1E7K
 
 | | Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment | | Descriptor: | 15.5 KD RNA BINDING PROTEIN, RNA (5'-R(*GP*CP*CP*AP*AP*UP*GP*AP*GP*GP*UP*UP*UP* AP*UP*CP*CP*GP*AP*GP*G*C(-3') | | Authors: | Vidovic, I, Nottrott, S, Harthmuth, K, Luhrmann, R, Ficner, R. | | Deposit date: | 2000-08-29 | | Release date: | 2001-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal Structure of the Spliceosomal 15.5Kd Protein Bound to a U4 Snrna Fragment
Mol.Cell, 6, 2000
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3JCR
 | | 3D structure determination of the human*U4/U6.U5* tri-snRNP complex | | Descriptor: | LSm2, LSm3, LSm4, ... | | Authors: | Agafonov, D.E, Kastner, B, Dybkov, O, Hofele, R.V, Liu, W.T, Urlaub, H, Luhrmann, R, Stark, H. | | Deposit date: | 2016-01-21 | | Release date: | 2016-03-09 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science, 351, 2016
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4PJ3
 | | Structural insight into the function and evolution of the spliceosomal helicase Aquarius, Structure of Aquarius in complex with AMPPNP | | Descriptor: | Intron-binding protein aquarius, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | De, I, Bessonov, S, Hofele, R, dos Santos, K.F, Will, C.L, Urlaub, H, Luhrmann, R, Pena, V. | | Deposit date: | 2014-05-11 | | Release date: | 2015-01-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.
Nat.Struct.Mol.Biol., 22, 2015
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1SYX
 | | The crystal structure of a binary U5 snRNP complex | | Descriptor: | CD2 antigen cytoplasmic tail-binding protein 2, Spliceosomal U5 snRNP-specific 15 kDa protein | | Authors: | Nielsen, T.K, Liu, S, Luhrmann, R, Ficner, R. | | Deposit date: | 2004-04-02 | | Release date: | 2005-10-18 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.345 Å) | | Cite: | Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2).
J.Mol.Biol., 369, 2007
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5IFE
 | | Crystal structure of the human SF3b core complex | | Descriptor: | PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... | | Authors: | Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V. | | Deposit date: | 2016-02-25 | | Release date: | 2016-10-26 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Mol.Cell, 64, 2016
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3SIU
 | | Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, monomeric form | | Descriptor: | NHP2-like protein 1, SULFATE ION, U4/U6 small nuclear ribonucleoprotein Prp31, ... | | Authors: | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | | Deposit date: | 2011-06-20 | | Release date: | 2011-08-10 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.626 Å) | | Cite: | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31.
Rna, 17, 2011
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3SIV
 | | Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form | | Descriptor: | NHP2-like protein 1, U4/U6 small nuclear ribonucleoprotein Prp31, U4atac snRNA | | Authors: | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | | Deposit date: | 2011-06-20 | | Release date: | 2011-08-10 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.304 Å) | | Cite: | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31.
Rna, 17, 2011
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2MKC
 | | Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex | | Descriptor: | Pre-mRNA leakage protein 1, Pre-mRNA-splicing factor CWC26, U2 snRNP component IST3 | | Authors: | Wysoczanski, P, Schneider, C, Xiang, S, Munari, F, Trowitzsch, S, Wahl, M.C, Luhrmann, R, Becker, S, Zweckstetter, M. | | Deposit date: | 2014-02-04 | | Release date: | 2014-09-03 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex.
Nat.Struct.Mol.Biol., 21, 2014
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5D0U
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3TP2
 | | Crystal Structure of the Splicing Factor Cwc2 from yeast | | Descriptor: | Pre-mRNA-splicing factor CWC2, SODIUM ION, ZINC ION | | Authors: | Schmitzova, J. | | Deposit date: | 2011-09-07 | | Release date: | 2012-03-14 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein.
