2GD2

The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety

Summary for 2GD2

Entry DOI	10.2210/pdb2gd2/pdb
Related	1X74 2GCE 2GCI 2GD0 2GD6
Descriptor	probable alpha-methylacyl-CoA racemase MCR, ACETOACETYL-COENZYME A, GLYCEROL, ... (4 entities in total)
Functional Keywords	alpha-methylacyl-coa racemase, racemase, coa transferase, proton transfer, coenzyme a, isomerase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	158481.82
Authors	Bhaumik, P.,Wierenga, R.K. (deposition date: 2006-03-15, release date: 2007-02-20, Last modification date: 2023-10-25)
Primary citation	Bhaumik, P.,Schmitz, W.,Hassinen, A.,Hiltunen, J.K.,Conzelmann, E.,Wierenga, R.K. The Catalysis of the 1,1-Proton Transfer by alpha-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface J.Mol.Biol., 367:1145-1161, 2007 Cited by PubMed: 17320106 DOI: 10.1016/j.jmb.2007.01.062 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation