2J24
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![BU of 2j24 by Molmil](/molmil-images/mine/2j24) | The functional role of the conserved active site proline of triosephosphate isomerase | Descriptor: | TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL | Authors: | Casteleijn, M.G, Alahuhta, M, Groebel, K, El-Sayed, I, Augustyns, K, Lambeir, A.M, Neubauer, P, Wierenga, R.K. | Deposit date: | 2006-08-16 | Release date: | 2007-01-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional Role of the Conserved Active Site Proline of Triosephosphate Isomerase. Biochemistry, 45, 2006
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1AFW
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1NAE
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![BU of 1nae by Molmil](/molmil-images/mine/1nae) | Structure of CsCBM6-3 from Clostridium stercorarium in complex with xylotriose | Descriptor: | CALCIUM ION, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, putative xylanase | Authors: | Boraston, A.B, Notenboom, V, Warren, R.A.J, Kilburn, D.G, Rose, D.R, Davies, G. | Deposit date: | 2002-11-27 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure and ligand binding of carbohydrate-binding module CsCBM6-3 reveals similarities with fucose-specific lectins and "galactose-binding" domains J.Mol.Biol., 327, 2003
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2JF4
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![BU of 2jf4 by Molmil](/molmil-images/mine/2jf4) | Family 37 trehalase from Escherichia coli in complex with validoxylamine | Descriptor: | (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, PERIPLASMIC TREHALASE | Authors: | Gibson, R.P, Gloster, T.M, Roberts, S, Warren, R.A.J, Storch De Gracia, I, Garcia, A, Chiara, J.L, Davies, G.J. | Deposit date: | 2007-01-25 | Release date: | 2007-02-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors. Angew.Chem.Int.Ed.Engl., 46, 2007
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2RNF
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![BU of 2rnf by Molmil](/molmil-images/mine/2rnf) | X-RAY CRYSTAL STRUCTURE OF HUMAN RIBONUCLEASE 4 IN COMPLEX WITH D(UP) | Descriptor: | 2'-DEOXYURIDINE 3'-MONOPHOSPHATE, RIBONUCLEASE 4 | Authors: | Terzyan, S.S, Peracaula, R, De Llorens, R, Tsushima, Y, Yamada, H, Seno, M, Gomis-Ruth, F.X, Coll, M. | Deposit date: | 1998-11-03 | Release date: | 1999-11-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. J.Mol.Biol., 285, 1999
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2VCY
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![BU of 2vcy by Molmil](/molmil-images/mine/2vcy) | Crystal Structure of 2-Enoyl Thioester Reductase of Human FAS II | Descriptor: | SULFATE ION, TRANS-2-ENOYL-COA REDUCTASE | Authors: | Haapalainen, A.M, Pudas, R, Smart, O.S, Wierenga, R.K. | Deposit date: | 2007-09-28 | Release date: | 2008-06-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural Enzymological Studies of 2-Enoyl Thioester Reductase of the Human Mitochondrial Fas II Pathway: New Insights Into its Substrate Recognition Properties. J.Mol.Biol., 379, 2008
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2JIJ
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![BU of 2jij by Molmil](/molmil-images/mine/2jij) | Crystal structure of the apo form of Chlamydomonas reinhardtii prolyl- 4 hydroxylase type I | Descriptor: | CHLORIDE ION, PROLYL-4 HYDROXYLASE | Authors: | Koski, M.K, Hieta, R, Bollner, C, Kivirikko, K.I, Myllyharju, J, Wierenga, R.K. | Deposit date: | 2007-06-28 | Release date: | 2007-10-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Active Site of an Algal Prolyl 4-Hydroxylase Has a Large Structural Plasticity. J.Biol.Chem., 282, 2007
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1NL7
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1KV5
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![BU of 1kv5 by Molmil](/molmil-images/mine/1kv5) | Structure of Trypanosoma brucei brucei TIM with the salt-bridge-forming residue Arg191 mutated to Ser | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-PHOSPHOGLYCOLIC ACID, GLYCEROL, ... | Authors: | Kursula, I, Partanen, S, Lambeir, A.-M, Wierenga, R.K. | Deposit date: | 2002-01-25 | Release date: | 2002-03-29 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The importance of the conserved Arg191-Asp227 salt bridge of triosephosphate isomerase for folding, stability, and catalysis FEBS Lett., 518, 2002
