8CH6

Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000244	biological_process	spliceosomal tri-snRNP complex assembly
1	0000245	biological_process	spliceosomal complex assembly
1	0000387	biological_process	spliceosomal snRNP assembly
1	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
1	0000398	biological_process	mRNA splicing, via spliceosome
1	0003723	molecular_function	RNA binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005681	cellular_component	spliceosomal complex
1	0005682	cellular_component	U5 snRNP
1	0005683	cellular_component	U7 snRNP
1	0005684	cellular_component	U2-type spliceosomal complex
1	0005685	cellular_component	U1 snRNP
1	0005686	cellular_component	U2 snRNP
1	0005687	cellular_component	U4 snRNP
1	0005689	cellular_component	U12-type spliceosomal complex
1	0005697	cellular_component	telomerase holoenzyme complex
1	0005829	cellular_component	cytosol
1	0006397	biological_process	mRNA processing
1	0008380	biological_process	RNA splicing
1	0030532	cellular_component	small nuclear ribonucleoprotein complex
1	0034709	cellular_component	methylosome
1	0034715	cellular_component	pICln-Sm protein complex
1	0034719	cellular_component	SMN-Sm protein complex
1	0036261	biological_process	7-methylguanosine cap hypermethylation
1	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
1	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
1	0071005	cellular_component	U2-type precatalytic spliceosome
1	0071007	cellular_component	U2-type catalytic step 2 spliceosome
1	0071011	cellular_component	precatalytic spliceosome
1	0071013	cellular_component	catalytic step 2 spliceosome
1	0071045	biological_process	nuclear histone mRNA catabolic process
1	1903241	biological_process	U2-type prespliceosome assembly
1	1990904	cellular_component	ribonucleoprotein complex
2	0000244	biological_process	spliceosomal tri-snRNP complex assembly
2	0000245	biological_process	spliceosomal complex assembly
2	0000387	biological_process	spliceosomal snRNP assembly
2	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
2	0000398	biological_process	mRNA splicing, via spliceosome
2	0003723	molecular_function	RNA binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005681	cellular_component	spliceosomal complex
2	0005683	cellular_component	U7 snRNP
2	0005684	cellular_component	U2-type spliceosomal complex
2	0005685	cellular_component	U1 snRNP
2	0005687	cellular_component	U4 snRNP
2	0005689	cellular_component	U12-type spliceosomal complex
2	0005829	cellular_component	cytosol
2	0006397	biological_process	mRNA processing
2	0008380	biological_process	RNA splicing
2	0022618	biological_process	protein-RNA complex assembly
2	0030532	cellular_component	small nuclear ribonucleoprotein complex
2	0034709	cellular_component	methylosome
2	0034715	cellular_component	pICln-Sm protein complex
2	0034719	cellular_component	SMN-Sm protein complex
2	0036261	biological_process	7-methylguanosine cap hypermethylation
2	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
2	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
2	0071005	cellular_component	U2-type precatalytic spliceosome
2	0071007	cellular_component	U2-type catalytic step 2 spliceosome
2	0071013	cellular_component	catalytic step 2 spliceosome
2	0071045	biological_process	nuclear histone mRNA catabolic process
2	1903241	biological_process	U2-type prespliceosome assembly
2	1990904	cellular_component	ribonucleoprotein complex
3	0000243	cellular_component	commitment complex
3	0000244	biological_process	spliceosomal tri-snRNP complex assembly
3	0000245	biological_process	spliceosomal complex assembly
3	0000387	biological_process	spliceosomal snRNP assembly
3	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
3	0000398	biological_process	mRNA splicing, via spliceosome
3	0003723	molecular_function	RNA binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005681	cellular_component	spliceosomal complex
3	0005682	cellular_component	U5 snRNP
3	0005683	cellular_component	U7 snRNP
3	0005684	cellular_component	U2-type spliceosomal complex
3	0005685	cellular_component	U1 snRNP
3	0005686	cellular_component	U2 snRNP
3	0005687	cellular_component	U4 snRNP
3	0005689	cellular_component	U12-type spliceosomal complex
3	0005697	cellular_component	telomerase holoenzyme complex
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0006396	biological_process	RNA processing
3	0006397	biological_process	mRNA processing
3	0006479	biological_process	protein methylation
3	0008380	biological_process	RNA splicing
3	0016604	cellular_component	nuclear body
3	0019899	molecular_function	enzyme binding
3	0030532	cellular_component	small nuclear ribonucleoprotein complex
3	0034709	cellular_component	methylosome
3	0034715	cellular_component	pICln-Sm protein complex
3	0034719	cellular_component	SMN-Sm protein complex
3	0036261	biological_process	7-methylguanosine cap hypermethylation
3	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
3	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
3	0070034	molecular_function	telomerase RNA binding
3	0071005	cellular_component	U2-type precatalytic spliceosome
3	0071007	cellular_component	U2-type catalytic step 2 spliceosome
3	0071011	cellular_component	precatalytic spliceosome
3	0071013	cellular_component	catalytic step 2 spliceosome
3	0071045	biological_process	nuclear histone mRNA catabolic process
3	0071208	molecular_function	histone pre-mRNA DCP binding
3	0071209	molecular_function	U7 snRNA binding
3	0097526	cellular_component	spliceosomal tri-snRNP complex
3	1903241	biological_process	U2-type prespliceosome assembly
3	1990904	cellular_component	ribonucleoprotein complex
4	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4	0000245	biological_process	spliceosomal complex assembly
4	0000387	biological_process	spliceosomal snRNP assembly
4	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4	0000398	biological_process	mRNA splicing, via spliceosome
4	0003723	molecular_function	RNA binding
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005681	cellular_component	spliceosomal complex
4	0005682	cellular_component	U5 snRNP
4	0005684	cellular_component	U2-type spliceosomal complex
4	0005685	cellular_component	U1 snRNP
4	0005686	cellular_component	U2 snRNP
4	0005687	cellular_component	U4 snRNP
4	0005689	cellular_component	U12-type spliceosomal complex
4	0005829	cellular_component	cytosol
4	0006397	biological_process	mRNA processing
4	0008380	biological_process	RNA splicing
4	0030532	cellular_component	small nuclear ribonucleoprotein complex
4	0034709	cellular_component	methylosome
4	0034715	cellular_component	pICln-Sm protein complex
4	0034719	cellular_component	SMN-Sm protein complex
4	0036261	biological_process	7-methylguanosine cap hypermethylation
4	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4	0070062	cellular_component	extracellular exosome
4	0071005	cellular_component	U2-type precatalytic spliceosome
4	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4	0071011	cellular_component	precatalytic spliceosome
4	0071013	cellular_component	catalytic step 2 spliceosome
4	0097525	cellular_component	spliceosomal snRNP complex
4	1903241	biological_process	U2-type prespliceosome assembly
4	1990904	cellular_component	ribonucleoprotein complex
5	0000243	cellular_component	commitment complex
5	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5	0000245	biological_process	spliceosomal complex assembly
5	0000387	biological_process	spliceosomal snRNP assembly
5	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5	0000398	biological_process	mRNA splicing, via spliceosome
5	0003723	molecular_function	RNA binding
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005681	cellular_component	spliceosomal complex
5	0005682	cellular_component	U5 snRNP
5	0005684	cellular_component	U2-type spliceosomal complex
5	0005685	cellular_component	U1 snRNP
5	0005686	cellular_component	U2 snRNP
5	0005687	cellular_component	U4 snRNP
