4PJ3

Structural insight into the function and evolution of the spliceosomal helicase Aquarius, Structure of Aquarius in complex with AMPPNP

Summary for 4PJ3

• Entry DOI: 10.2210/pdb4pj3/pdb
• Related: 4PJ4
• Descriptor: Intron-binding protein aquarius, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: rna helicase, pre-mrna splicing, rna binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : O60306
• Total number of polymer chains: 1
• Total formula weight: 173110.18

Authors

De, I.,Bessonov, S.,Hofele, R.,dos Santos, K.F.,Will, C.L.,Urlaub, H.,Luhrmann, R.,Pena, V. (deposition date: 2014-05-11, release date: 2015-01-21, Last modification date: 2023-12-27)

• Primary citation: De, I.,Bessonov, S.,Hofele, R.,Dos Santos, K.,Will, C.L.,Urlaub, H.,Luhrmann, R.,Pena, V.; The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.; Nat.Struct.Mol.Biol., 22:138-144, 2015; PubMed: 25599396; DOI: 10.1038/nsmb.2951

Experimental method

X-RAY DIFFRACTION (2.3 Å)