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1B9B
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![BU of 1b9b by Molmil](/molmil-images/mine/1b9b) | TRIOSEPHOSPHATE ISOMERASE OF THERMOTOGA MARITIMA | Descriptor: | PROTEIN (TRIOSEPHOSPHATE ISOMERASE), SULFATE ION | Authors: | Maes, D, Wierenga, R.K. | Deposit date: | 1999-02-09 | Release date: | 2000-01-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures. Proteins, 37, 1999
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1X74
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![BU of 1x74 by Molmil](/molmil-images/mine/1x74) | Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis- mutational and structural characterization of the fold and active site | Descriptor: | 2-methylacyl-CoA racemase, GLYCEROL, PHOSPHATE ION | Authors: | Kalle, S, Bhaumik, P, Schmitz, W, Kotti, T.J, Conzelmann, E, Wierenga, R.K, Hiltunen, J.K. | Deposit date: | 2004-08-13 | Release date: | 2005-01-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | {alpha}-Methylacyl-CoA Racemase from Mycobacterium tuberculosis: MUTATIONAL AND STRUCTURAL CHARACTERIZATION OF THE ACTIVE SITE AND THE FOLD J.Biol.Chem., 280, 2005
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2PUG
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![BU of 2pug by Molmil](/molmil-images/mine/2pug) | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | Authors: | Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G. | Deposit date: | 1997-10-04 | Release date: | 1998-05-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry, 37, 1998
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2PTK
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![BU of 2ptk by Molmil](/molmil-images/mine/2ptk) | CHICKEN SRC TYROSINE KINASE | Descriptor: | TYROSINE-PROTEIN KINASE TRANSFORMING PROTEIN SRC | Authors: | Williams, J.C, Wierenga, R. | Deposit date: | 1997-06-17 | Release date: | 1997-12-24 | Last modified: | 2018-04-11 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions J.Mol.Biol., 274, 1997
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2PUF
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![BU of 2puf by Molmil](/molmil-images/mine/2puf) | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR) | Authors: | Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G. | Deposit date: | 1997-10-04 | Release date: | 1998-05-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry, 37, 1998
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2GCI
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![BU of 2gci by Molmil](/molmil-images/mine/2gci) | The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an asparte/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety | Descriptor: | (R)-2-METHYLMYRISTOYL-COENZYME A, GLYCEROL, probable alpha-methylacyl-CoA racemase MCR | Authors: | Bhaumik, P, Wierenga, R.K. | Deposit date: | 2006-03-14 | Release date: | 2007-02-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Catalysis of the 1,1-Proton Transfer by alpha-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface J.Mol.Biol., 367, 2007
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2GD2
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![BU of 2gd2 by Molmil](/molmil-images/mine/2gd2) | The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety | Descriptor: | ACETOACETYL-COENZYME A, GLYCEROL, probable alpha-methylacyl-CoA racemase MCR | Authors: | Bhaumik, P, Wierenga, R.K. | Deposit date: | 2006-03-15 | Release date: | 2007-02-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Catalysis of the 1,1-Proton Transfer by alpha-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface J.Mol.Biol., 367, 2007
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2PUD
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![BU of 2pud by Molmil](/molmil-images/mine/2pud) | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | Authors: | Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | Deposit date: | 1997-10-04 | Release date: | 1998-05-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science, 266, 1994
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2PUC