5	0005689	cellular_component	U12-type spliceosomal complex
5	0005737	cellular_component	cytoplasm
5	0005829	cellular_component	cytosol
5	0006396	biological_process	RNA processing
5	0006397	biological_process	mRNA processing
5	0008380	biological_process	RNA splicing
5	0030532	cellular_component	small nuclear ribonucleoprotein complex
5	0034709	cellular_component	methylosome
5	0034715	cellular_component	pICln-Sm protein complex
5	0034719	cellular_component	SMN-Sm protein complex
5	0036261	biological_process	7-methylguanosine cap hypermethylation
5	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5	0071005	cellular_component	U2-type precatalytic spliceosome
5	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5	0071011	cellular_component	precatalytic spliceosome
5	0071013	cellular_component	catalytic step 2 spliceosome
5	0097526	cellular_component	spliceosomal tri-snRNP complex
5	1903241	biological_process	U2-type prespliceosome assembly
5	1990446	molecular_function	U1 snRNP binding
5	1990904	cellular_component	ribonucleoprotein complex
8	0000244	biological_process	spliceosomal tri-snRNP complex assembly
8	0000245	biological_process	spliceosomal complex assembly
8	0000387	biological_process	spliceosomal snRNP assembly
8	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
8	0000398	biological_process	mRNA splicing, via spliceosome
8	0003723	molecular_function	RNA binding
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005681	cellular_component	spliceosomal complex
8	0005682	cellular_component	U5 snRNP
8	0005683	cellular_component	U7 snRNP
8	0005684	cellular_component	U2-type spliceosomal complex
8	0005685	cellular_component	U1 snRNP
8	0005686	cellular_component	U2 snRNP
8	0005687	cellular_component	U4 snRNP
8	0005689	cellular_component	U12-type spliceosomal complex
8	0005697	cellular_component	telomerase holoenzyme complex
8	0005737	cellular_component	cytoplasm
8	0005829	cellular_component	cytosol
8	0006397	biological_process	mRNA processing
8	0006479	biological_process	protein methylation
8	0008380	biological_process	RNA splicing
8	0030532	cellular_component	small nuclear ribonucleoprotein complex
8	0034709	cellular_component	methylosome
8	0034719	cellular_component	SMN-Sm protein complex
8	0036261	biological_process	7-methylguanosine cap hypermethylation
8	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
8	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
8	0070034	molecular_function	telomerase RNA binding
8	0070990	molecular_function	snRNP binding
8	0071004	cellular_component	U2-type prespliceosome
8	0071005	cellular_component	U2-type precatalytic spliceosome
8	0071007	cellular_component	U2-type catalytic step 2 spliceosome
8	0071013	cellular_component	catalytic step 2 spliceosome
8	0071045	biological_process	nuclear histone mRNA catabolic process
8	0071204	cellular_component	histone pre-mRNA 3'end processing complex
8	0071208	molecular_function	histone pre-mRNA DCP binding
8	1903241	biological_process	U2-type prespliceosome assembly
8	1990446	molecular_function	U1 snRNP binding
8	1990447	molecular_function	U2 snRNP binding
8	1990904	cellular_component	ribonucleoprotein complex
9	0000244	biological_process	spliceosomal tri-snRNP complex assembly
9	0000245	biological_process	spliceosomal complex assembly
9	0000387	biological_process	spliceosomal snRNP assembly
9	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
9	0000398	biological_process	mRNA splicing, via spliceosome
9	0003723	molecular_function	RNA binding
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005681	cellular_component	spliceosomal complex
9	0005682	cellular_component	U5 snRNP
9	0005683	cellular_component	U7 snRNP
9	0005684	cellular_component	U2-type spliceosomal complex
9	0005685	cellular_component	U1 snRNP
9	0005686	cellular_component	U2 snRNP
9	0005687	cellular_component	U4 snRNP
9	0005689	cellular_component	U12-type spliceosomal complex
9	0005829	cellular_component	cytosol
9	0006397	biological_process	mRNA processing
9	0008380	biological_process	RNA splicing
9	0030532	cellular_component	small nuclear ribonucleoprotein complex
9	0034709	cellular_component	methylosome
9	0034719	cellular_component	SMN-Sm protein complex
9	0036261	biological_process	7-methylguanosine cap hypermethylation
9	0043186	cellular_component	P granule
9	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
9	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
9	0071004	cellular_component	U2-type prespliceosome
9	0071005	cellular_component	U2-type precatalytic spliceosome
9	0071007	cellular_component	U2-type catalytic step 2 spliceosome
9	0071011	cellular_component	precatalytic spliceosome
9	0071013	cellular_component	catalytic step 2 spliceosome
9	0071045	biological_process	nuclear histone mRNA catabolic process
9	0097526	cellular_component	spliceosomal tri-snRNP complex
9	1903241	biological_process	U2-type prespliceosome assembly
9	1990904	cellular_component	ribonucleoprotein complex
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003676	molecular_function	nucleic acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005684	cellular_component	U2-type spliceosomal complex
A	0005686	cellular_component	U2 snRNP
A	0005689	cellular_component	U12-type spliceosomal complex
A	0005730	cellular_component	nucleolus
A	0006282	biological_process	regulation of DNA repair
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0030620	molecular_function	U2 snRNA binding
A	0042177	biological_process	negative regulation of protein catabolic process
A	0043484	biological_process	regulation of RNA splicing
A	0044877	molecular_function	protein-containing complex binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	1903241	biological_process	U2-type prespliceosome assembly
B	0000387	biological_process	spliceosomal snRNP assembly
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005684	cellular_component	U2-type spliceosomal complex
B	0005686	cellular_component	U2 snRNP
B	0005689	cellular_component	U12-type spliceosomal complex
B	0006282	biological_process	regulation of DNA repair
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0043484	biological_process	regulation of RNA splicing
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071011	cellular_component	precatalytic spliceosome
B	1903241	biological_process	U2-type prespliceosome assembly
B	1990935	molecular_function	splicing factor binding
C	0000245	biological_process	spliceosomal complex assembly
C	0000375	biological_process	RNA splicing, via transesterification reactions
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000785	cellular_component	chromatin
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005684	cellular_component	U2-type spliceosomal complex
C	0005686	cellular_component	U2 snRNP
C	0005689	cellular_component	U12-type spliceosomal complex
C	0005730	cellular_component	nucleolus
C	0006338	biological_process	chromatin remodeling
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0016607	cellular_component	nuclear speck
C	0031981	cellular_component	nuclear lumen
C	0034693	cellular_component	U11/U12 snRNP
C	0036002	molecular_function	pre-mRNA binding
C	0045943	biological_process	positive regulation of transcription by RNA polymerase I
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0045945	biological_process	positive regulation of transcription by RNA polymerase III
C	0071004	cellular_component	U2-type prespliceosome
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	1903241	biological_process	U2-type prespliceosome assembly
C	1990935	molecular_function	splicing factor binding
D	0000387	biological_process	spliceosomal snRNP assembly
D	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005684	cellular_component	U2-type spliceosomal complex
D	0005686	cellular_component	U2 snRNP
D	0005689	cellular_component	U12-type spliceosomal complex
D	0006351	biological_process	DNA-templated transcription
D	0006397	biological_process	mRNA processing
D	0008270	molecular_function	zinc ion binding
