1UM4
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![BU of 1um4 by Molmil](/molmil-images/mine/1um4) | Catalytic Antibody 21H3 with hapten | Descriptor: | (1R)-1-PHENYLETHYL 4-(ACETYLAMINO)BENZYLPHOSPHONATE, Antibody 21H3 H chain, Antibody 21H3 L chain | Authors: | Beuscher IV, A.E, Reuter, J, Olson, A.J, Romesberg, F.E, Schultz, P.G, Wirsching, P, Janda, K.D, Lerner, R.A, Stevens, R.C. | Deposit date: | 2003-09-23 | Release date: | 2004-10-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Studies of an Efficient Catalytic Antibody Operating by Ping-Pong and Induced Fit Mechanisms To be Published
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1FL6
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![BU of 1fl6 by Molmil](/molmil-images/mine/1fl6) | THE HAPTEN COMPLEXED GERMLINE PRECURSOR TO SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4 | Descriptor: | 1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID, ANTIBODY GERMLINE PRECURSOR TO 28B4 | Authors: | Yin, J, Mundorff, E.C, Yang, P.L, Wendt, K.U, Hanway, D, Stevens, R.C, Schultz, P.G. | Deposit date: | 2000-08-11 | Release date: | 2001-11-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A comparative analysis of the immunological evolution of antibody 28B4. Biochemistry, 40, 2001
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1FL5
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![BU of 1fl5 by Molmil](/molmil-images/mine/1fl5) | THE UNLIGANDED GERMLINE PRECURSOR TO THE SULFIDE OXIDASE CATALYTIC ANTIBODY 28B4. | Descriptor: | ANTIBODY GERMLINE PRECURSOR TO ANTIBODY 28B4, SULFATE ION | Authors: | Yin, J, Mundorff, E.C, Yang, P.L, Wendt, K.U, Hanway, D, Stevens, R.C, Schultz, P.G. | Deposit date: | 2000-08-11 | Release date: | 2001-11-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A comparative analysis of the immunological evolution of antibody 28B4. Biochemistry, 40, 2001
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3HWL
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![BU of 3hwl by Molmil](/molmil-images/mine/3hwl) | Crystal Structure of T4 lysozyme with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 131 | Descriptor: | AZIDE ION, CHLORIDE ION, Lysozyme | Authors: | Fleissner, M.R, Cascio, D, Schultz, P.G, Hubbell, W.L. | Deposit date: | 2009-06-17 | Release date: | 2009-12-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Site-directed spin labeling of a genetically encoded unnatural amino acid. Proc.Natl.Acad.Sci.USA, 106, 2009
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2PIS
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![BU of 2pis by Molmil](/molmil-images/mine/2pis) | Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs | Descriptor: | DNA (5'-D(*CP*GP*(CBR)P*GP*AP*AP*(FFD)P*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION | Authors: | Matsuda, S, Fillo, J.D, Henry, A.A, Wilkins, S.J, Rai, P, Dwyer, T.J, Geierstanger, B.H, Wemmer, D.E, Schultz, P.G, Spraggon, G, Romesberg, F.E. | Deposit date: | 2007-04-13 | Release date: | 2007-10-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs. J.Am.Chem.Soc., 129, 2007
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1UM6
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![BU of 1um6 by Molmil](/molmil-images/mine/1um6) | catalytic antibody 21h3 | Descriptor: | antibody 21h3, H chain, L chain | Authors: | Beuscher IV, A.E, Reuter, J, Olson, A.J, Romesberg, F.E, Schultz, P.G, Wirsching, P, Janda, K.D, Lerner, R.A, Stevens, R.C. | Deposit date: | 2003-09-23 | Release date: | 2004-10-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Studies of an Efficient Catalytic Antibody Operating by Ping-Pong and Induced Fit Mechanisms To be Published
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1UM5
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![BU of 1um5 by Molmil](/molmil-images/mine/1um5) | Catalytic Antibody 21H3 with alcohol substrate | Descriptor: | 1-PHENYLETHANOL, Antibody 21H3 H chain, Antibody 21H3 L chain | Authors: | Beuscher IV, A.E, Reuter, J, Olson, A.J, Romesberg, F.E, Schultz, P.G, Wirsching, P, Janda, K.D, Lerner, R.A, Stevens, R.C. | Deposit date: | 2003-09-23 | Release date: | 2004-10-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Studies of an Efficient Catalytic Antibody Operating by Ping-Pong and Induced Fit Mechanisms To be Published
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1JES
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![BU of 1jes by Molmil](/molmil-images/mine/1jes) | Crystal Structure of a Copper-Mediated Base Pair in DNA | Descriptor: | 5'-D(*CP*GP*CP*GP*(DPY)P*AP*TP*(DRP)P*CP*GP*CP*G)-3', COPPER (II) ION | Authors: | Atwell, S, Meggers, E, Spraggon, G, Schultz, P.G. | Deposit date: | 2001-06-18 | Release date: | 2001-11-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of a Copper-Mediated Base Pair in DNA J.Am.Chem.Soc., 123, 2001
