4HCY

Structure of a eukaryotic thiaminase-I bound to the thiamin analogue 3-deazathiamin

Summary for 4HCY

• Entry DOI: 10.2210/pdb4hcy/pdb
• Related: 4HCW
• Descriptor: thiaminase-I, 2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylthiophen-2-yl}ethanol (2 entities in total)
• Functional Keywords: transferase, thiamine pyridinylase
• Biological source: Naegleria gruberi (Amoeba)
• Total number of polymer chains: 6
• Total formula weight: 237290.81

Authors

Kreinbring, C.A.,Hubbard, P.A.,Leeper, F.J.,Hawksley, D.,Petsko, G.A.,Ringe, D. (deposition date: 2012-10-01, release date: 2013-10-02, Last modification date: 2023-09-20)

• Primary citation: Kreinbring, C.A.,Remillard, S.P.,Hubbard, P.,Brodkin, H.R.,Leeper, F.J.,Hawksley, D.,Lai, E.Y.,Fulton, C.,Petsko, G.A.,Ringe, D.; Structure of a eukaryotic thiaminase I.; Proc.Natl.Acad.Sci.USA, 111:137-142, 2014; PubMed: 24351929; DOI: 10.1073/pnas.1315882110

Experimental method

X-RAY DIFFRACTION (2.75 Å)