2GD2
The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006637 | biological_process | acyl-CoA metabolic process |
A | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0006629 | biological_process | lipid metabolic process |
B | 0006637 | biological_process | acyl-CoA metabolic process |
B | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
B | 0016853 | molecular_function | isomerase activity |
B | 0042803 | molecular_function | protein homodimerization activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0006629 | biological_process | lipid metabolic process |
C | 0006637 | biological_process | acyl-CoA metabolic process |
C | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
C | 0016853 | molecular_function | isomerase activity |
C | 0042803 | molecular_function | protein homodimerization activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0006629 | biological_process | lipid metabolic process |
D | 0006637 | biological_process | acyl-CoA metabolic process |
D | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
D | 0016853 | molecular_function | isomerase activity |
D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE CAA A 1751 |
Chain | Residue |
A | ILE16 |
A | ARG91 |
A | LEU92 |
A | GLY113 |
A | ALA124 |
A | GLY125 |
A | HIS126 |
A | ASP127 |
A | TYR130 |
A | ASP156 |
A | HOH1801 |
A | ARG38 |
A | HOH1826 |
A | HOH1887 |
A | HOH1920 |
A | HOH1992 |
A | HOH1999 |
A | HOH2016 |
A | HOH2048 |
A | HOH2143 |
A | ALA59 |
A | LEU61 |
A | LYS62 |
A | GLY83 |
A | TYR84 |
A | ARG85 |
A | VAL88 |
site_id | AC2 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE CAA B 1752 |
Chain | Residue |
B | ILE16 |
B | ARG38 |
B | ALA59 |
B | LEU61 |
B | LYS62 |
B | GLY83 |
B | TYR84 |
B | ARG85 |
B | VAL88 |
B | ARG91 |
B | LEU92 |
B | GLY113 |
B | GLY125 |
B | TYR130 |
B | GOL2308 |
B | HOH2350 |
B | HOH2388 |
B | HOH2402 |
B | HOH2427 |
B | HOH2451 |
B | HOH2473 |
B | HOH2505 |
B | HOH2567 |
B | HOH2613 |
B | HOH2677 |
site_id | AC3 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE CAA C 1753 |
Chain | Residue |
C | ARG38 |
C | ALA59 |
C | ASP60 |
C | LEU61 |
C | LYS62 |
C | GLY83 |
C | TYR84 |
C | ARG85 |
C | VAL88 |
C | ARG91 |
C | LEU92 |
C | GLY113 |
C | GLY125 |
C | TYR130 |
C | ASP156 |
C | GOL2307 |
C | HOH2337 |
C | HOH2367 |
C | HOH2397 |
C | HOH2434 |
C | HOH2478 |
C | HOH2499 |
C | HOH2566 |
C | HOH2642 |
site_id | AC4 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE CAA D 1754 |
Chain | Residue |
D | HOH1987 |
D | HOH2031 |
D | HOH2045 |
D | HOH2046 |
D | HOH2083 |
D | HOH2087 |
D | HOH2141 |
D | HOH2152 |
D | ILE16 |
D | ARG38 |
D | ALA59 |
D | ASP60 |
D | LEU61 |
D | LYS62 |
D | GLY83 |
D | TYR84 |
D | ARG85 |
D | VAL88 |
D | ARG91 |
D | LEU92 |
D | GLY113 |
D | GLY125 |
D | HIS126 |
D | ASP127 |
D | TYR130 |
D | ASP156 |
D | HOH1819 |
D | HOH1830 |
D | HOH1836 |
D | HOH1872 |
D | HOH1976 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL C 2307 |
Chain | Residue |
C | ILE16 |
C | HIS126 |
C | ASP127 |
C | ASP156 |
C | CAA1753 |
C | HOH2561 |
D | LEU217 |
D | ILE240 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 2308 |
Chain | Residue |
A | TYR224 |
B | ILE16 |
B | HIS126 |
B | ASP127 |
B | ASP156 |
B | CAA1752 |
B | HOH2662 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:17320106, ECO:0000305|PubMed:22360758 |
Chain | Residue | Details |
A | HIS126 | |
B | HIS126 | |
C | HIS126 | |
D | HIS126 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:17320106, ECO:0000305|PubMed:22360758 |
Chain | Residue | Details |
A | ASP156 | |
B | ASP156 | |
C | ASP156 | |
D | ASP156 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17320106, ECO:0000269|PubMed:22360758 |
Chain | Residue | Details |
A | ARG38 | |
B | GLY125 | |
C | ARG38 | |
C | ALA59 | |
C | GLY83 | |
C | ARG91 | |
C | GLY125 | |
D | ARG38 | |
D | ALA59 | |
D | GLY83 | |
D | ARG91 | |
A | ALA59 | |
D | GLY125 | |
A | GLY83 | |
A | ARG91 | |
A | GLY125 | |
B | ARG38 | |
B | ALA59 | |
B | GLY83 | |
B | ARG91 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1xvt |
Chain | Residue | Details |
A | ASP156 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1xvt |
Chain | Residue | Details |
B | ASP156 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1xvt |
Chain | Residue | Details |
C | ASP156 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1xvt |
Chain | Residue | Details |
D | ASP156 |