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1HKL
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![BU of 1hkl by Molmil](/molmil-images/mine/1hkl) | FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY | Descriptor: | 48G7 FAB | Authors: | Wedemayer, G.J, Wang, L.H, Patten, P.A, Schultz, P.G, Stevens, R.C. | Deposit date: | 1996-12-20 | Release date: | 1997-03-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Crystal structures of the free and liganded form of an esterolytic catalytic antibody. J.Mol.Biol., 268, 1997
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5OEJ
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![BU of 5oej by Molmil](/molmil-images/mine/5oej) | Structure of Tra1 subunit within the chromatin modifying complex SAGA | Descriptor: | Tra1 subunit within the chromatin modifying complex SAGA | Authors: | Sharov, G, Voltz, K, Durand, A, Kolesnikova, O, Papai, G, Myasnikov, A.G, Dejaegere, A, Ben-Shem, A, Schultz, P. | Deposit date: | 2017-07-07 | Release date: | 2017-08-02 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA. Nat Commun, 8, 2017
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3RIX
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![BU of 3rix by Molmil](/molmil-images/mine/3rix) | 1.7A resolution structure of a firefly luciferase-Aspulvinone J inhibitor complex | Descriptor: | (5Z)-4-hydroxy-3-[(2R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-yl]-5-{[(2R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-yl]methylidene}furan-2(5H)-one, Luciferin 4-monooxygenase | Authors: | Lovell, S, Battaile, K.P, Lopez, P.C, Auld, D.S, Schultz, P.J, MacArthur, R, Shen, M, Tamayo, G, Inglese, J, Sherman, D.H. | Deposit date: | 2011-04-14 | Release date: | 2011-12-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors. Chem.Biol., 18, 2011
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6HQA
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![BU of 6hqa by Molmil](/molmil-images/mine/6hqa) | Molecular structure of promoter-bound yeast TFIID | Descriptor: | Histone-fold, Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation, ... | Authors: | Kolesnikova, O, Ben-Shem, A, Luo, J, Ranish, J, Schultz, P, Papai, G. | Deposit date: | 2018-09-24 | Release date: | 2018-11-21 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Molecular structure of promoter-bound yeast TFIID. Nat Commun, 9, 2018
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3D6V
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![BU of 3d6v by Molmil](/molmil-images/mine/3d6v) | Crystal structure of 4-(trifluoromethyldiazirinyl)phenylalanyl-tRNA synthetase | Descriptor: | 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE, BETA-MERCAPTOETHANOL, Tyrosyl-tRNA synthetase | Authors: | Liu, W, Tippmann, E, Mack, A.V, Schultz, P.G. | Deposit date: | 2008-05-20 | Release date: | 2008-05-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A genetically encoded diazirine photocrosslinker in Escherichia coli ChemBioChem, 8, 2007
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6TBM
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![BU of 6tbm by Molmil](/molmil-images/mine/6tbm) | Structure of SAGA bound to TBP, including Spt8 and DUB | Descriptor: | Polyubiquitin-B, SAGA-associated factor 11, Spt20, ... | Authors: | Papai, G, Frechard, A, Kolesnikova, O, Crucifix, C, Schultz, P, Ben-Shem, A. | Deposit date: | 2019-11-01 | Release date: | 2020-02-12 | Last modified: | 2021-06-30 | Method: | ELECTRON MICROSCOPY (20 Å) | Cite: | Structure of SAGA and mechanism of TBP deposition on gene promoters. Nature, 577, 2020
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3D6U
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![BU of 3d6u by Molmil](/molmil-images/mine/3d6u) | Crystal structure of 4-(trifluoromethyldiazirinyl)phenylalanyl-tRNA synthetase | Descriptor: | 4-[3-(TRIFLUOROMETHYL)DIAZIRIDIN-3-YL]-L-PHENYLALANINE, BETA-MERCAPTOETHANOL, Tyrosyl-tRNA synthetase | Authors: | Liu, W, Tippmann, E, Mack, A.V, Schultz, P.G. | Deposit date: | 2008-05-20 | Release date: | 2008-05-27 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A genetically encoded diazirine photocrosslinker in Escherichia coli ChemBioChem, 8, 2007
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1GAF
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![BU of 1gaf by Molmil](/molmil-images/mine/1gaf) | 48G7 HYBRIDOMA LINE FAB COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID | Descriptor: | 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID, CHIMERIC 48G7 FAB | Authors: | Wedemayer, G.J, Patten, P.A, Stevens, R.C, Schultz, P.G. | Deposit date: | 1996-02-06 | Release date: | 1996-07-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The immunological evolution of catalysis. Science, 271, 1996
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3FCT