D	0008380	biological_process	RNA splicing
D	0016363	cellular_component	nuclear matrix
D	0016607	cellular_component	nuclear speck
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046872	molecular_function	metal ion binding
D	0048863	biological_process	stem cell differentiation
D	0071005	cellular_component	U2-type precatalytic spliceosome
D	0071011	cellular_component	precatalytic spliceosome
D	1903241	biological_process	U2-type prespliceosome assembly
E	0000387	biological_process	spliceosomal snRNP assembly
E	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005684	cellular_component	U2-type spliceosomal complex
E	0005686	cellular_component	U2 snRNP
E	0005689	cellular_component	U12-type spliceosomal complex
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0016607	cellular_component	nuclear speck
E	0071005	cellular_component	U2-type precatalytic spliceosome
E	0071011	cellular_component	precatalytic spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
E	1903241	biological_process	U2-type prespliceosome assembly
F	0000375	biological_process	RNA splicing, via transesterification reactions
F	0000387	biological_process	spliceosomal snRNP assembly
F	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005684	cellular_component	U2-type spliceosomal complex
F	0005686	cellular_component	U2 snRNP
F	0005689	cellular_component	U12-type spliceosomal complex
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0071011	cellular_component	precatalytic spliceosome
F	1903241	biological_process	U2-type prespliceosome assembly
F	1990935	molecular_function	splicing factor binding
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
H	0000387	biological_process	spliceosomal snRNP assembly
H	0000389	biological_process	mRNA 3'-splice site recognition
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005684	cellular_component	U2-type spliceosomal complex
H	0005686	cellular_component	U2 snRNP
H	0006396	biological_process	RNA processing
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0016607	cellular_component	nuclear speck
H	0045292	biological_process	mRNA cis splicing, via spliceosome
H	0071004	cellular_component	U2-type prespliceosome
H	0071005	cellular_component	U2-type precatalytic spliceosome
H	0071013	cellular_component	catalytic step 2 spliceosome
H	1903241	biological_process	U2-type prespliceosome assembly
I	0000245	biological_process	spliceosomal complex assembly
I	0000387	biological_process	spliceosomal snRNP assembly
I	0000389	biological_process	mRNA 3'-splice site recognition
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0003676	molecular_function	nucleic acid binding
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0005684	cellular_component	U2-type spliceosomal complex
I	0005686	cellular_component	U2 snRNP
I	0006397	biological_process	mRNA processing
I	0008270	molecular_function	zinc ion binding
I	0008380	biological_process	RNA splicing
I	0010976	biological_process	positive regulation of neuron projection development
I	0016607	cellular_component	nuclear speck
I	0046872	molecular_function	metal ion binding
I	0071004	cellular_component	U2-type prespliceosome
I	0071005	cellular_component	U2-type precatalytic spliceosome
I	0071013	cellular_component	catalytic step 2 spliceosome
I	1903241	biological_process	U2-type prespliceosome assembly
J	0000375	biological_process	RNA splicing, via transesterification reactions
J	0000387	biological_process	spliceosomal snRNP assembly
J	0000389	biological_process	mRNA 3'-splice site recognition
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003676	molecular_function	nucleic acid binding
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005681	cellular_component	spliceosomal complex
J	0005684	cellular_component	U2-type spliceosomal complex
J	0005686	cellular_component	U2 snRNP
J	0006397	biological_process	mRNA processing
J	0008270	molecular_function	zinc ion binding
J	0008380	biological_process	RNA splicing
J	0016607	cellular_component	nuclear speck
J	0046872	molecular_function	metal ion binding
J	0071005	cellular_component	U2-type precatalytic spliceosome
J	0071013	cellular_component	catalytic step 2 spliceosome
J	1903241	biological_process	U2-type prespliceosome assembly
K	0000077	biological_process	DNA damage checkpoint signaling
K	0000209	biological_process	protein polyubiquitination
K	0000244	biological_process	spliceosomal tri-snRNP complex assembly
K	0000245	biological_process	spliceosomal complex assembly
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000974	cellular_component	Prp19 complex
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005662	cellular_component	DNA replication factor A complex
K	0005681	cellular_component	spliceosomal complex
K	0005737	cellular_component	cytoplasm
K	0005811	cellular_component	lipid droplet
K	0005819	cellular_component	spindle
K	0006281	biological_process	DNA repair
K	0006303	biological_process	double-strand break repair via nonhomologous end joining
K	0006397	biological_process	mRNA processing
K	0006974	biological_process	DNA damage response
K	0008104	biological_process	intracellular protein localization
K	0008380	biological_process	RNA splicing
K	0010498	biological_process	proteasomal protein catabolic process
K	0016020	cellular_component	membrane
K	0016567	biological_process	protein ubiquitination
K	0016607	cellular_component	nuclear speck
K	0016740	molecular_function	transferase activity
K	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
K	0035861	cellular_component	site of double-strand break
K	0042802	molecular_function	identical protein binding
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0070534	biological_process	protein K63-linked ubiquitination
K	0071006	cellular_component	U2-type catalytic step 1 spliceosome
K	0071007	cellular_component	U2-type catalytic step 2 spliceosome
K	0071013	cellular_component	catalytic step 2 spliceosome
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005684	cellular_component	U2-type spliceosomal complex
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0070274	cellular_component	RES complex
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	1903241	biological_process	U2-type prespliceosome assembly
M	0000077	biological_process	DNA damage checkpoint signaling
M	0000209	biological_process	protein polyubiquitination
M	0000244	biological_process	spliceosomal tri-snRNP complex assembly
M	0000245	biological_process	spliceosomal complex assembly
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000974	cellular_component	Prp19 complex
M	0004842	molecular_function	ubiquitin-protein transferase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005662	cellular_component	DNA replication factor A complex
M	0005681	cellular_component	spliceosomal complex
M	0005737	cellular_component	cytoplasm
M	0005811	cellular_component	lipid droplet
M	0005819	cellular_component	spindle
M	0006281	biological_process	DNA repair
M	0006303	biological_process	double-strand break repair via nonhomologous end joining
M	0006397	biological_process	mRNA processing
M	0006974	biological_process	DNA damage response
M	0008104	biological_process	intracellular protein localization
M	0008380	biological_process	RNA splicing
M	0010498	biological_process	proteasomal protein catabolic process
M	0016020	cellular_component	membrane
M	0016567	biological_process	protein ubiquitination
M	0016607	cellular_component	nuclear speck
M	0016740	molecular_function	transferase activity
M	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
M	0035861	cellular_component	site of double-strand break
M	0042802	molecular_function	identical protein binding
M	0061630	molecular_function	ubiquitin protein ligase activity
M	0070534	biological_process	protein K63-linked ubiquitination
M	0071006	cellular_component	U2-type catalytic step 1 spliceosome
M	0071007	cellular_component	U2-type catalytic step 2 spliceosome
M	0071013	cellular_component	catalytic step 2 spliceosome
