4RQ3
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4RR9
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![BU of 4rr9 by Molmil](/molmil-images/mine/4rr9) | N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Ser3AA (snapshot 4) | Descriptor: | MAGNESIUM ION, Probable threonine--tRNA ligase 2, SERINE-3'-AMINOADENOSINE | Authors: | Ahmad, S, Muthukumar, S, Yerabham, A.S.K, Kamarthapu, V, Sankaranarayanan, R. | Deposit date: | 2014-11-06 | Release date: | 2015-07-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme. Nat Commun, 6, 2015
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1ZFJ
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![BU of 1zfj by Molmil](/molmil-images/mine/1zfj) | INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH; EC 1.1.1.205) FROM STREPTOCOCCUS PYOGENES | Descriptor: | INOSINE MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID | Authors: | Zhang, R, Evans, G, Rotella, F.J, Westbrook, E.M, Beno, D, Huberman, E, Joachimiak, A, Collart, F.R. | Deposit date: | 1999-03-29 | Release date: | 2000-03-29 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase. Biochemistry, 38, 1999
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4RRL
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4RMB
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1ZG9
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![BU of 1zg9 by Molmil](/molmil-images/mine/1zg9) | Crystal Structure of 5-{[amino(imino)methyl]amino}-2-(sulfanylmethyl)pentanoic acid Bound to Activated Porcine Pancreatic Carboxypeptidase B | Descriptor: | 5-{[AMINO(IMINO)METHYL]AMINO}-2-(SULFANYLMETHYL)PENTANOIC ACID, ZINC ION, procarboxypeptidase B | Authors: | Adler, M, Bryant, J, Buckman, B, Islam, I, Larsen, B, Finster, S, Kent, L, May, K, Mohan, R, Yuan, S, Whitlow, M. | Deposit date: | 2005-04-20 | Release date: | 2005-07-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase b. Biochemistry, 44, 2005
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1ZC6
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![BU of 1zc6 by Molmil](/molmil-images/mine/1zc6) | Crystal Structure of Putative N-acetylglucosamine Kinase from Chromobacterium violaceum. Northeast Structural Genomics Target Cvr23. | Descriptor: | probable N-acetylglucosamine kinase | Authors: | Vorobiev, S.M, Kuzin, A, Forouhar, F, Abashidze, M, Acton, T.B, Xiao, R, Ma, L.-C, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-04-11 | Release date: | 2005-05-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of Putative N-acetylglucosamine Kinase from Chromobacterium violaceum To be Published
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4RRS
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![BU of 4rrs by Molmil](/molmil-images/mine/4rrs) | 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors | Descriptor: | (4R,4a'R,10a'S)-8'-(2-fluoropyridin-3-yl)-4a'-methyl-3',4',4a',10a'-tetrahydro-2'H-spiro[1,3-oxazole-4,10'-pyrano[3,2-b]chromen]-2-amine, Beta-secretase 1, NICKEL (II) ION | Authors: | Thomas, A.A, Hunt, K.W, Newhouse, B, Watts, R.J, Liu, X, Vigers, G.P.A, Smith, D, Rhodes, S.P, Brown, K.D, Otten, J.N, Burkard, M, Cox, A.A, Geck Do, M.K, Dutcher, D, Rana, S, DeLisle, R.K, Regal, K, Wright, A.D, Groneberg, R, Liao, J, Scearce-Levie, K, Siu, M, Purkey, H.E, Lyssikatos, J.P. | Deposit date: | 2014-11-06 | Release date: | 2014-12-03 | Last modified: | 2014-12-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | 8-Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors. J.Med.Chem., 57, 2014
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3N1C
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![BU of 3n1c by Molmil](/molmil-images/mine/3n1c) | Crystal structure of the phosphofructokinase-2 from Escherichia coli in complex with fructose-6-phosphate | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructokinase isozyme 2 | Authors: | Pereira, H.M, Cabrera, R, Caniuguir, A, Garratt, R.C, Babul, J. | Deposit date: | 2010-05-15 | Release date: | 2010-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Complex of Phosphofructokinase-2 of Escherichia coli with Fructose-6-phosphate: KINETIC AND STRUCTURAL ANALYSIS OF THE ALLOSTERIC ATP INHIBITION. J.Biol.Chem., 286, 2011
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1KFW
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3ZD0
