8SNK
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![BU of 8snk by Molmil](/molmil-images/mine/8snk) | Crystal structure of metformin hydrolase (MfmAB) from Pseudomonas mendocina sp. MET-2 mutant (MfmA/D188N) | 分子名称: | ZINC ION, metformin hydrolase subunit A, metformin hydrolase subunit B | 著者 | Tassoulas, L.J, Rankin, J.A, Elias, M.H, Wackett, L.P. | 登録日 | 2023-04-27 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes. Proc.Natl.Acad.Sci.USA, 121, 2024
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7VUN
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![BU of 7vun by Molmil](/molmil-images/mine/7vun) | Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction | 分子名称: | (2~{S},3~{S})-2-[[6-[(3-cyanophenyl)methoxy]-2-(2-methyl-3-phenyl-phenyl)-1,3-bis(oxidanylidene)isoindol-5-yl]methylamino]-3-oxidanyl-butanoic acid, Programmed cell death 1 ligand 1 | 著者 | Cheng, Y, Sun, C.L, Chen, M.R, Yang, P, Xiao, Y.B. | 登録日 | 2021-11-03 | 公開日 | 2022-09-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents. Acta Pharm Sin B, 12, 2022
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8CQ0
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![BU of 8cq0 by Molmil](/molmil-images/mine/8cq0) | Photorhabdus luminescens TcdA1 prepore-to-pore intermediate, K567W K2008W mutant | 分子名称: | TcdA1 | 著者 | Nganga, P.N, Roderer, D, Belyy, A, Prumbaum, D, Raunser, S. | 登録日 | 2023-03-03 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Kinetics of the syringe-like injection mechanism of Tc toxins to be published
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3EMW
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![BU of 3emw by Molmil](/molmil-images/mine/3emw) | Crystal Structure of human splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2) in complex with a 20-residue VASA peptide | 分子名称: | 1,2-ETHANEDIOL, Peptide (VASA), SPRY domain-containing SOCS box protein 2 | 著者 | Filippakopoulos, P, Sharpe, T, Keates, T, Murray, J.W, Savitsky, P, Roos, A.K, Pike, A.C.W, Von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC) | 登録日 | 2008-09-25 | 公開日 | 2008-10-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. J.Mol.Biol., 401, 2010
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4MDF
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![BU of 4mdf by Molmil](/molmil-images/mine/4mdf) | Structure of bacterial polynucleotide kinase Michaelis complex bound to GTP and DNA | 分子名称: | CITRIC ACID, DNA (5'-D(*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Shuman, S, Das, U, Wang, L.K, Smith, P, Jacewicz, A. | 登録日 | 2013-08-22 | 公開日 | 2013-11-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.727 Å) | 主引用文献 | Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Res., 42, 2014
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6LNI
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![BU of 6lni by Molmil](/molmil-images/mine/6lni) | Cryo-EM structure of amyloid fibril formed by full-length human prion protein | 分子名称: | Major prion protein | 著者 | Wang, L.Q, Zhao, K, Yuan, H.Y, Wang, Q, Guan, Z.Y, Tao, J, Li, X.N, Hao, M.M, Chen, J, Zhang, D.L, Zhu, H.L, Yin, P, Liu, C, Liang, Y. | 登録日 | 2019-12-30 | 公開日 | 2020-06-10 | 最終更新日 | 2020-06-24 | 実験手法 | ELECTRON MICROSCOPY (2.702 Å) | 主引用文献 | Cryo-EM structure of an amyloid fibril formed by full-length human prion protein. Nat.Struct.Mol.Biol., 27, 2020
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6UGA
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![BU of 6uga by Molmil](/molmil-images/mine/6uga) | ch28/11 Fab (monoclinic form) | 分子名称: | ch28/11 Fab heavy chain, ch28/11 Fab light chain, methanesulfonic acid | 著者 | Soliman, C, Ramsland, P.A. | 登録日 | 2019-09-26 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody. J.Biol.Chem., 295, 2020
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1EUM
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![BU of 1eum by Molmil](/molmil-images/mine/1eum) | CRYSTAL STRUCTURE OF THE E.COLI FERRITIN ECFTNA | 分子名称: | FERRITIN 1 | 著者 | Stillman, T.J, Hempstead, P.D, Artymiuk, P.J, Andrews, S.C, Hudson, A.J, Treffry, A, Guest, J.R, Harrison, P.M. | 登録日 | 2000-04-17 | 公開日 | 2001-03-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The high-resolution X-ray crystallographic structure of the ferritin (EcFtnA) of Escherichia coli; comparison with human H ferritin (HuHF) and the structures of the Fe(3+) and Zn(2+) derivatives. J.Mol.Biol., 307, 2001