N	0000166	molecular_function	nucleotide binding
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0002376	biological_process	immune system process
N	0003676	molecular_function	nucleic acid binding
N	0003723	molecular_function	RNA binding
N	0003724	molecular_function	RNA helicase activity
N	0004386	molecular_function	helicase activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0005737	cellular_component	cytoplasm
N	0006397	biological_process	mRNA processing
N	0008186	molecular_function	ATP-dependent activity, acting on RNA
N	0008380	biological_process	RNA splicing
N	0016787	molecular_function	hydrolase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0038187	molecular_function	pattern recognition receptor activity
N	0043130	molecular_function	ubiquitin binding
N	0045087	biological_process	innate immune response
N	0060090	molecular_function	molecular adaptor activity
N	0071005	cellular_component	U2-type precatalytic spliceosome
N	0140374	biological_process	antiviral innate immune response
N	1990904	cellular_component	ribonucleoprotein complex
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0001650	cellular_component	fibrillar center
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005662	cellular_component	DNA replication factor A complex
O	0005681	cellular_component	spliceosomal complex
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0016607	cellular_component	nuclear speck
O	0031965	cellular_component	nuclear membrane
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
P	0000077	biological_process	DNA damage checkpoint signaling
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000974	cellular_component	Prp19 complex
P	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
P	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
P	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
P	0003677	molecular_function	DNA binding
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005662	cellular_component	DNA replication factor A complex
P	0005681	cellular_component	spliceosomal complex
P	0005737	cellular_component	cytoplasm
P	0006281	biological_process	DNA repair
P	0006351	biological_process	DNA-templated transcription
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006397	biological_process	mRNA processing
P	0006974	biological_process	DNA damage response
P	0008380	biological_process	RNA splicing
P	0016020	cellular_component	membrane
P	0016607	cellular_component	nuclear speck
P	0019904	molecular_function	protein domain specific binding
P	0042802	molecular_function	identical protein binding
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
P	0071987	molecular_function	WD40-repeat domain binding
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0006397	biological_process	mRNA processing
Q	0008380	biological_process	RNA splicing
Q	0016607	cellular_component	nuclear speck
Q	0045292	biological_process	mRNA cis splicing, via spliceosome
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Q	0071013	cellular_component	catalytic step 2 spliceosome
R	0000077	biological_process	DNA damage checkpoint signaling
R	0000209	biological_process	protein polyubiquitination
R	0000244	biological_process	spliceosomal tri-snRNP complex assembly
R	0000245	biological_process	spliceosomal complex assembly
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0000974	cellular_component	Prp19 complex
R	0004842	molecular_function	ubiquitin-protein transferase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005662	cellular_component	DNA replication factor A complex
R	0005681	cellular_component	spliceosomal complex
R	0005737	cellular_component	cytoplasm
R	0005811	cellular_component	lipid droplet
R	0005819	cellular_component	spindle
R	0006281	biological_process	DNA repair
R	0006303	biological_process	double-strand break repair via nonhomologous end joining
R	0006397	biological_process	mRNA processing
R	0006974	biological_process	DNA damage response
R	0008104	biological_process	intracellular protein localization
R	0008380	biological_process	RNA splicing
R	0010498	biological_process	proteasomal protein catabolic process
R	0016020	cellular_component	membrane
R	0016567	biological_process	protein ubiquitination
R	0016607	cellular_component	nuclear speck
R	0016740	molecular_function	transferase activity
R	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
R	0035861	cellular_component	site of double-strand break
R	0042802	molecular_function	identical protein binding
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0070534	biological_process	protein K63-linked ubiquitination
R	0071006	cellular_component	U2-type catalytic step 1 spliceosome
R	0071007	cellular_component	U2-type catalytic step 2 spliceosome
R	0071013	cellular_component	catalytic step 2 spliceosome
S	0000375	biological_process	RNA splicing, via transesterification reactions
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000974	cellular_component	Prp19 complex
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005662	cellular_component	DNA replication factor A complex
S	0005681	cellular_component	spliceosomal complex
S	0005730	cellular_component	nucleolus
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0016607	cellular_component	nuclear speck
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000785	cellular_component	chromatin
T	0003713	molecular_function	transcription coactivator activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005681	cellular_component	spliceosomal complex
T	0006351	biological_process	DNA-templated transcription
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0016922	molecular_function	nuclear receptor binding
T	0045893	biological_process	positive regulation of DNA-templated transcription
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0000974	cellular_component	Prp19 complex
U	0003676	molecular_function	nucleic acid binding
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0005737	cellular_component	cytoplasm
U	0006397	biological_process	mRNA processing
U	0008270	molecular_function	zinc ion binding
U	0008380	biological_process	RNA splicing
U	0017070	molecular_function	U6 snRNA binding
U	0033120	biological_process	positive regulation of RNA splicing
U	0036002	molecular_function	pre-mRNA binding
U	0042307	biological_process	positive regulation of protein import into nucleus
U	0045292	biological_process	mRNA cis splicing, via spliceosome
U	0046827	biological_process	positive regulation of protein export from nucleus
U	0046872	molecular_function	metal ion binding
U	0048306	molecular_function	calcium-dependent protein binding
U	0071006	cellular_component	U2-type catalytic step 1 spliceosome
U	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
U	0071466	biological_process	cellular response to xenobiotic stimulus
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0000413	biological_process	protein peptidyl-prolyl isomerization
V	0003676	molecular_function	nucleic acid binding
V	0003723	molecular_function	RNA binding
V	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005829	cellular_component	cytosol
V	0016853	molecular_function	isomerase activity
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005681	cellular_component	spliceosomal complex
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0016607	cellular_component	nuclear speck
W	0048024	biological_process	regulation of mRNA splicing, via spliceosome
W	0071005	cellular_component	U2-type precatalytic spliceosome
W	0071006	cellular_component	U2-type catalytic step 1 spliceosome
W	0071007	cellular_component	U2-type catalytic step 2 spliceosome
W	0071013	cellular_component	catalytic step 2 spliceosome
X	0000245	biological_process	spliceosomal complex assembly
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0000974	cellular_component	Prp19 complex
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0006396	biological_process	RNA processing
X	0006397	biological_process	mRNA processing
X	0008380	biological_process	RNA splicing