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![BU of 3zd0 by Molmil](/molmil-images/mine/3zd0) | The Solution Structure of Monomeric Hepatitis C Virus p7 Yields Potent Inhibitors of Virion Release | Descriptor: | P7 PROTEIN | Authors: | Foster, T.L, Sthompson, G, Kalverda, A.P, Kankanala, J, Thompson, J, Barker, A.M, Clarke, D, Noerenberg, M, Pearson, A.R, Rowlands, D.J, Homans, S.W, Harris, M, Foster, R, Griffin, S.D.C. | Deposit date: | 2012-11-23 | Release date: | 2013-09-04 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structure-Guided Design Affirms Inhibitors of Hepatitis C Virus P7 as a Viable Class of Antivirals Targeting Virion Release Hepatology, 59, 2014
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1KGX
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![BU of 1kgx by Molmil](/molmil-images/mine/1kgx) | Three Dimensional Structure Analysis of the R195Q Variant of Human Pancreatic Alpha Amylase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-AMYLASE, PANCREATIC, ... | Authors: | Numao, S, Maurus, R, Sidhu, G, Wang, Y, Overall, C.M, Brayer, G.D, Withers, S.G. | Deposit date: | 2001-11-28 | Release date: | 2002-01-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase. Biochemistry, 41, 2002
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1ZHO
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![BU of 1zho by Molmil](/molmil-images/mine/1zho) | The structure of a ribosomal protein L1 in complex with mRNA | Descriptor: | 50S ribosomal protein L1, POTASSIUM ION, mRNA | Authors: | Nevskaya, N, Tishchenko, S, Volchkov, S, Kljashtorny, V, Nikonova, E, Nikonov, O, Nikulin, A, Kohrer, C, Piendl, W, Zimmermann, R, Stockley, P, Garber, M, Nikonov, S. | Deposit date: | 2005-04-26 | Release date: | 2006-05-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | New insights into the interaction of ribosomal protein L1 with RNA. J.Mol.Biol., 355, 2006
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4RU0
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![BU of 4ru0 by Molmil](/molmil-images/mine/4ru0) | The crystal structure of abc transporter permease from pseudomonas fluorescens group | Descriptor: | 3,6,9,12,15-PENTAOXAHEPTADECANE, GLYCEROL, Putative branched-chain amino acid ABC transporter, ... | Authors: | Wu, R, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-11-17 | Release date: | 2014-11-26 | Method: | X-RAY DIFFRACTION (2.442 Å) | Cite: | The crystal structure of abc transporter permease from pseudomonas fluorescens group To be Published
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4RQ2
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![BU of 4rq2 by Molmil](/molmil-images/mine/4rq2) | Human DNA Polymerase Beta With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine (8-oxoG)and dCTP soaked with MnCl2 for 35 s | Descriptor: | ACETATE ION, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), ... | Authors: | Vyas, R, Reed, A.J, Suo, Z. | Deposit date: | 2014-10-31 | Release date: | 2015-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Viewing Human DNA Polymerase beta Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography. J.Am.Chem.Soc., 137, 2015
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2DY3
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![BU of 2dy3 by Molmil](/molmil-images/mine/2dy3) | Crystal Structure of alanine racemase from Corynebacterium glutamicum | Descriptor: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Miyaguchi, I, Sasaki, C, Kato, R, Oikawa, T, Sugio, S. | Deposit date: | 2006-09-05 | Release date: | 2007-09-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of Alanine Racemase from Corynebacterium glutamicum at 2.1 A resolution To be Published
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1KHG
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![BU of 1khg by Molmil](/molmil-images/mine/1khg) | PEPCK | Descriptor: | 1,2-ETHANEDIOL, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... | Authors: | Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J. | Deposit date: | 2001-11-29 | Release date: | 2002-02-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J.Mol.Biol., 316, 2002
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3ZCR
