 |
| A | TYR83 |
| A | MET90 |
| A | TRP109 |
| A | PRO135 |
| A | ARG148 |
| A | GLY149 |
| A | LYS150 |
| A | LYS150 |
| A | TYR152 |
| A | TYR153 |
| A | HOH217 |
| A | HOH230 |
| A | HOH251 |
| A | PO4502 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 502 |
| Chain | Residue |
| A | ARG145 |
| A | GLY147 |
| A | ARG148 |
| A | GLY149 |
| A | LYS150 |
| A | GLY151 |
| A | TYR152 |
| A | TYR153 |
| A | ASP154 |
| A | N5G501 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS10 | |
| A | ARG14 | |
| A | LEU56 | |
| A | GLU61 | |
| A | ARG145 | |
| A | ARG148 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP154 | |
| A | ASP189 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 |