X	0016607	cellular_component	nuclear speck
X	0071007	cellular_component	U2-type catalytic step 2 spliceosome
X	0071013	cellular_component	catalytic step 2 spliceosome
X	0071014	cellular_component	post-mRNA release spliceosomal complex
Y	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0003713	molecular_function	transcription coactivator activity
Y	0003714	molecular_function	transcription corepressor activity
Y	0003723	molecular_function	RNA binding
Y	0005112	molecular_function	Notch binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005681	cellular_component	spliceosomal complex
Y	0006351	biological_process	DNA-templated transcription
Y	0006357	biological_process	regulation of transcription by RNA polymerase II
Y	0006397	biological_process	mRNA processing
Y	0008024	cellular_component	cyclin/CDK positive transcription elongation factor complex
Y	0008380	biological_process	RNA splicing
Y	0016363	cellular_component	nuclear matrix
Y	0016607	cellular_component	nuclear speck
Y	0016922	molecular_function	nuclear receptor binding
Y	0019899	molecular_function	enzyme binding
Y	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
Y	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Y	0042809	molecular_function	nuclear vitamin D receptor binding
Y	0042974	molecular_function	nuclear retinoic acid receptor binding
Y	0043923	biological_process	host-mediated activation of viral transcription
Y	0045892	biological_process	negative regulation of DNA-templated transcription
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0046332	molecular_function	SMAD binding
Y	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
Y	0048255	biological_process	mRNA stabilization
Y	0048384	biological_process	retinoic acid receptor signaling pathway
Y	0048385	biological_process	regulation of retinoic acid receptor signaling pathway
Y	0050681	molecular_function	nuclear androgen receptor binding
Y	0050769	biological_process	positive regulation of neurogenesis
Y	0070562	biological_process	regulation of vitamin D receptor signaling pathway
Y	0070564	biological_process	positive regulation of vitamin D receptor signaling pathway
Y	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Y	0071013	cellular_component	catalytic step 2 spliceosome
Y	0071300	biological_process	cellular response to retinoic acid
Z	0000398	biological_process	mRNA splicing, via spliceosome
Z	0004842	molecular_function	ubiquitin-protein transferase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005681	cellular_component	spliceosomal complex
Z	0005684	cellular_component	U2-type spliceosomal complex
Z	0006281	biological_process	DNA repair
Z	0006397	biological_process	mRNA processing
Z	0006974	biological_process	DNA damage response
Z	0008270	molecular_function	zinc ion binding
Z	0008380	biological_process	RNA splicing
Z	0016567	biological_process	protein ubiquitination
Z	0016607	cellular_component	nuclear speck
Z	0016740	molecular_function	transferase activity
Z	0046872	molecular_function	metal ion binding
Z	0061630	molecular_function	ubiquitin protein ligase activity
Z	0070100	biological_process	negative regulation of chemokine-mediated signaling pathway
Z	0071005	cellular_component	U2-type precatalytic spliceosome
a	0000244	biological_process	spliceosomal tri-snRNP complex assembly
a	0000375	biological_process	RNA splicing, via transesterification reactions
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0006397	biological_process	mRNA processing
a	0008233	molecular_function	peptidase activity
a	0008237	molecular_function	metallopeptidase activity
a	0008380	biological_process	RNA splicing
a	0016020	cellular_component	membrane
a	0016607	cellular_component	nuclear speck
a	0017070	molecular_function	U6 snRNA binding
a	0030532	cellular_component	small nuclear ribonucleoprotein complex
a	0030619	molecular_function	U1 snRNA binding
a	0030620	molecular_function	U2 snRNA binding
a	0030623	molecular_function	U5 snRNA binding
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
a	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
a	0071005	cellular_component	U2-type precatalytic spliceosome
a	0071006	cellular_component	U2-type catalytic step 1 spliceosome
a	0071007	cellular_component	U2-type catalytic step 2 spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	0071222	biological_process	cellular response to lipopolysaccharide
a	0071356	biological_process	cellular response to tumor necrosis factor
a	0097157	molecular_function	pre-mRNA intronic binding
a	0140492	molecular_function	metal-dependent deubiquitinase activity
a	1990904	cellular_component	ribonucleoprotein complex
b	0000166	molecular_function	nucleotide binding
b	0000244	biological_process	spliceosomal tri-snRNP complex assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0003924	molecular_function	GTPase activity
b	0005515	molecular_function	protein binding
b	0005525	molecular_function	GTP binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005829	cellular_component	cytosol
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0015030	cellular_component	Cajal body
b	0016020	cellular_component	membrane
b	0016607	cellular_component	nuclear speck
b	0030623	molecular_function	U5 snRNA binding
b	0042220	biological_process	response to cocaine
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0071466	biological_process	cellular response to xenobiotic stimulus
c	0000166	molecular_function	nucleotide binding
c	0000244	biological_process	spliceosomal tri-snRNP complex assembly
c	0000354	biological_process	cis assembly of pre-catalytic spliceosome
c	0000387	biological_process	spliceosomal snRNP assembly
c	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0001649	biological_process	osteoblast differentiation
c	0003676	molecular_function	nucleic acid binding
c	0003723	molecular_function	RNA binding
c	0003724	molecular_function	RNA helicase activity
c	0004386	molecular_function	helicase activity
c	0005515	molecular_function	protein binding
c	0005524	molecular_function	ATP binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005681	cellular_component	spliceosomal complex
c	0005682	cellular_component	U5 snRNP
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0016020	cellular_component	membrane
c	0016787	molecular_function	hydrolase activity
c	0016887	molecular_function	ATP hydrolysis activity
c	0030532	cellular_component	small nuclear ribonucleoprotein complex
c	0042802	molecular_function	identical protein binding
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
c	0071005	cellular_component	U2-type precatalytic spliceosome
c	0071006	cellular_component	U2-type catalytic step 1 spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
h	0000244	biological_process	spliceosomal tri-snRNP complex assembly
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005683	cellular_component	U7 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005829	cellular_component	cytosol
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0022618	biological_process	protein-RNA complex assembly
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034709	cellular_component	methylosome
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0071045	biological_process	nuclear histone mRNA catabolic process
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990904	cellular_component	ribonucleoprotein complex
i	0000244	biological_process	spliceosomal tri-snRNP complex assembly
i	0000245	biological_process	spliceosomal complex assembly
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005683	cellular_component	U7 snRNP
i	0005684	cellular_component	U2-type spliceosomal complex
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005689	cellular_component	U12-type spliceosomal complex
i	0005697	cellular_component	telomerase holoenzyme complex
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034709	cellular_component	methylosome
i	0034715	cellular_component	pICln-Sm protein complex