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![BU of 3fct by Molmil](/molmil-images/mine/3fct) | MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN | Descriptor: | CADMIUM ION, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Romesberg, F.E, Santarsiero, B.D, Barnes, D, Yin, J, Spiller, B, Schultz, P.G, Stevens, R.C. | Deposit date: | 1999-06-13 | Release date: | 1999-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and kinetic evidence for strain in biological catalysis. Biochemistry, 37, 1998
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2HGZ
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![BU of 2hgz by Molmil](/molmil-images/mine/2hgz) | Crystal structure of a p-benzoyl-L-phenylalanyl-tRNA synthetase | Descriptor: | PARA-(BENZOYL)-PHENYLALANINE, Tyrosyl-tRNA synthetase | Authors: | Liu, W, Alfonta, L, Mack, A.V, Schultz, P.G. | Deposit date: | 2006-06-27 | Release date: | 2007-06-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases. Angew.Chem.Int.Ed.Engl., 46, 2007
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1AJ7
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![BU of 1aj7 by Molmil](/molmil-images/mine/1aj7) | IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY | Descriptor: | 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID, IMMUNOGLOBULIN 48G7 FAB (HEAVY CHAIN), IMMUNOGLOBULIN 48G7 FAB (LIGHT CHAIN) | Authors: | Wedemayer, G.J, Wang, L.H, Patten, P.A, Schultz, P.G, Stevens, R.C. | Deposit date: | 1997-05-15 | Release date: | 1997-11-12 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the evolution of an antibody combining site. Science, 276, 1997
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4ZJ1
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![BU of 4zj1 by Molmil](/molmil-images/mine/4zj1) | Crystal Structure of p-acrylamido-phenylalanine modified TEM1 beta-lactamase from Escherichia coli : V216AcrF mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase TEM, DI(HYDROXYETHYL)ETHER, ... | Authors: | Xiao, H, Nasertorabi, F, Choi, S, Han, G.W, Reed, S.A, Stevens, R.C, Schultz, P.G. | Deposit date: | 2015-04-28 | Release date: | 2015-05-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Exploring the potential impact of an expanded genetic code on protein function. Proc.Natl.Acad.Sci.USA, 112, 2015
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1U7D
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![BU of 1u7d by Molmil](/molmil-images/mine/1u7d) | |
4ZJ2
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![BU of 4zj2 by Molmil](/molmil-images/mine/4zj2) | Crystal Structure of p-acrylamido-phenylalanine modified TEM1 beta-lactamase from Escherichia coli :E166N mutant | Descriptor: | Beta-lactamase TEM | Authors: | Xiao, H, Nasertorabi, F, Choi, S, Han, G.W, Reed, S.A, Stevens, C.S, Schultz, P.G. | Deposit date: | 2015-04-28 | Release date: | 2015-05-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Exploring the potential impact of an expanded genetic code on protein function. Proc.Natl.Acad.Sci.USA, 112, 2015
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1U7X
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![BU of 1u7x by Molmil](/molmil-images/mine/1u7x) | crystal structure of a mutant M. jannashii tyrosyl-tRNA synthetase specific for O-methyl-tyrosine | Descriptor: | POTASSIUM ION, Tyrosyl-tRNA synthetase | Authors: | Zhang, Y, Wang, L, Schultz, P.G, Wilson, I.A. | Deposit date: | 2004-08-04 | Release date: | 2005-05-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine. Protein Sci., 14, 2005
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2AG6
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![BU of 2ag6 by Molmil](/molmil-images/mine/2ag6) | Crystal structure of p-bromo-l-phenylalanine-tRNA sythetase in complex with p-bromo-l-phenylalanine | Descriptor: | 4-BROMO-L-PHENYLALANINE, Tyrosyl-tRNA synthetase | Authors: | Turner, J.M, Graziano, J, Spraggon, G, Schultz, P.G. | Deposit date: | 2005-07-26 | Release date: | 2006-04-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural plasticity of an aminoacyl-tRNA synthetase active site Proc.Natl.Acad.Sci.Usa, 103, 2006
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1PVQ
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![BU of 1pvq by Molmil](/molmil-images/mine/1pvq) | BASIS FOR A SWITCH IN SUBSTRATE SPECIFICITY: CRYSTAL STRUCTURE OF SELECTED VARIANT OF CRE SITE-SPECIFIC RECOMBINASE, LNSGG BOUND TO THE ENGINEERED RECOGNITION SITE LOXM7 | Descriptor: | DNA 34-MER, Recombinase cre | Authors: | Baldwin, E.P, Martin, S.S, Abel, J, Gelato, K.A, Kim, H, Schultz, P.G, Santoro, S.W. | Deposit date: | 2003-06-28 | Release date: | 2004-02-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | A specificity switch in selected cre recombinase variants is mediated by macromolecular plasticity and water. Chem.Biol., 10, 2003
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