6S8Q

Human Brr2 Helicase Region in complex with C-tail deleted Jab1

Summary for 6S8Q

• Entry DOI: 10.2210/pdb6s8q/pdb
• Descriptor: U5 small nuclear ribonucleoprotein 200 kDa helicase, Pre-mRNA-processing-splicing factor 8, SULFATE ION, ... (4 entities in total)
• Functional Keywords: rnp remodeling, pre-mrna splicing, spliceosome catalytic activation, dexd/h-box rna helicase, rna and atp binding, nucleus, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 229992.01

Authors

Santos, K.F.,Vester, K.,Wahl, M.C. (deposition date: 2019-07-10, release date: 2020-01-22, Last modification date: 2020-02-26)

• Primary citation: Vester, K.,Santos, K.F.,Kuropka, B.,Weise, C.,Wahl, M.C.; The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit.; J.Biol.Chem., 295:2097-2112, 2020; PubMed: 31914407; DOI: 10.1074/jbc.RA119.010964

Experimental method

X-RAY DIFFRACTION (2.391 Å)