i	0034719	cellular_component	SMN-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
i	0071005	cellular_component	U2-type precatalytic spliceosome
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071011	cellular_component	precatalytic spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0071045	biological_process	nuclear histone mRNA catabolic process
i	1903241	biological_process	U2-type prespliceosome assembly
i	1990904	cellular_component	ribonucleoprotein complex
j	0000243	cellular_component	commitment complex
j	0000244	biological_process	spliceosomal tri-snRNP complex assembly
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005683	cellular_component	U7 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005697	cellular_component	telomerase holoenzyme complex
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006396	biological_process	RNA processing
j	0006397	biological_process	mRNA processing
j	0006479	biological_process	protein methylation
j	0008380	biological_process	RNA splicing
j	0016604	cellular_component	nuclear body
j	0019899	molecular_function	enzyme binding
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
j	0070034	molecular_function	telomerase RNA binding
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0071045	biological_process	nuclear histone mRNA catabolic process
j	0071208	molecular_function	histone pre-mRNA DCP binding
j	0071209	molecular_function	U7 snRNA binding
j	0097526	cellular_component	spliceosomal tri-snRNP complex
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0000243	cellular_component	commitment complex
k	0000244	biological_process	spliceosomal tri-snRNP complex assembly
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006396	biological_process	RNA processing
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034709	cellular_component	methylosome
k	0034715	cellular_component	pICln-Sm protein complex
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0097526	cellular_component	spliceosomal tri-snRNP complex
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990446	molecular_function	U1 snRNP binding
k	1990904	cellular_component	ribonucleoprotein complex
l	0000244	biological_process	spliceosomal tri-snRNP complex assembly
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005684	cellular_component	U2-type spliceosomal complex
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005689	cellular_component	U12-type spliceosomal complex
l	0005829	cellular_component	cytosol
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034709	cellular_component	methylosome
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
l	0070062	cellular_component	extracellular exosome
l	0071005	cellular_component	U2-type precatalytic spliceosome
l	0071007	cellular_component	U2-type catalytic step 2 spliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0097525	cellular_component	spliceosomal snRNP complex
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
m	0000244	biological_process	spliceosomal tri-snRNP complex assembly
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005683	cellular_component	U7 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034709	cellular_component	methylosome
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0043186	cellular_component	P granule
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
m	0071004	cellular_component	U2-type prespliceosome
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071011	cellular_component	precatalytic spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0071045	biological_process	nuclear histone mRNA catabolic process
m	0097526	cellular_component	spliceosomal tri-snRNP complex
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
n	0000244	biological_process	spliceosomal tri-snRNP complex assembly
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005683	cellular_component	U7 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005697	cellular_component	telomerase holoenzyme complex
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0006479	biological_process	protein methylation
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034709	cellular_component	methylosome
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
n	0070034	molecular_function	telomerase RNA binding
n	0070990	molecular_function	snRNP binding
n	0071004	cellular_component	U2-type prespliceosome
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0071045	biological_process	nuclear histone mRNA catabolic process
n	0071204	cellular_component	histone pre-mRNA 3'end processing complex
n	0071208	molecular_function	histone pre-mRNA DCP binding
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990446	molecular_function	U1 snRNP binding
n	1990447	molecular_function	U2 snRNP binding
n	1990904	cellular_component	ribonucleoprotein complex
o	0000244	biological_process	spliceosomal tri-snRNP complex assembly
o	0000375	biological_process	RNA splicing, via transesterification reactions
o	0000387	biological_process	spliceosomal snRNP assembly
o	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005681	cellular_component	spliceosomal complex
o	0005682	cellular_component	U5 snRNP
o	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
o	0006396	biological_process	RNA processing
o	0006397	biological_process	mRNA processing
o	0008380	biological_process	RNA splicing
o	0016607	cellular_component	nuclear speck
o	0071007	cellular_component	U2-type catalytic step 2 spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0000413	biological_process	protein peptidyl-prolyl isomerization
p	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005730	cellular_component	nucleolus
p	0006397	biological_process	mRNA processing
p	0006457	biological_process	protein folding
p	0008380	biological_process	RNA splicing
p	0016853	molecular_function	isomerase activity
p	0071007	cellular_component	U2-type catalytic step 2 spliceosome
p	0071013	cellular_component	catalytic step 2 spliceosome
p	0097718	molecular_function	disordered domain specific binding
p	1990403	biological_process	embryonic brain development
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0003723	molecular_function	RNA binding
q	0003729	molecular_function	mRNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0006397	biological_process	mRNA processing
q	0008380	biological_process	RNA splicing
q	0015030	cellular_component	Cajal body
q	0016607	cellular_component	nuclear speck
q	0070742	molecular_function	C2H2 zinc finger domain binding
q	0071005	cellular_component	U2-type precatalytic spliceosome
q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
q	0071013	cellular_component	catalytic step 2 spliceosome
r	0000387	biological_process	spliceosomal snRNP assembly
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0003723	molecular_function	RNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005681	cellular_component	spliceosomal complex
r	0005684	cellular_component	U2-type spliceosomal complex
r	0005686	cellular_component	U2 snRNP
r	0006397	biological_process	mRNA processing
r	0007283	biological_process	spermatogenesis
r	0008380	biological_process	RNA splicing
r	0016604	cellular_component	nuclear body
r	0016607	cellular_component	nuclear speck
r	0030532	cellular_component	small nuclear ribonucleoprotein complex
r	0030620	molecular_function	U2 snRNA binding
r	0071005	cellular_component	U2-type precatalytic spliceosome
r	0071007	cellular_component	U2-type catalytic step 2 spliceosome
r	0071013	cellular_component	catalytic step 2 spliceosome
r	1903241	biological_process	U2-type prespliceosome assembly
r	1990904	cellular_component	ribonucleoprotein complex
s	0000387	biological_process	spliceosomal snRNP assembly
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0003676	molecular_function	nucleic acid binding
s	0003723	molecular_function	RNA binding
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005681	cellular_component	spliceosomal complex
