6S8O

Human Brr2 Helicase Region M641C/A1582C

Summary for 6S8O

Entry DOI	10.2210/pdb6s8o/pdb
Descriptor	U5 small nuclear ribonucleoprotein 200 kDa helicase (2 entities in total)
Functional Keywords	rnp remodeling, pre-mrna splicing, spliceosome catalytic activation, dexd/h-box rna helicase, rna and atp binding, nucleus, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	199670.67
Authors	Vester, K.,Santos, K.F.,Wahl, M.C. (deposition date: 2019-07-10, release date: 2020-01-22, Last modification date: 2024-01-24)
Primary citation	Vester, K.,Santos, K.F.,Kuropka, B.,Weise, C.,Wahl, M.C. The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295:2097-2112, 2020 Cited by PubMed: 31914407 DOI: 10.1074/jbc.RA119.010964 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.172 Å)

Structure validation