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6U9L
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![BU of 6u9l by Molmil](/molmil-images/mine/6u9l) | Imidazole-triggered RAS-specific subtilisin SUBT_BACAM | 分子名称: | GLYCEROL, POTASSIUM ION, SUBTILISIN BPN', ... | 著者 | Toth, E.A, Bryan, P.N, Orban, J. | 登録日 | 2019-09-09 | 公開日 | 2020-09-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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4QGC
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![BU of 4qgc by Molmil](/molmil-images/mine/4qgc) | crystal structure of PKM2-K422R mutant | 分子名称: | GLYCEROL, POTASSIUM ION, Pyruvate kinase PKM, ... | 著者 | Wang, P, Sun, C, Zhu, T, Xu, Y. | 登録日 | 2014-05-22 | 公開日 | 2015-02-25 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | 主引用文献 | Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell, 6, 2015
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8RU2
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![BU of 8ru2 by Molmil](/molmil-images/mine/8ru2) | Structure of the F-actin barbed end bound by formin mDia1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. | 登録日 | 2024-01-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
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6LXE
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![BU of 6lxe by Molmil](/molmil-images/mine/6lxe) | DROSHA-DGCR8 complex | 分子名称: | Microprocessor complex subunit DGCR8, Ribonuclease 3, ZINC ION | 著者 | Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M. | 登録日 | 2020-02-10 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural Basis for pri-miRNA Recognition by Drosha. Mol.Cell, 78, 2020
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5E5Q
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![BU of 5e5q by Molmil](/molmil-images/mine/5e5q) | Racemic snakin-1 in P21/c | 分子名称: | Snakin-1 | 著者 | Yeung, H, Squire, C.J, Yosaatmadja, Y, Panjikar, S, Baker, E.N, Harris, P.W.R, Brimble, M.A. | 登録日 | 2015-10-09 | 公開日 | 2016-05-18 | 最終更新日 | 2016-07-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily. Angew.Chem.Int.Ed.Engl., 55, 2016
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5EAX
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![BU of 5eax by Molmil](/molmil-images/mine/5eax) | Crystal structure of Dna2 in complex with an ssDNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication ATP-dependent helicase/nuclease DNA2, ... | 著者 | Zhou, C, Pourmal, S, Pavletich, N.P. | 登録日 | 2015-10-17 | 公開日 | 2015-11-18 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife, 4, 2015
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3S3X
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![BU of 3s3x by Molmil](/molmil-images/mine/3s3x) | Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive cation channel 2, neuronal, ... | 著者 | Dawson, R.J.P, Benz, J, Stohler, P, Tetaz, T, Joseph, C, Huber, S, Schmid, G, Huegin, D, Pflimlin, P, Trube, G, Rudolph, M.G, Hennig, M, Ruf, A. | 登録日 | 2011-05-18 | 公開日 | 2012-05-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1. Nat Commun, 3, 2012
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4CZS
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![BU of 4czs by Molmil](/molmil-images/mine/4czs) | Discovery of Glycomimetic Ligands via Genetically-encoded Library of Phage displaying Mannose-peptides | 分子名称: | 2-hydroxyethyl alpha-D-mannopyranoside, CALCIUM ION, Concanavalin V, ... | 著者 | Ng, S, Lin, E, Tjhung, K.F, Gerlits, O, Sood, A, Kasper, B, Deng, L, Kitov, P.I, Matochko, W.L, Paschal, B.M, Noren, C.J, Klassen, J, Mahal, L.K, Coates, L, Woods, R.J, Derda, R. | 登録日 | 2014-04-22 | 公開日 | 2015-04-22 | 最終更新日 | 2022-12-07 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Genetically-Encoded Fragment-Based Discovery of Glycopeptide Ligands for Carbohydrate-Binding Proteins. J.Am.Chem.Soc., 137, 2015
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7VH4
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![BU of 7vh4 by Molmil](/molmil-images/mine/7vh4) | |
3ES6