s	0005684	cellular_component	U2-type spliceosomal complex
s	0005685	cellular_component	U1 snRNP
s	0005686	cellular_component	U2 snRNP
s	0006397	biological_process	mRNA processing
s	0008380	biological_process	RNA splicing
s	0016607	cellular_component	nuclear speck
s	0030619	molecular_function	U1 snRNA binding
s	0071005	cellular_component	U2-type precatalytic spliceosome
s	0071007	cellular_component	U2-type catalytic step 2 spliceosome
s	0071013	cellular_component	catalytic step 2 spliceosome
s	0097525	cellular_component	spliceosomal snRNP complex
s	1903241	biological_process	U2-type prespliceosome assembly
s	1990904	cellular_component	ribonucleoprotein complex
t	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
t	0000389	biological_process	mRNA 3'-splice site recognition
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0000974	cellular_component	Prp19 complex
t	0003723	molecular_function	RNA binding
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005681	cellular_component	spliceosomal complex
t	0006397	biological_process	mRNA processing
t	0008380	biological_process	RNA splicing
t	0016607	cellular_component	nuclear speck
t	0071006	cellular_component	U2-type catalytic step 1 spliceosome
t	0071013	cellular_component	catalytic step 2 spliceosome
t	0071014	cellular_component	post-mRNA release spliceosomal complex
t	0071020	cellular_component	post-spliceosomal complex
u	0000209	biological_process	protein polyubiquitination
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0000413	biological_process	protein peptidyl-prolyl isomerization
u	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
u	0004842	molecular_function	ubiquitin-protein transferase activity
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005681	cellular_component	spliceosomal complex
u	0005737	cellular_component	cytoplasm
u	0005796	cellular_component	Golgi lumen
u	0005886	cellular_component	plasma membrane
u	0006397	biological_process	mRNA processing
u	0006457	biological_process	protein folding
u	0008380	biological_process	RNA splicing
u	0016567	biological_process	protein ubiquitination
u	0016740	molecular_function	transferase activity
u	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
u	0061630	molecular_function	ubiquitin protein ligase activity
u	0071013	cellular_component	catalytic step 2 spliceosome
u	0072659	biological_process	protein localization to plasma membrane
v	0000077	biological_process	DNA damage checkpoint signaling
v	0000209	biological_process	protein polyubiquitination
v	0000244	biological_process	spliceosomal tri-snRNP complex assembly
v	0000245	biological_process	spliceosomal complex assembly
v	0000398	biological_process	mRNA splicing, via spliceosome
v	0000974	cellular_component	Prp19 complex
v	0004842	molecular_function	ubiquitin-protein transferase activity
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005662	cellular_component	DNA replication factor A complex
v	0005681	cellular_component	spliceosomal complex
v	0005737	cellular_component	cytoplasm
v	0005811	cellular_component	lipid droplet
v	0005819	cellular_component	spindle
v	0006281	biological_process	DNA repair
v	0006303	biological_process	double-strand break repair via nonhomologous end joining
v	0006397	biological_process	mRNA processing
v	0006974	biological_process	DNA damage response
v	0008104	biological_process	intracellular protein localization
v	0008380	biological_process	RNA splicing
v	0010498	biological_process	proteasomal protein catabolic process
v	0016020	cellular_component	membrane
v	0016567	biological_process	protein ubiquitination
v	0016607	cellular_component	nuclear speck
v	0016740	molecular_function	transferase activity
v	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
v	0035861	cellular_component	site of double-strand break
v	0042802	molecular_function	identical protein binding
v	0061630	molecular_function	ubiquitin protein ligase activity
v	0070534	biological_process	protein K63-linked ubiquitination
v	0071006	cellular_component	U2-type catalytic step 1 spliceosome
v	0071007	cellular_component	U2-type catalytic step 2 spliceosome
v	0071013	cellular_component	catalytic step 2 spliceosome
w	0000398	biological_process	mRNA splicing, via spliceosome
w	0000413	biological_process	protein peptidyl-prolyl isomerization
w	0003676	molecular_function	nucleic acid binding
w	0003723	molecular_function	RNA binding
w	0003729	molecular_function	mRNA binding
w	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
w	0005515	molecular_function	protein binding
w	0005576	cellular_component	extracellular region
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005681	cellular_component	spliceosomal complex
w	0005737	cellular_component	cytoplasm
w	0006355	biological_process	regulation of DNA-templated transcription
w	0006397	biological_process	mRNA processing
w	0006457	biological_process	protein folding
w	0008143	molecular_function	poly(A) binding
w	0008380	biological_process	RNA splicing
w	0016018	molecular_function	cyclosporin A binding
w	0016607	cellular_component	nuclear speck
w	0016853	molecular_function	isomerase activity
w	0032991	cellular_component	protein-containing complex
w	0034774	cellular_component	secretory granule lumen
w	0045070	biological_process	positive regulation of viral genome replication
w	0071007	cellular_component	U2-type catalytic step 2 spliceosome
w	0071013	cellular_component	catalytic step 2 spliceosome
w	1904813	cellular_component	ficolin-1-rich granule lumen
x	0000398	biological_process	mRNA splicing, via spliceosome
x	0003723	molecular_function	RNA binding
x	0003729	molecular_function	mRNA binding
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005654	cellular_component	nucleoplasm
x	0005681	cellular_component	spliceosomal complex
x	0006397	biological_process	mRNA processing
x	0008380	biological_process	RNA splicing
x	0016607	cellular_component	nuclear speck
x	0071007	cellular_component	U2-type catalytic step 2 spliceosome
x	0071013	cellular_component	catalytic step 2 spliceosome
x	1990403	biological_process	embryonic brain development
y	0000166	molecular_function	nucleotide binding
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0003723	molecular_function	RNA binding
y	0003724	molecular_function	RNA helicase activity
y	0003727	molecular_function	single-stranded RNA binding
y	0003729	molecular_function	mRNA binding
y	0004386	molecular_function	helicase activity
y	0005515	molecular_function	protein binding
y	0005524	molecular_function	ATP binding
y	0005634	cellular_component	nucleus
y	0005654	cellular_component	nucleoplasm
y	0005681	cellular_component	spliceosomal complex
y	0006397	biological_process	mRNA processing
y	0008380	biological_process	RNA splicing
y	0016020	cellular_component	membrane
y	0016787	molecular_function	hydrolase activity
y	0016887	molecular_function	ATP hydrolysis activity
y	0034458	molecular_function	3'-5' RNA helicase activity
y	0071007	cellular_component	U2-type catalytic step 2 spliceosome
y	0071013	cellular_component	catalytic step 2 spliceosome
z	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
z	0000398	biological_process	mRNA splicing, via spliceosome
z	0000974	cellular_component	Prp19 complex
z	0005515	molecular_function	protein binding
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005681	cellular_component	spliceosomal complex
z	0006281	biological_process	DNA repair
z	0006283	biological_process	transcription-coupled nucleotide-excision repair
z	0006351	biological_process	DNA-templated transcription
z	0006396	biological_process	RNA processing
z	0006397	biological_process	mRNA processing
z	0006974	biological_process	DNA damage response
z	0008380	biological_process	RNA splicing
z	0016020	cellular_component	membrane
z	0021987	biological_process	cerebral cortex development
z	0071007	cellular_component	U2-type catalytic step 2 spliceosome
z	0071013	cellular_component	catalytic step 2 spliceosome
z	0071014	cellular_component	post-mRNA release spliceosomal complex

