4F91
 
 | | Brr2 Helicase Region | | 分子名称: | U5 small nuclear ribonucleoprotein 200 kDa helicase | | 著者 | Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C. | | 登録日 | 2012-05-18 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.697 Å) | | 主引用文献 | Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4F93
 | | Brr2 Helicase Region S1087L, Mg-ATP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C. | | 登録日 | 2012-05-18 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4F92
 | | Brr2 Helicase Region S1087L | | 分子名称: | SULFANILAMIDE, U5 small nuclear ribonucleoprotein 200 kDa helicase | | 著者 | Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C. | | 登録日 | 2012-05-18 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.662 Å) | | 主引用文献 | Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6S8Q
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4ILJ
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4ILI
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4ILG
 | | Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | | 著者 | Weber, G, Heroven, A.C, Santos, K.F, Wahl, M.C. | | 登録日 | 2012-12-31 | | 公開日 | 2013-03-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for dual roles of Aar2p in U5 snRNP assembly.
Genes Dev., 27, 2013
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4ILH
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4RVQ
 | | PWI-like domain of Chaetomium thermophilum Brr2 | | 分子名称: | 1,2-ETHANEDIOL, Pre-mRNA splicing helicase-like protein, SULFATE ION | | 著者 | Absmeier, E, Rosenberger, L, Santos, K.F, Becke, C, Wahl, M.C. | | 登録日 | 2014-11-27 | | 公開日 | 2015-04-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.135 Å) | | 主引用文献 | A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein.
Acta Crystallogr.,Sect.D, 71, 2015
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5M52
 | | Crystal structure of yeast Brr2 full-lenght in complex with Prp8 Jab1 domain | | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | | 著者 | Wollenhaupt, J, Absmeier, E, Becke, C, Santos, K.F, Wahl, M.C. | | 登録日 | 2016-10-20 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.
Cell Cycle, 16, 2017
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5M5P
 | | S. cerevisiae spliceosomal helicase Brr2 (271-end) in complex with the Jab/MPN domain of S. cerevisiae Prp8 | | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | | 著者 | Becke, C, Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | | 登録日 | 2016-10-22 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.
Cell Cycle, 16, 2017
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5M59
 | | Crystal structure of Chaetomium thermophilum Brr2 helicase core in complex with Prp8 Jab1 domain | | 分子名称: | ACETATE ION, Pre-mRNA splicing helicase-like protein, Putative pre-mRNA splicing factor | | 著者 | Absmeier, E, Becke, C, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | | 登録日 | 2016-10-20 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.
Cell Cycle, 16, 2017
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7BDK
 | | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ... | | 著者 | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | | 登録日 | 2020-12-21 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
J.Biol.Chem., 297, 2021
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7BDL
 | | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ADP | | 分子名称: | MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | | 著者 | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | | 登録日 | 2020-12-21 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
J.Biol.Chem., 297, 2021
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7BDJ
 | | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS | | 分子名称: | MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | | 著者 | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | | 登録日 | 2020-12-21 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
J.Biol.Chem., 297, 2021
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7BDI
 | | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ATPgammaS | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Pre-mRNA-processing-splicing factor 8, ... | | 著者 | Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. | | 登録日 | 2020-12-21 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.
J.Biol.Chem., 297, 2021
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9C0Z
 | | Clathrin terminal domain complexed with pitstop 2d | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | | 著者 | Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. | | 登録日 | 2024-05-28 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function
To Be Published
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9C0Y
 | | Clathrin terminal domain complexed with Pitstop 2c | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ... | | 著者 | Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. | | 登録日 | 2024-05-28 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function
To Be Published
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5DCA
 | | Crystal structure of yeast full length Brr2 in complex with Prp8 Jab1 domain | | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | | 著者 | Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | | 登録日 | 2015-08-23 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.
Genes Dev., 29, 2015
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6QV3
 | | Crystal structure of the Ski2 RNA-helicase Brr2 from Chaetomium thermophilum bound to ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | | 著者 | Absmeier, E, Santos, K.F, Wahl, M.C. | | 登録日 | 2019-03-01 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase.
Structure, 28, 2020
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6QWS
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6S9I
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6QV4
 | | Crystal structure of the Ski2 RNA-helicase Brr2 from Chaetomium thermophilum bound to ATP-gamma-S | | 分子名称: | ACETATE ION, MANGANESE (II) ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Absmeier, E, Santos, K.F, Wahl, M.C. | | 登録日 | 2019-03-01 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase.
Structure, 28, 2020
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6S8O
 | | Human Brr2 Helicase Region M641C/A1582C | | 分子名称: | U5 small nuclear ribonucleoprotein 200 kDa helicase | | 著者 | Vester, K, Santos, K.F, Wahl, M.C. | | 登録日 | 2019-07-10 | | 公開日 | 2020-01-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.172 Å) | | 主引用文献 | The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit.
J.Biol.Chem., 295, 2020
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3SBS
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