1THR
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![BU of 1thr by Molmil](/molmil-images/mine/1thr) | STRUCTURES OF THROMBIN COMPLEXES WITH A DESIGNED AND A NATURAL EXOSITE INHIBITOR | Descriptor: | ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRULLIN | Authors: | Qiu, X, Yin, M, Padmanabhan, K.P, Krstenansky, J.L, Tulinsky, A. | Deposit date: | 1993-06-16 | Release date: | 1994-01-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor. J.Biol.Chem., 268, 1993
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6JH7
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![BU of 6jh7 by Molmil](/molmil-images/mine/6jh7) | Crystal structure of AerF from Microcystis aeruginosa | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, Short chain dehydrogenase family protein, ... | Authors: | Qiu, X. | Deposit date: | 2019-02-17 | Release date: | 2019-11-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin J.Struct.Biol., 2019
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6JHB
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6JHA
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![BU of 6jha by Molmil](/molmil-images/mine/6jha) | Crystal structure of NADPH bound AerF from Microcystis aeruginosa | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase family protein, TRIETHYLENE GLYCOL | Authors: | Qiu, X. | Deposit date: | 2019-02-17 | Release date: | 2019-11-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin J.Struct.Biol., 2019
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1JIL
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![BU of 1jil by Molmil](/molmil-images/mine/1jil) | Crystal structure of S. aureus TyrRS in complex with SB284485 | Descriptor: | [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]- (3,4,5-TRIHYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YL)- ACETIC ACID, tyrosyl-tRNA synthetase | Authors: | Qiu, X, Janson, C.A, Smith, W.W, Jarvest, R.L. | Deposit date: | 2001-07-02 | Release date: | 2001-10-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci., 10, 2001
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1ABI
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1JIJ
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![BU of 1jij by Molmil](/molmil-images/mine/1jij) | Crystal structure of S. aureus TyrRS in complex with SB-239629 | Descriptor: | [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]-(1,3,4,5-TETRAHYDROXY-4-HYDROXYMETHYL-PIPERIDIN-2-YL)- ACETIC ACID, tyrosyl-tRNA synthetase | Authors: | Qiu, X, Janson, C.A, Smith, W.W, Jarvest, R.L. | Deposit date: | 2001-07-02 | Release date: | 2001-10-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci., 10, 2001
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1JII
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![BU of 1jii by Molmil](/molmil-images/mine/1jii) | Crystal structure of S. aureus TyrRS in complex with SB-219383 | Descriptor: | [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]- (2,4,5,8-TETRAHYDROXY-7-OXA-2-AZA-BICYCLO[3.2.1]OCT-3-YL)- ACETIC ACID, tyrosyl-tRNA synthetase | Authors: | Qiu, X, Janson, C.A, Smith, W.W, Jarvest, R.L. | Deposit date: | 2001-07-02 | Release date: | 2001-10-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci., 10, 2001
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1ABJ
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1JIK
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![BU of 1jik by Molmil](/molmil-images/mine/1jik) | Crystal structure of S. aureus TyrRS in complex with SB-243545 | Descriptor: | [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]-(1,3,4,5-TETRAHYDROXY-4-HYDROXYMETHYL-PIPERIDIN-2-YL)- ACETIC ACID BUTYL ESTER, tyrosyl-tRNA synthetase | Authors: | Qiu, X, Janson, C.A, Smith, W.W, Jarvest, R.L. | Deposit date: | 2001-07-02 | Release date: | 2001-10-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci., 10, 2001
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2OBD
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![BU of 2obd by Molmil](/molmil-images/mine/2obd) | Crystal Structure of Cholesteryl Ester Transfer Protein | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Qiu, X. | Deposit date: | 2006-12-18 | Release date: | 2007-01-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat.Struct.Mol.Biol., 14, 2007
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1T8K
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![BU of 1t8k by Molmil](/molmil-images/mine/1t8k) | Crystal Structure of apo acyl carrier protein from E. coli | Descriptor: | Acyl carrier protein, IMIDAZOLE, ZINC ION | Authors: | Qiu, X, Janson, C.A. | Deposit date: | 2004-05-13 | Release date: | 2004-09-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structure of apo acyl carrier protein and a proposal to engineer protein crystallization through metal ions. Acta Crystallogr.,Sect.D, 60, 2004
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1TMB
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![BU of 1tmb by Molmil](/molmil-images/mine/1tmb) | MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A | Descriptor: | ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUGEN, ... | Authors: | Qiu, X, Padmanabhan, K.P, Maryanoff, B.E, Tulinsky, A. | Deposit date: | 1993-05-27 | Release date: | 1994-01-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. Proc.Natl.Acad.Sci.USA, 90, 1993
