7W9T

Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV alpha helix conformer)

Summary for 7W9T

• Entry DOI: 10.2210/pdb7w9t/pdb
• EMDB information: 32372
• Descriptor: Sodium channel protein type 9 subunit alpha, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (11 entities in total)
• Functional Keywords: voltage gated sodium channel, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 298626.53

Authors

Yan, N.,Huang, G.,Liu, D.,Wei, P. (deposition date: 2021-12-10, release date: 2022-05-25)

• Primary citation: Huang, G.,Liu, D.,Wang, W.,Wu, Q.,Chen, J.,Pan, X.,Shen, H.,Yan, N.; High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.; Cell Rep, 39:110735-110735, 2022; PubMed: 35476982; DOI: 10.1016/j.celrep.2022.110735

Experimental method

ELECTRON MICROSCOPY (3 Å)