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![BU of 3zcr by Molmil](/molmil-images/mine/3zcr) | Rabbit muscle glycogen phosphorylase b in complex with N-(4-tert- butyl-benzoyl)-N-beta-D-glucopyranosyl urea determined at 2.07 A resolution | Descriptor: | GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, INOSINIC ACID, ... | Authors: | Chrysina, E.D, Nagy, V, Felfoldi, N, Konya, B, Telepo, K, Praly, J.P, Docsa, T, Gergely, P, Alexacou, K.M, Hayes, J.M, Konstantakaki, M, Kardakaris, R, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G, Somsak, L. | Deposit date: | 2012-11-21 | Release date: | 2013-12-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents To be Published
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2EJW
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![BU of 2ejw by Molmil](/molmil-images/mine/2ejw) | Homoserine Dehydrogenase from Thermus thermophilus HB8 | Descriptor: | GLYCEROL, Homoserine dehydrogenase, MAGNESIUM ION, ... | Authors: | Omi, R, Goto, M, Miyahara, I, Hirotsu, K. | Deposit date: | 2007-03-21 | Release date: | 2008-02-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of Homoserine Dehydrogenase from Thermus thermophilus HB8 To be Published
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3ZEI
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![BU of 3zei by Molmil](/molmil-images/mine/3zei) | Structure of the Mycobacterium tuberculosis O-Acetylserine Sulfhydrylase (OASS) CysK1 in complex with a small molecule inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[(Z)-[(5Z)-5-[[2-(2-hydroxy-2-oxoethyloxy)phenyl]methylidene]-3-methyl-4-oxidanylidene-1,3-thiazolidin-2-ylidene]amino]benzoic acid, O-ACETYLSERINE SULFHYDRYLASE, ... | Authors: | Poyraz, O, Schnell, R, Schneider, G. | Deposit date: | 2012-12-05 | Release date: | 2013-08-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium Tuberculosis. J.Med.Chem., 56, 2013
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6G17
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![BU of 6g17 by Molmil](/molmil-images/mine/6g17) | Non-aged form of Torpedo californica acetylcholinesterase inhibited by nerve agent tabun | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ... | Authors: | Santoni, G, De la Mora, E, de Souza, J, Silman, I, Sussman, J, Baati, R, Weik, M, Nachon, F. | Deposit date: | 2018-03-20 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. J. Med. Chem., 61, 2018
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3ZFG
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![BU of 3zfg by Molmil](/molmil-images/mine/3zfg) | Human enterovirus 71 in complex with capsid binding inhibitor WIN51711 | Descriptor: | 5-(7-(4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, VP1, VP2, ... | Authors: | Plevka, P, Perera, R, Yap, M.L, Cardosa, J, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2012-12-11 | Release date: | 2013-03-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of Human Enterovirus 71 in Complex with a Capsid-Binding Inhibitor. Proc.Natl.Acad.Sci.USA, 110, 2013
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1ZLI
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![BU of 1zli by Molmil](/molmil-images/mine/1zli) | Crystal structure of the tick carboxypeptidase inhibitor in complex with human carboxypeptidase B | Descriptor: | Carboxypeptidase B, ZINC ION, carboxypeptidase inhibitor | Authors: | Arolas, J.L, Popowicz, G.M, Lorenzo, J, Sommerhoff, C.P, Huber, R, Aviles, F.X, Holak, T.A. | Deposit date: | 2005-05-06 | Release date: | 2005-07-05 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode J.Mol.Biol., 350, 2005
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2E0O
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![BU of 2e0o by Molmil](/molmil-images/mine/2e0o) | Mutant Human Ribonuclease 1 (V52L, D53L, N56L, F59L) | Descriptor: | GLYCEROL, Ribonuclease, SULFATE ION | Authors: | Yamada, H, Tamada, T, Kosaka, M, Kuroki, R. | Deposit date: | 2006-10-10 | Release date: | 2007-08-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines Protein Sci., 16, 2007
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1ZNG
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![BU of 1zng by Molmil](/molmil-images/mine/1zng) | Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex | Descriptor: | CADMIUM ION, HEPTAN-1-OL, Major Urinary Protein | Authors: | Malham, R, Johnstone, S, Bingham, R.J, Barratt, E, Phillips, S.E, Laughton, C.A, Homans, S.W. | Deposit date: | 2005-05-11 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex. J.Am.Chem.Soc., 127, 2005
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