2MKC

Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	U2 snRNP component IST3	polymer	118	13496.0	1	UniProt (P40565) Pfam (PF00076) In PDB	Saccharomyces cerevisiae (Baker's yeast)	Increased sodium tolerance protein 3, U2 snRNP protein SNU17
2	B	Pre-mRNA leakage protein 1	polymer	23	2514.8	1	UniProt (Q07930) In PDB	Saccharomyces cerevisiae (Baker's yeast)
3	C	Pre-mRNA-splicing factor CWC26	polymer	33	3828.2	1	UniProt (P46947) In PDB	Saccharomyces cerevisiae (Baker's yeast)	Bud site selection protein 13, Complexed with CEF1 protein 26, Synthetic lethal with CLF1 protein 7

Sequence modifications

A: 5 - 118 (UniProt: P40565)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag
Met 3	-	expression tag
Gly 4	-	expression tag

B: 202 - 222 (UniProt: Q07930)

PDB	External Database	Details
Gly 200	-	expression tag
Ser 201	-	expression tag

C: 302 - 332 (UniProt: P46947)

PDB	External Database	Details
Gly 300	-	expression tag
Ser 301	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	19839.0
All*	Total formula weight	19839.0

*Water molecules are not included.