7W9M
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![BU of 7w9m by Molmil](/molmil-images/mine/7w9m) | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (S6IV pi helix conformer) | 分子名称: | (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | 登録日 | 2021-12-10 | 公開日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
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6BND
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![BU of 6bnd by Molmil](/molmil-images/mine/6bnd) | Crystal structure of the intrinsic colistin resistance enzyme ICR(Mc) from Moraxella catarrhalis, catalytic domain, Thr315Ala mutant mono-zinc and phosphoethanolamine complex | 分子名称: | PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, POLYETHYLENE GLYCOL (N=34), Phosphoethanolamine transferase, ... | 著者 | Stogios, P.J, Evdokimova, E, Wawrzak, Z, Savchenko, A, Anderson, W.F, Satchell, K.J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-11-16 | 公開日 | 2018-01-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis. ACS Chem. Biol., 13, 2018
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6VX8
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![BU of 6vx8 by Molmil](/molmil-images/mine/6vx8) | bestrophin-2 Ca2+- unbound state 2 (EGTA only) | 分子名称: | Bestrophin, CHLORIDE ION | 著者 | Owji, A.P, Zhao, Q, Ji, C, Kittredge, A, Hopiavuori, A, Fu, Z, Ward, N, Clarke, O, Shen, Y, Zhang, Y, Hendrickson, W.A, Yang, T. | 登録日 | 2020-02-21 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | 主引用文献 | Structural and functional characterization of the bestrophin-2 anion channel. Nat.Struct.Mol.Biol., 27, 2020
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4BNG
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![BU of 4bng by Molmil](/molmil-images/mine/4bng) | Crystal structure of S. aureus FabI in complex with NADP and 5-pentyl- 2-phenoxyphenol | 分子名称: | 5-PENTYL-2-PHENOXYPHENOL, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ... | 著者 | Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C. | 登録日 | 2013-05-15 | 公開日 | 2013-06-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex. Biochemistry, 52, 2013
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6NJ2
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7W9T
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![BU of 7w9t by Molmil](/molmil-images/mine/7w9t) | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV alpha helix conformer) | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P. | 登録日 | 2021-12-10 | 公開日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
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3D65
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![BU of 3d65 by Molmil](/molmil-images/mine/3d65) | Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom, in complex with trypsin | 分子名称: | CALCIUM ION, Cationic trypsin, Textilinin | 著者 | Millers, E.-K.I, Masci, P.P, Lavin, M.F, de Jersey, J, Guddat, L.W. | 登録日 | 2008-05-19 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom, in complex with trypsin To be Published
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6NKB
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6VL0
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![BU of 6vl0 by Molmil](/molmil-images/mine/6vl0) | Crystal Structure of the N-prenyltransferase DabA in Complex with GSPP and Mn2+ | 分子名称: | DabA, GERANYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Chekan, J.R, Noel, J.P, Moore, B.S. | 登録日 | 2020-01-22 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into anN-prenyltransferase. Proc.Natl.Acad.Sci.USA, 117, 2020
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4H6A
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![BU of 4h6a by Molmil](/molmil-images/mine/4h6a) | Crystal Structure of the Allene Oxide Cyclase 2 from Physcomitrella patens | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Allene oxide cyclase, ... | 著者 | Neumann, P, Ficner, R. | 登録日 | 2012-09-19 | 公開日 | 2012-10-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity. Plant Physiol., 160, 2012
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6VO8
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![BU of 6vo8 by Molmil](/molmil-images/mine/6vo8) | X-ray structure of the Cj1427 in the presence of NADH and GDP-D-glycero-D-mannoheptose, an essential NAD-dependent dehydrogenase from Campylobacter jejuni | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Putative sugar-nucleotide epimerase/dehydratease, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{S},5~{S},6~{S})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl] hydrogen phosphate | 著者 | Spencer, K.D, Anderson, T.K, Thoden, J.B, Huddleston, J.P, Raushel, F.M, Holden, H.M. | 登録日 | 2020-01-30 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Analysis of Cj1427, an Essential NAD-Dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides ofCampylobacter jejuni. Biochemistry, 59, 2020
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6NL4
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6NIV
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![BU of 6niv by Molmil](/molmil-images/mine/6niv) | Racemic Phenol-Soluble Modulin Alpha 3 Peptide | 分子名称: | Phenol-soluble modulin PSM-alpha-3 | 著者 | Yao, Z, Cary, B.P, Bingman, C.A, Wang, C, Kreitler, D.F, Satyshur, K.A, Forest, K.T, Gellman, S.H. | 登録日 | 2018-12-31 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin alpha 3 Toxicity. J.Am.Chem.Soc., 141, 2019
