3ZEI

Structure of the Mycobacterium tuberculosis O-Acetylserine Sulfhydrylase (OASS) CysK1 in complex with a small molecule inhibitor

Summary for 3ZEI

Entry DOI	10.2210/pdb3zei/pdb
Descriptor	O-ACETYLSERINE SULFHYDRYLASE, PYRIDOXAL-5'-PHOSPHATE, 3-[(Z)-[(5Z)-5-[[2-(2-hydroxy-2-oxoethyloxy)phenyl]methylidene]-3-methyl-4-oxidanylidene-1,3-thiazolidin-2-ylidene]amino]benzoic acid, ... (5 entities in total)
Functional Keywords	hydrolase, inhibitor
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	1
Total formula weight	33681.52
Authors	Poyraz, O.,Schnell, R.,Schneider, G. (deposition date: 2012-12-05, release date: 2013-08-07, Last modification date: 2023-12-20)
Primary citation	Poyraz, O.,Jeankumar, V.U.,Saxena, S.,Schnell, R.,Haraldsson, M.,Yogeeswari, P.,Sriram, D.,Schneider, G. Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium Tuberculosis. J.Med.Chem., 56:6457-, 2013 Cited by PubMed: 23879381 DOI: 10.1021/JM400710K PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation