3BXJ
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![BU of 3bxj by Molmil](/molmil-images/mine/3bxj) | Crystal Structure of the C2-GAP Fragment of synGAP | Descriptor: | Ras GTPase-activating protein SynGAP | Authors: | Pena, V, Hothorn, M, Eberth, A, Kaschau, N, Parret, A, Gremer, L, Bonneau, F, Ahmadian, M.R, Scheffzek, K. | Deposit date: | 2008-01-14 | Release date: | 2008-03-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. Embo Rep., 9, 2008
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3IM2
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![BU of 3im2 by Molmil](/molmil-images/mine/3im2) | |
3IM1
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![BU of 3im1 by Molmil](/molmil-images/mine/3im1) | |
2OG4
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![BU of 2og4 by Molmil](/molmil-images/mine/2og4) | |
3E9L
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![BU of 3e9l by Molmil](/molmil-images/mine/3e9l) | Crystal Structure of Human Prp8, Residues 1755-2016 | Descriptor: | CHLORIDE ION, Pre-mRNA-processing-splicing factor 8, SODIUM ION | Authors: | Pena, V, Rozov, A, Wahl, M.C. | Deposit date: | 2008-08-22 | Release date: | 2008-10-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure and function of an RNase H domain at the heart of the spliceosome. Embo J., 27, 2008
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3E9O
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3E9P
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![BU of 3e9p by Molmil](/molmil-images/mine/3e9p) | |
8CH6
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![BU of 8ch6 by Molmil](/molmil-images/mine/8ch6) | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex). | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Cretu, C, Schmitzova, J, Pena, V. | Deposit date: | 2023-02-07 | Release date: | 2023-05-10 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural basis of catalytic activation in human splicing. Nature, 617, 2023
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4PJ3
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![BU of 4pj3 by Molmil](/molmil-images/mine/4pj3) | Structural insight into the function and evolution of the spliceosomal helicase Aquarius, Structure of Aquarius in complex with AMPPNP | Descriptor: | Intron-binding protein aquarius, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | De, I, Bessonov, S, Hofele, R, dos Santos, K.F, Will, C.L, Urlaub, H, Luhrmann, R, Pena, V. | Deposit date: | 2014-05-11 | Release date: | 2015-01-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nat.Struct.Mol.Biol., 22, 2015
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7QTT
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![BU of 7qtt by Molmil](/molmil-images/mine/7qtt) | |
5HY7
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![BU of 5hy7 by Molmil](/molmil-images/mine/5hy7) | |
6SP0
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![BU of 6sp0 by Molmil](/molmil-images/mine/6sp0) | |
5IFE
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![BU of 5ife by Molmil](/molmil-images/mine/5ife) | Crystal structure of the human SF3b core complex | Descriptor: | PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... | Authors: | Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V. | Deposit date: | 2016-02-25 | Release date: | 2016-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations. Mol.Cell, 64, 2016
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7OA3
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![BU of 7oa3 by Molmil](/molmil-images/mine/7oa3) | Crystal structure of Chili RNA aptamer in complex with DMHBO+ (Iridium hexammine co-crystallized form) | Descriptor: | Chili RNA Aptamer, DMHBO+, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Mieczkowski, M, Pena, V, Hoebartner, C. | Deposit date: | 2021-04-19 | Release date: | 2021-06-16 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine. Nat Commun, 12, 2021
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7OAX
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![BU of 7oax by Molmil](/molmil-images/mine/7oax) | Crystal structure of the Chili RNA aptamer in complex with DMHBO+ | Descriptor: | CHLORIDE ION, Chili RNA Aptamer, DMHBO+, ... | Authors: | Mieczkowski, M, Pena, V, Hoebartner, C. | Deposit date: | 2021-04-20 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine. Nat Commun, 12, 2021
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5M8C
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![BU of 5m8c by Molmil](/molmil-images/mine/5m8c) | Spliceosome component | Descriptor: | Pre-mRNA-processing factor 19 | Authors: | Moura, T.R, Pena, V. | Deposit date: | 2016-10-28 | Release date: | 2018-02-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors. Mol. Cell, 69, 2018
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7OPI
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7ONB
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![BU of 7onb by Molmil](/molmil-images/mine/7onb) | Structure of the U2 5' module of the A3'-SSA complex | Descriptor: | MINX, PHD finger-like domain-containing protein 5A, RNU2, ... | Authors: | Cretu, C, Pena, V. | Deposit date: | 2021-05-25 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
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7OMF
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![BU of 7omf by Molmil](/molmil-images/mine/7omf) | Structure of a minimal SF3B core in complex with sudemycin D6 (form I) | Descriptor: | PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ... | Authors: | Cretu, C, Pena, V. | Deposit date: | 2021-05-21 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors. Nat Commun, 12, 2021
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5M88
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![BU of 5m88 by Molmil](/molmil-images/mine/5m88) | Spliceosome component | Descriptor: | Core | Authors: | Moura, T.R, Pena, V. | Deposit date: | 2016-10-28 | Release date: | 2018-02-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors. Mol. Cell, 69, 2018
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5M89
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![BU of 5m89 by Molmil](/molmil-images/mine/5m89) | Spliceosome component | Descriptor: | Spliceosome WD40 Sc | Authors: | Moura, T.R, Pena, V. | Deposit date: | 2016-10-28 | Release date: | 2018-03-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.605 Å) | Cite: | Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors. Mol. Cell, 69, 2018
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7OAW
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![BU of 7oaw by Molmil](/molmil-images/mine/7oaw) | Crystal structure of the Chili RNA aptamer in complex with DMHBI+ | Descriptor: | CHLORIDE ION, Chili RNA Aptamer, DMHBI+, ... | Authors: | Mieczkowski, M, Pena, V, Hoebartner, C. | Deposit date: | 2021-04-20 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine. Nat Commun, 12, 2021
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7OAV
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![BU of 7oav by Molmil](/molmil-images/mine/7oav) | Crystal structure of Chili RNA aptamer in complex with DMHBO+ (Iridium III hexammine soaking crystal form) | Descriptor: | CHLORIDE ION, Chili RNA Aptamer, DMHBO+, ... | Authors: | Mieczkowski, M, Pena, V, Hoebartner, C. | Deposit date: | 2021-04-20 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine. Nat Commun, 12, 2021
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4F92
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![BU of 4f92 by Molmil](/molmil-images/mine/4f92) | Brr2 Helicase Region S1087L | Descriptor: | SULFANILAMIDE, U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C. | Deposit date: | 2012-05-18 | Release date: | 2012-10-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.662 Å) | Cite: | Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proc.Natl.Acad.Sci.USA, 109, 2012
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4F91
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![BU of 4f91 by Molmil](/molmil-images/mine/4f91) | Brr2 Helicase Region | Descriptor: | U5 small nuclear ribonucleoprotein 200 kDa helicase | Authors: | Santos, K.F, Jovin, S.M, Weber, G, Pena, V, Luehrmann, R, Wahl, M.C. | Deposit date: | 2012-05-18 | Release date: | 2012-10-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.697 Å) | Cite: | Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proc.Natl.Acad.Sci.USA, 109, 2012
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