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1ZOW
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![BU of 1zow by Molmil](/molmil-images/mine/1zow) | Crystal Structure of S. aureus FabH, beta-ketoacyl carrier protein synthase III | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase III | Authors: | Qiu, X, Choudhry, A.E, Janson, C.A, Grooms, M, Daines, R.A, Lonsdale, J.T, Khandekar, S.S. | Deposit date: | 2005-05-15 | Release date: | 2005-08-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Protein Sci., 14, 2005
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5ID6
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![BU of 5id6 by Molmil](/molmil-images/mine/5id6) | Structure of Cpf1/RNA Complex | Descriptor: | Cpf1, MAGNESIUM ION, RNA (5'-R(P*AP*AP*UP*UP*UP*CP*UP*AP*CP*UP*AP*AP*GP*UP*GP*UP*AP*GP*AP*UP*C)-3') | Authors: | Dong, D, Ren, K, Qiu, X, Wang, J, Huang, Z. | Deposit date: | 2016-02-24 | Release date: | 2016-04-27 | Last modified: | 2016-05-11 | Method: | X-RAY DIFFRACTION (2.382 Å) | Cite: | The crystal structure of Cpf1 in complex with CRISPR RNA Nature, 532, 2016
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5GZO
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![BU of 5gzo by Molmil](/molmil-images/mine/5gzo) | Structure of neutralizing antibody bound to Zika envelope protein | Descriptor: | Antibody heavy chain, Antibody light chain, Genome polyprotein | Authors: | Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. | Deposit date: | 2016-09-29 | Release date: | 2017-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.755 Å) | Cite: | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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5GZN
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![BU of 5gzn by Molmil](/molmil-images/mine/5gzn) | Structure of neutralizing antibody bound to Zika envelope protein | Descriptor: | Antibody Heavy chain, Antibody light chain, Genome polyprotein | Authors: | Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. | Deposit date: | 2016-09-29 | Release date: | 2016-12-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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7KDP
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![BU of 7kdp by Molmil](/molmil-images/mine/7kdp) | HCMV prefusion gB in complex with fusion inhibitor WAY-174865 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein B, ... | Authors: | Liu, Y, Heim, P.K, Che, Y, Chi, X, Qiu, X, Han, S, Dormitzer, P.R, Yang, X. | Deposit date: | 2020-10-09 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion. Sci Adv, 7, 2021
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7KDD
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![BU of 7kdd by Molmil](/molmil-images/mine/7kdd) | HCMV postfusion gB in complex with SM5-1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein B, ... | Authors: | Liu, Y, Heim, P.K, Che, Y, Chi, X, Qiu, X, Han, S, Dormitzer, P.R, Yang, X. | Deposit date: | 2020-10-08 | Release date: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion. Sci Adv, 7, 2021
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4EWS
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5BTR
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![BU of 5btr by Molmil](/molmil-images/mine/5btr) | Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide | Descriptor: | AMC-containing peptide, NAD-dependent protein deacetylase sirtuin-1, RESVERATROL, ... | Authors: | Cao, D, Wang, M, Qiu, X, Liu, D, Jiang, H, Yang, N, Xu, R.M. | Deposit date: | 2015-06-03 | Release date: | 2015-07-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol Genes Dev., 29, 2015
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1LX6
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8IVQ
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![BU of 8ivq by Molmil](/molmil-images/mine/8ivq) | Cryo-EM structure of mouse BIRC6, Global map | Descriptor: | Isoform 2 of Baculoviral IAP repeat-containing protein 6 | Authors: | Liu, S, Jiang, T, Bu, F, Zhao, J, Wang, G, Li, N, Gao, N, Qiu, X. | Deposit date: | 2023-03-28 | Release date: | 2024-01-24 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy. Nat Commun, 15, 2024
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1AT3
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![BU of 1at3 by Molmil](/molmil-images/mine/1at3) | HERPES SIMPLEX VIRUS TYPE II PROTEASE | Descriptor: | DIISOPROPYL PHOSPHONATE, HERPES SIMPLEX VIRUS TYPE II PROTEASE | Authors: | Hoog, S, Smith, W.W, Qiu, X, Abdel-Meguid, S.S. | Deposit date: | 1997-08-16 | Release date: | 1998-10-14 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex. Biochemistry, 36, 1997
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1A36
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![BU of 1a36 by Molmil](/molmil-images/mine/1a36) | TOPOISOMERASE I/DNA COMPLEX | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*C P*TP*TP*TP*TP*T)- 3'), TOPOISOMERASE I | Authors: | Stewart, L, Redinbo, M.R, Qiu, X, Champoux, J.J, Hol, W.G.J. | Deposit date: | 1998-01-29 | Release date: | 1998-08-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A model for the mechanism of human topoisomerase I. Science, 279, 1998
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