3ZCR
Rabbit muscle glycogen phosphorylase b in complex with N-(4-tert- butyl-benzoyl)-N-beta-D-glucopyranosyl urea determined at 2.07 A resolution
Summary for 3ZCR
Entry DOI | 10.2210/pdb3zcr/pdb |
Related | 3ZCP 3ZCQ 3ZCS 3ZCT 3ZCU 3ZCV |
Descriptor | GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, INOSINIC ACID, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total) |
Functional Keywords | transferase, n-acyl-n-beta-d-glucopyranosyl ureas, glycogen phosphorylase, inhibitors, hypoglycaemic agents, structure- based ligand design |
Biological source | ORYCTOLAGUS CUNICULUS (RABBIT) |
Total number of polymer chains | 1 |
Total formula weight | 98400.15 |
Authors | Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L. (deposition date: 2012-11-21, release date: 2013-12-11, Last modification date: 2023-12-20) |
Primary citation | Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L. Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents To be Published, |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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