7BDJ

Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS

Summary for 7BDJ

• Entry DOI: 10.2210/pdb7bdj/pdb
• Related: 7BDI 7BDK 7BDL
• Descriptor: U5 small nuclear ribonucleoprotein 200 kDa helicase, Pre-mRNA-processing-splicing factor 8, [[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-[2-(methylamino)phenyl]carbonyloxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphinic acid, ... (5 entities in total)
• Functional Keywords: rnp remodeling, pre-mrna splicing, spliceosome catalytic activation, dexd/h-box rna helicase, rna and atp binding, nucleus, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 231161.28

Authors

Vester, K.,Santos, K.F.,Absmeier, E.,Wahl, M.C. (deposition date: 2020-12-21, release date: 2021-06-09, Last modification date: 2024-01-31)

• Primary citation: Absmeier, E.,Vester, K.,Ghane, T.,Burakovskiy, D.,Milon, P.,Imhof, P.,Rodnina, M.V.,Santos, K.F.,Wahl, M.C.; Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2.; J.Biol.Chem., 297:100829-100829, 2021; PubMed: 34048711; DOI: 10.1016/j.jbc.2021.100829

Experimental method

X-RAY DIFFRACTION (2.59 Å)