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngTkFHRIIkdFMiQGG

Chain	Residue	Details
p	TYR48-GLY65
u	TYR316-GLY333
w	PHE184-GLY201

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
A	PHE287-HIS293

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CrHyFCesCA

Chain	Residue	Details
Z	CYS277-ALA286

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAadDsSVKLWDL

Chain	Residue	Details
v	LEU407-LEU421
x	LEU304-VAL318
o	LEU81-VAL95
o	LEU124-SER138
o	VAL167-ILE181
o	ILE208-LEU222
o	ILE300-THR314
O	LEU303-VAL317
O	ILE345-LEU359

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SvVMVDEAHE

Chain	Residue	Details
N	SER515-GLU524

---

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP

Chain	Residue	Details
T	LEU100-PRO122

---

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CtHCGCRGCS

Chain	Residue	Details
T	CYS134-SER143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	300
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	79
Details	Region: {"description":"Sufficient for interaction with CLNS1A","evidences":[{"source":"PubMed","id":"11747828","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	37
Details	Region: {"description":"Interaction with PHF5A, SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	21
Details	Region: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	23
Details	Region: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Site: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	13
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	77
Details	Region: {"description":"Interaction with SF3B1 and SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	5
Details	Site: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	14
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	34
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	37
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	34
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	38
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	38
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	38
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	38
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	38
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	38
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	38
Details	Repeat: {"description":"HEAT 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	39
Details	Region: {"description":"Interaction with SF3B14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Region: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B3 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Site: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	4
Details	Site: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	3
Details	Region: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28541300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SYB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT9; alternate","evidences":[{"source":"PubMed","id":"25737013","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	15
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Site: {"description":"Critical for binding to SF3A3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	81
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q62203","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	31
Details	Zinc finger: {"description":"Matrin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	4
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"21349847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	11
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	19
Details	Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	4
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2010","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	164
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	173
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	118
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	117
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	121
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	117
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	118
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	118
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	69
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	51
Details	Domain: {"description":"HTH myb-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI60
Number of Residues	45
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI61
Number of Residues	94
Details	Region: {"description":"Interaction with PLRG1","evidences":[{"source":"PubMed","id":"11544257","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI62
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18583928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI63
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI64
Number of Residues	10
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI65
Number of Residues	8
Details	Region: {"description":"Interaction with AR","evidences":[{"source":"PubMed","id":"28076346","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI66
Number of Residues	8
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI67
Number of Residues	55
Details	Zinc finger: {"description":"C3H1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00723","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI68
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI69
Number of Residues	183
Details	Domain: {"description":"MIF4G","evidences":[{"source":"PROSITE-ProRule","id":"PRU00698","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI70
Number of Residues	116
Details	Domain: {"description":"MI","evidences":[{"source":"PROSITE-ProRule","id":"PRU00698","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI71
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI72
Number of Residues	32
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI73
Number of Residues	32
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI74
Number of Residues	31
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI75
Number of Residues	31
Details	Repeat: {"description":"HAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI76
Number of Residues	67
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI77
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI78
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI79
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI80
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI81
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI82
Number of Residues	38
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI83
Number of Residues	131
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI84
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI85
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI86
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI87
Number of Residues	1
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI88
Number of Residues	282
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI89
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI90
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI91
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI92
Number of Residues	183
Details	Domain: {"description":"Helicase ATP-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI93
Number of Residues	237
Details	Domain: {"description":"Helicase C-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI94
Number of Residues	305
Details	Domain: {"description":"SEC63 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI95
Number of Residues	175
Details	Domain: {"description":"Helicase ATP-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI96
Number of Residues	208
Details	Domain: {"description":"Helicase C-terminal 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI97
Number of Residues	312
Details	Domain: {"description":"SEC63 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI98
Number of Residues	3
Details	Motif: {"description":"DEIH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI99
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI100
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23045696","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F93","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI101
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"F1LNJ2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI102
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q6P4T2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI103
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI104
Number of Residues	309
Details	Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI105
Number of Residues	23
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16595688","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI106
Number of Residues	32
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI107
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Heiserich L.","Boulahbel H.","Gottlieb E."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI108
Number of Residues	21
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI109
Number of Residues	21
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI110
Number of Residues	21
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI111
Number of Residues	21
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI112
Number of Residues	38
Details	Domain: {"description":"LRRCT"}

Chain

Residue

Details

---

site_id	SWS_FT_FI113
Number of Residues	79
Details	Domain: {"description":"RRM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI114
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25599396","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PJ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI115
Number of Residues	32
Details	Repeat: {"description":"HAT 2","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI116
Number of Residues	32
Details	Repeat: {"description":"HAT 3","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI117
Number of Residues	34
Details	Repeat: {"description":"HAT 4","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI118
Number of Residues	32
Details	Repeat: {"description":"HAT 5","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI119
Number of Residues	33
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI120
Number of Residues	35
Details	Repeat: {"description":"HAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI121
Number of Residues	38
Details	Repeat: {"description":"HAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI122
Number of Residues	32
Details	Repeat: {"description":"HAT 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI123
Number of Residues	34
Details	Repeat: {"description":"HAT 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI124
Number of Residues	34
Details	Repeat: {"description":"HAT 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI125
Number of Residues	34
Details	Repeat: {"description":"HAT 13"}

Chain

Residue

Details

---

site_id	SWS_FT_FI126
Number of Residues	34
Details	Repeat: {"description":"HAT 14"}

Chain

Residue

Details

---