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![BU of 3es6 by Molmil](/molmil-images/mine/3es6) | Crystal structure of the novel complex formed between Zinc 2-glycoprotein (ZAG) and Prolactin inducible protein (PIP) from human seminal plasma | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, HEXAETHYLENE GLYCOL, ... | 著者 | Hassan, M.I, Bilgrami, S, Kumar, V, Singh, N, Yadav, S, Kaur, P, Singh, T.P. | 登録日 | 2008-10-04 | 公開日 | 2008-10-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | 主引用文献 | Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma J.Mol.Biol., 384, 2008
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6URE
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![BU of 6ure by Molmil](/molmil-images/mine/6ure) | Barrier-to-autointegration factor Aqueous: 1 of 14 in MSCS set | 分子名称: | Barrier-to-autointegration factor, ETHANOL | 著者 | Agarwal, S, Smith, M, De La Rosa, I, Kliment, A.V, Swartz, P, Segura-Totten, M, Mattos, C. | 登録日 | 2019-10-23 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.653 Å) | 主引用文献 | Development of a structure-analysis pipeline using multiple-solvent crystal structures of barrier-to-autointegration factor. Acta Crystallogr D Struct Biol, 76, 2020
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6URK
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![BU of 6urk by Molmil](/molmil-images/mine/6urk) | Barrier-to-autointegration factor soaked in Glycerol: 1 of 14 in MSCS set | 分子名称: | Barrier-to-autointegration factor, ETHANOL | 著者 | Agarwal, S, Smith, M, De La Rosa, I, Kliment, A.V, Swartz, P, Segura-Totten, M, Mattos, C. | 登録日 | 2019-10-23 | 公開日 | 2020-10-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Development of a structure-analysis pipeline using multiple-solvent crystal structures of barrier-to-autointegration factor. Acta Crystallogr D Struct Biol, 76, 2020
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6UQN
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2C1H
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![BU of 2c1h by Molmil](/molmil-images/mine/2c1h) | The X-ray Structure of Chlorobium vibrioforme 5-Aminolaevulinic Acid Dehydratase Complexed with a Diacid Inhibitor | 分子名称: | 4,7-DIOXOSEBACIC ACID, DELTA-AMINOLEVULINIC ACID DEHYDRATASE, MAGNESIUM ION | 著者 | Coates, L, Beaven, G, Erskine, P.T, Beale, S, Wood, S.P, Shoolingin-Jordan, P.M, Cooper, J.B. | 登録日 | 2005-09-14 | 公開日 | 2005-12-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of Chlorobium Vibrioforme 5-Aminolaevulinic Acid Dehydratase Complexed with a Diacid Inhibitor. Acta Crystallogr.,Sect.D, 61, 2005
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6USD
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![BU of 6usd by Molmil](/molmil-images/mine/6usd) | Barrier-to-autointegration factor soaked in ethanol: 1 of 14 in MSCS set | 分子名称: | Barrier-to-autointegration factor, ETHANOL | 著者 | Agarwal, S, Smith, M, De La Rosa, I, Kliment, A.V, Swartz, P, Segura-Totten, M, Mattos, C. | 登録日 | 2019-10-25 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.653 Å) | 主引用文献 | Development of a structure-analysis pipeline using multiple-solvent crystal structures of barrier-to-autointegration factor. Acta Crystallogr D Struct Biol, 76, 2020
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4Q0N
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![BU of 4q0n by Molmil](/molmil-images/mine/4q0n) | Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand | 分子名称: | (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, Protein polybromo-1 | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Monteiro, O, Fedorov, O, Chaikuad, A, Yue, W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2014-04-02 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand To be Published
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3NYO
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![BU of 3nyo by Molmil](/molmil-images/mine/3nyo) | Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with AMP | 分子名称: | (R,R)-2,3-BUTANEDIOL, ADENOSINE MONOPHOSPHATE, G protein-coupled receptor kinase 6, ... | 著者 | Tesmer, J.J.G, Singh, P. | 登録日 | 2010-07-15 | 公開日 | 2010-09-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Molecular basis for activation of G protein-coupled receptor kinases. Embo J., 29, 2010
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