Embo J., 31, 2012
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1B34
 | | CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN | | Descriptor: | PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1), PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2) | | Authors: | Walke, S, Young, R.J, Kambach, C, Avis, J.M, De La Fortelle, E, Li, J, Nagai, K. | | Deposit date: | 1998-12-17 | | Release date: | 2000-01-13 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
Cell(Cambridge,Mass.), 96, 1999
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6Y53
 | | human 17S U2 snRNP low resolution part | | Descriptor: | HIV Tat-specific factor 1, Probable ATP-dependent RNA helicase DDX46, Small nuclear ribonucleoprotein E, ... | | Authors: | Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H. | | Deposit date: | 2020-02-24 | | Release date: | 2020-06-17 | | Last modified: | 2020-07-22 | | Method: | ELECTRON MICROSCOPY (7.1 Å) | | Cite: | Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
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6Y5Q
 | | human 17S U2 snRNP | | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... | | Authors: | Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H. | | Deposit date: | 2020-02-25 | | Release date: | 2020-06-17 | | Last modified: | 2020-07-22 | | Method: | ELECTRON MICROSCOPY (7.1 Å) | | Cite: | Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
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6Y50
 | | 5'domain of human 17S U2 snRNP | | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... | | Authors: | Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H. | | Deposit date: | 2020-02-24 | | Release date: | 2020-07-01 | | Last modified: | 2020-07-22 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Molecular architecture of the human 17S U2 snRNP.
Nature, 583, 2020
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1QGV
 | | HUMAN SPLICEOSOMAL PROTEIN U5-15KD | | Descriptor: | SPLICEOSOMAL PROTEIN U5-15KD | | Authors: | Reuter, K, Nottrott, S, Fabrizio, P, Luehrmann, R, Ficner, R. | | Deposit date: | 1999-05-06 | | Release date: | 1999-12-12 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein.
J.Mol.Biol., 294, 1999
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4NHO
 | | Structure of the spliceosomal DEAD-box protein Prp28 | | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, GLYCEROL, MERCURY (II) ION, ... | | Authors: | Moehlmann, S, Neumann, P, Ficner, R. | | Deposit date: | 2013-11-05 | | Release date: | 2014-06-18 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28.
Acta Crystallogr.,Sect.D, 70, 2014
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6SLO
 | | Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine | | Descriptor: | 2-[4-[3-(8-chloranyl-2,3-dimethoxy-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol, MAGNESIUM ION, Thioredoxin,Poly(U)-binding-splicing factor PUF60 | | Authors: | Jagtap, P.K.A, Kubelka, T, Bach, T, Sattler, M. | | Deposit date: | 2019-08-20 | | Release date: | 2020-09-09 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
Nat Commun, 11, 2020
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5DCA
 | | Crystal structure of yeast full length Brr2 in complex with Prp8 Jab1 domain | | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | | Authors: | Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | | Deposit date: | 2015-08-23 | | Release date: | 2015-12-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.
Genes Dev., 29, 2015
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1D3B
 | | CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION | | Descriptor: | CITRIC ACID, GLYCEROL, PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN ASSOCIATED PROTEIN B), ... | | Authors: | Kambach, C, Walke, S, Avis, J.M, De La Fortelle, E, Li, J, Nagai, K. | | Deposit date: | 1998-12-22 | | Release date: | 1999-12-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
Cell(Cambridge,Mass.), 96, 1999
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7OQB
 | | The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | | Descriptor: | ACT1 pre-mRNA (delta-BS-A), Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing ATP-dependent RNA helicase PRP5, ... | | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | | Deposit date: | 2021-06-03 | | Release date: | 2021-08-11 | | Last modified: | 2021-09-22 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
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7OQE
 | | Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ... | | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | | Deposit date: | 2021-06-03 | | Release date: | 2021-08-11 | | Last modified: | 2021-09-29 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
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7OQC
 | | The U1 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A), Pre-mRNA-processing factor 39, ... | | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | | Deposit date: | 2021-06-03 | | Release date: | 2021-08-11 | | Last modified: | 2021-09-29 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
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5HY7
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5O9Z
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6FF7
 | | human Bact spliceosome core structure | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, BUD13 homolog, ... | | Authors: | Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. | | Deposit date: | 2018-01-03 | | Release date: | 2019-03-13 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
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