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![BU of 2puc by Molmil](/molmil-images/mine/2puc) | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR) | Authors: | Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | Deposit date: | 1997-10-04 | Release date: | 1998-05-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science, 266, 1994
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1HAB
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![BU of 1hab by Molmil](/molmil-images/mine/1hab) | CROSSLINKED HAEMOGLOBIN | Descriptor: | 4-CARBOXYCINNAMIC ACID, CARBON MONOXIDE, HEMOGLOBIN A, ... | Authors: | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | Deposit date: | 1996-03-13 | Release date: | 1997-11-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Allosteric intermediates indicate R2 is the liganded hemoglobin end state. Proc.Natl.Acad.Sci.USA, 94, 1997
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1OU6
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1HAC
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![BU of 1hac by Molmil](/molmil-images/mine/1hac) | CROSSLINKED HAEMOGLOBIN | Descriptor: | 2,6-DICARBOXYNAPHTHALENE, CARBON MONOXIDE, HEMOGLOBIN A, ... | Authors: | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | Deposit date: | 1996-03-13 | Release date: | 1997-11-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Allosteric intermediates indicate R2 is the liganded hemoglobin end state. Proc.Natl.Acad.Sci.USA, 94, 1997
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1TJC
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![BU of 1tjc by Molmil](/molmil-images/mine/1tjc) | Crystal structure of peptide-substrate-binding domain of human type I collagen prolyl 4-hydroxylase | Descriptor: | Prolyl 4-hydroxylase alpha-1 subunit | Authors: | Pekkala, M, Hieta, R, Bergmann, U, Kivirikko, K.I, Wierenga, R.K, Myllyharju, J. | Deposit date: | 2004-06-04 | Release date: | 2004-10-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Peptide-Substrate-binding Domain of Collagen Prolyl 4-Hydroxylases Is a Tetratricopeptide Repeat Domain with Functional Aromatic Residues. J.Biol.Chem., 279, 2004
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1UXW
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![BU of 1uxw by Molmil](/molmil-images/mine/1uxw) | CRYSTAL STRUCTURE OF HLA-B*2709 COMPLEXED WITH THE LATENT MEMBRANE PROTEIN 2 PEPTIDE (LMP2) OF EPSTEIN-BARR VIRUS | Descriptor: | BETA-2-MICROGLOBULIN, GENE TERMINAL PROTEIN (MEMBRANE PROTEIN LMP-2A/LMP-2B), GLYCEROL, ... | Authors: | Hulsmeyer, M, Kozerski, C, Fiorillo, M.T, Sorrentino, R, Saenger, W, Ziegler, A, Uchanska-Ziegler, B. | Deposit date: | 2004-03-01 | Release date: | 2004-11-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Allele-Dependent Similarity between Viral and Self-Peptide Presentation by Hla-B27 Subtypes J.Biol.Chem., 280, 2005
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1UXS
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![BU of 1uxs by Molmil](/molmil-images/mine/1uxs) | CRYSTAL STRUCTURE OF HLA-B*2705 COMPLEXED WITH THE LATENT MEMBRANE PROTEIN 2 PEPTIDE (LMP2)OF EPSTEIN-BARR VIRUS | Descriptor: | BETA-2-MICROGLOBULIN, GENE TERMINAL PROTEIN (MEMBRANE PROTEIN LMP-2A/LMP-2B), GLYCEROL, ... | Authors: | Hulsmeyer, M, Kozerski, C, Fiorillo, M.T, Sorrentino, R, Saenger, W, Ziegler, A, Uchanska-Ziegler, B. | Deposit date: | 2004-03-01 | Release date: | 2004-11-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Allele-Dependent Similarity between Viral and Self-Peptide Presentation by Hla-B27 Subtypes J.Biol.Chem., 280, 2005
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2JG0
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![BU of 2jg0 by Molmil](/molmil-images/mine/2jg0) | Family 37 trehalase from Escherichia coli in complex with 1- thiatrehazolin | Descriptor: | N-[(3aS,4R,5S,6S,6aS)-4,5,6-trihydroxy-4-(hydroxymethyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]thiazol-2-yl]-alpha- D-glucopyranosylamine, PERIPLASMIC TREHALASE | Authors: | Gibson, R.P, Gloster, T.M, Roberts, S, Warren, R.A.J, Storch De Gracia, I, Garcia, A, Chiara, J.L, Davies, G.J. | Deposit date: | 2007-02-07 | Release date: | 2007-02-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors. Angew.Chem.Int.Ed.Engl., 46, 2007
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