8CH6

Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).

This is a non-PDB format compatible entry.

Summary for 8CH6

• Entry DOI: 10.2210/pdb8ch6/pdb
• EMDB information: 16658
• Descriptor: Small nuclear ribonucleoprotein E, Splicing factor 3B subunit 1, PHD finger-like domain-containing protein 5A, ... (53 entities in total)
• Functional Keywords: activated spliceosome, aquarius, prp2, splicing
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 59
• Total formula weight: 3668283.05

Authors

Cretu, C.,Schmitzova, J.,Pena, V. (deposition date: 2023-02-07, release date: 2023-05-10, Last modification date: 2023-06-14)

• Primary citation: Schmitzova, J.,Cretu, C.,Dienemann, C.,Urlaub, H.,Pena, V.; Structural basis of catalytic activation in human splicing.; Nature, 617:842-850, 2023; PubMed: 37165190; DOI: 10.1038/s41586-023-06049-w

Experimental method

ELECTRON MICROSCOPY (5.9 Å)