7OKX
| Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1 (composite structure) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | 登録日 | 2021-05-18 | 公開日 | 2021-07-14 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Allosteric transcription stimulation by RNA polymerase II super elongation complex. Mol.Cell, 81, 2021
|
|
7OL0
| Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | 登録日 | 2021-05-18 | 公開日 | 2021-07-14 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Allosteric transcription stimulation by RNA polymerase II super elongation complex. Mol.Cell, 81, 2021
|
|
7OKY
| Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | 登録日 | 2021-05-18 | 公開日 | 2021-07-14 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Allosteric transcription stimulation by RNA polymerase II super elongation complex. Mol.Cell, 81, 2021
|
|
5KUX
| |
7OM8
| |
7OWG
| human DEPTOR in a complex with mutant human mTORC1 A1459P | 分子名称: | DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... | 著者 | Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
|
|
5KUY
| |
5KVJ
| |
7OXR
| |
7OXP
| Cryo-EM structure of yeast Sei1 | 分子名称: | BJ4_G0032880.mRNA.1.CDS.1,BJ4_G0032880.mRNA.1.CDS.1 | 著者 | Deme, J.C, Lea, S.M. | 登録日 | 2021-06-22 | 公開日 | 2021-10-13 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex. Nat Commun, 12, 2021
|
|
7P9V
| Cryo EM structure of System XC- | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | 登録日 | 2021-07-28 | 公開日 | 2021-11-17 | 最終更新日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis for redox control by the human cystine/glutamate antiporter system xc . Nat Commun, 12, 2021
|
|
7P9U
| Cryo EM structure of System XC- in complex with glutamate | 分子名称: | 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter, GLUTAMIC ACID | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | 登録日 | 2021-07-28 | 公開日 | 2021-11-17 | 最終更新日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis for redox control by the human cystine/glutamate antiporter system xc . Nat Commun, 12, 2021
|
|
5L3X
| |
7OTI
| Structure of ABCB1/P-glycoprotein in apo state | 分子名称: | Multidrug resistance protein 1A | 著者 | Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F. | 登録日 | 2021-06-10 | 公開日 | 2021-12-08 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11, 2021
|
|
7OTG
| Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor | 分子名称: | Multidrug resistance protein 1A, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide | 著者 | Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F. | 登録日 | 2021-06-10 | 公開日 | 2021-12-08 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11, 2021
|
|
5LHX
| |
5LHY
| PB3 Domain of Human PLK4 (apo) | 分子名称: | Serine/threonine-protein kinase PLK4 | 著者 | Cottee, M.A, Johnson, S, Lea, S.M. | 登録日 | 2016-07-13 | 公開日 | 2017-03-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | 主引用文献 | A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies. Biol Open, 6, 2017
|
|
5LJ3
| Structure of the core of the yeast spliceosome immediately after branching | 分子名称: | CEF1, CLF1, CWC15, ... | 著者 | Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K. | 登録日 | 2016-07-17 | 公開日 | 2016-08-03 | 最終更新日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the spliceosome immediately after branching. Nature, 537, 2016
|
|
7ONF
| The binding of p-coumaroyl glucose to glycogen phosphorylase reveals the relationship between structural data and effects on cell metabolome | 分子名称: | Glycogen phosphorylase, muscle form, INOSINIC ACID, ... | 著者 | Tsagkarakou, A.S, Koulas, S.M, Kyriakis, E, Drakou, C.E, Leonidas, D.D. | 登録日 | 2021-05-25 | 公開日 | 2022-04-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways Eur J Med Chem Rep, 3, 2021
|
|
7P1C
| Crystal structure of E.coli BamA beta-barrel in complex with darobactin B | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Outer membrane protein assembly factor BamA, TRP-ASN-UX8-THR-LYS-ARG-PHE | 著者 | Jakob, R.P, Modaresi, S.M, Hiller, S, Maier, T. | 登録日 | 2021-07-01 | 公開日 | 2022-04-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mutasynthetic Production and Antimicrobial Characterization of Darobactin Analogs. Microbiol Spectr, 9, 2021
|
|
5LRC
| Crystal structure of Glycogen Phosphorylase in complex with KS114 | 分子名称: | (1S)-1,5-anhydro-1-(5-phenyl-4H-1,2,4-triazol-3-yl)-D-glucitol, Glycogen phosphorylase, muscle form, ... | 著者 | Kantsadi, A.L, Stravodimos, G.A, Chatzileontiadou, D.S.M, Leonidas, D.D. | 登録日 | 2016-08-18 | 公開日 | 2017-06-14 | 最終更新日 | 2020-08-05 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | van der Waals interactions govern C-beta-d-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase. J. Struct. Biol., 199, 2017
|
|
5LHZ
| |
7OKR
| Catalytic domain from the Aliivibrio salmonicida lytic polysaccharide monooxygenase AsLPMO10B | 分子名称: | COPPER (II) ION, Chitinase B, DI(HYDROXYETHYL)ETHER | 著者 | Cordara, G, Leitl, K.D, Loose, J.S.M, Vaaje-Kolstad, G, Krengel, U. | 登録日 | 2021-05-18 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Chitinolytic enzymes contribute to the pathogenicity of Aliivibrio salmonicida LFI1238 in the invasive phase of cold-water vibriosis. Bmc Microbiol., 22, 2022
|
|
7P0I
| Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor Compound 13 | 分子名称: | (1S,20E)-10-(benzofuran-3-ylmethyl)-12-methyl-15,18-dioxa-5,9,12,24,26-pentazapentacyclo[20.5.2.11,4.13,7.025,28]hentriaconta-3(30),4,6,20,22(29),23,25(28)-heptaene-8,11,27-trione, Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, TETRAETHYLENE GLYCOL, ... | 著者 | Southall, S.M. | 登録日 | 2021-06-29 | 公開日 | 2022-06-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes. Acs Chem Neurosci, 13, 2022
|
|
7P0F
| Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor HTL0028125 | 分子名称: | (1S,10R,23E)-12-methyl-10-[(7-methyl-1H-indazol-5-yl)methyl]-15,18,21-trioxa-5,9,12,27,29-pentazapentacyclo[23.5.2.11,4.13,7.028,31]tetratriaconta-3(33),4,6,23,25(32),26,28(31)-heptaene-8,11,30-trione, Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, TETRAETHYLENE GLYCOL, ... | 著者 | Southall, S.M, Watson, S.P. | 登録日 | 2021-06-29 | 公開日 | 2022-06-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes. Acs Chem Neurosci, 13, 2022
|
|