2MKC

Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex

Summary for 2MKC

DescriptorU2 snRNP component IST3, Pre-mRNA leakage protein 1, Pre-mRNA-splicing factor CWC26 (3 entities in total)
Functional Keywordsspliceosome, snu17p, bud13p, pml1p, heterotrimer, cooperativity, res, splicing, rrm, protein binding, ist3p
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P40565 Q07930 P46947
Total number of polymer chains3
Total molecular weight19838.95
Authors
Wysoczanski, P.,Schneider, C.,Xiang, S.,Munari, F.,Trowitzsch, S.,Wahl, M.C.,Luhrmann, R.,Becker, S.,Zweckstetter, M. (deposition date: 2014-02-04, release date: 2014-09-03, Last modification date: 2014-10-22)
Primary citation
Wysoczanski, P.,Schneider, C.,Xiang, S.,Munari, F.,Trowitzsch, S.,Wahl, M.C.,Luhrmann, R.,Becker, S.,Zweckstetter, M.
Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex.
Nat.Struct.Mol.Biol., 21:911-918, 2014
PubMed: 25218446 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2889
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers40.8%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures