3ZD0

The Solution Structure of Monomeric Hepatitis C Virus p7 Yields Potent Inhibitors of Virion Release

Summary for 3ZD0

• Entry DOI: 10.2210/pdb3zd0/pdb
• NMR Information: BMRB: 18863
• Descriptor: P7 PROTEIN (1 entity in total)
• Functional Keywords: transport protein, antiviral, ion channel, viroporin
• Biological source: HEPATITIS C VIRUS (HCV)
• Total number of polymer chains: 1
• Total formula weight: 9065.47

Authors

Foster, T.L.,Sthompson, G.,Kalverda, A.P.,Kankanala, J.,Thompson, J.,Barker, A.M.,Clarke, D.,Noerenberg, M.,Pearson, A.R.,Rowlands, D.J.,Homans, S.W.,Harris, M.,Foster, R.,Griffin, S.D.C. (deposition date: 2012-11-23, release date: 2013-09-04, Last modification date: 2023-06-14)

• Primary citation: Foster, T.L.,Thompson, G.S.,Kalverda, A.P.,Kankanala, J.,Bentham, M.,Wetherill, L.F.,Thompson, J.,Barker, A.M.,Clarke, D.,Noerenberg, M.,Pearson, A.R.,Rowlands, D.J.,Homans, S.W.,Harris, M.,Foster, R.,Griffin, S.D.C.; Structure-Guided Design Affirms Inhibitors of Hepatitis C Virus P7 as a Viable Class of Antivirals Targeting Virion Release; Hepatology, 59:408-, 2014; PubMed: 24022996; DOI: 10.1002/HEP.26685

Experimental method

SOLUTION NMR