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7WRI
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![BU of 7wri by Molmil](/molmil-images/mine/7wri) | Cryo-EM structure of SARS-CoV-2 Omicron spike receptor-binding domain in complex with mouse ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein, ... | 著者 | Han, P, Xie, Y, Qi, J. | 登録日 | 2022-01-26 | 公開日 | 2022-06-08 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Broader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2s. Cell Discov, 8, 2022
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3D4X
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8DNL
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1RFN
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![BU of 1rfn by Molmil](/molmil-images/mine/1rfn) | HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE | 分子名称: | CALCIUM ION, P-AMINO BENZAMIDINE, PROTEIN (COAGULATION FACTOR IX), ... | 著者 | Hopfner, K.-P, Lang, A, Karcher, A, Sichler, K, Kopetzki, E, Brandstetter, H, Huber, R, Bode, W, Engh, R.A. | 登録日 | 1999-04-19 | 公開日 | 1999-09-01 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding. Structure Fold.Des., 7, 1999
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6BNE
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![BU of 6bne by Molmil](/molmil-images/mine/6bne) | Crystal structure of the intrinsic colistin resistance enzyme ICR(Mc) from Moraxella catarrhalis, catalytic domain, phosphate-bound complex | 分子名称: | ACETATE ION, GLYCEROL, PHOSPHATE ION, ... | 著者 | Stogios, P.J, Evdokimova, E, Wawrzak, Z, Di Leo, R, Savchenko, A, Anderson, W.F, Satchell, K.J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-11-16 | 公開日 | 2018-01-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Substrate recognition by a colistin resistance enzyme from Moraxella catarrhalis. ACS Chem. Biol., 2018
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3T2V
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![BU of 3t2v by Molmil](/molmil-images/mine/3t2v) | Crystal structure of the complex of peptidoglycan recognition protein-short (CPGRP-S) with mycolic acid at 2.5 A resolution | 分子名称: | (2S,3R)-2-hexyl-3-hydroxynonanoic acid, GLYCEROL, L(+)-TARTARIC ACID, ... | 著者 | Sharma, P, Dube, D, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | 登録日 | 2011-07-23 | 公開日 | 2011-08-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site Arch.Biochem.Biophys., 529, 2013
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6ITP
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![BU of 6itp by Molmil](/molmil-images/mine/6itp) | Crystal structure of cortisol complexed with its nanobody at pH 3.5 | 分子名称: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, anti-cortisol camelid antibody | 著者 | Ding, Y, Ding, L.L, Wang, Z.Y, Zhong, P.Y. | 登録日 | 2018-11-24 | 公開日 | 2019-07-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.572 Å) | 主引用文献 | Structural insights into the mechanism of single domain VHH antibody binding to cortisol. Febs Lett., 593, 2019
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6BJ5
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![BU of 6bj5 by Molmil](/molmil-images/mine/6bj5) | Structure of the Clinically used Myxomaviral Serine Protease Inhibitor 1 (SERP-1) | 分子名称: | 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mahon, B.P, Lomelino, C.L, McKenna, R. | 登録日 | 2017-11-05 | 公開日 | 2018-11-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the Clinically used Myxomaviral Serine Protease Inhibitor 1 (SERP-1) To Be Published
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4KEC
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![BU of 4kec by Molmil](/molmil-images/mine/4kec) | SbHCT-complex form | 分子名称: | (3R,4S,5R)-3,4-dihydroxy-5-{[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy}cyclohex-1-ene-1-carboxylic acid, COENZYME A, Hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transferase | 著者 | Walker, A.M, Hayes, R.P, Youn, B, Vermerris, W, Sattler, S.E, Kang, C. | 登録日 | 2013-04-25 | 公開日 | 2013-05-22 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Elucidation of the structure and reaction mechanism of sorghum hydroxycinnamoyltransferase and its structural relationship to other coenzyme a-dependent transferases and synthases. Plant Physiol., 162, 2013
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8DNA
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4HCY
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![BU of 4hcy by Molmil](/molmil-images/mine/4hcy) | Structure of a eukaryotic thiaminase-I bound to the thiamin analogue 3-deazathiamin | 分子名称: | 2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylthiophen-2-yl}ethanol, thiaminase-I | 著者 | Kreinbring, C.A, Hubbard, P.A, Leeper, F.J, Hawksley, D, Petsko, G.A, Ringe, D. | 登録日 | 2012-10-01 | 公開日 | 2013-10-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure of a eukaryotic thiaminase I. Proc.Natl.Acad.Sci.USA, 111, 2014
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2GEK
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![BU of 2gek by Molmil](/molmil-images/mine/2gek) | Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, PHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE (PimA) | 著者 | Guerin, M.E, Buschiazzo, A, Kordulakova, J, Jackson, M, Alzari, P.M. | 登録日 | 2006-03-20 | 公開日 | 2007-04-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria. J.Biol.Chem., 282, 2007
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