4Q0N

Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand

Summary for 4Q0N

• Entry DOI: 10.2210/pdb4q0n/pdb
• Related: 4Q0O
• Descriptor: Protein polybromo-1, 1,2-ETHANEDIOL, (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one, ... (4 entities in total)
• Functional Keywords: pb1, polybromo 1 isoform 1, baf180, polybromo-1d, pbrm1, brg1-associated factor 180, bromodomain, chromatin regulator, dna-binding, nucleus, transcription, transcription regulation, structural genomics consortium, sgc
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q86U86
• Total number of polymer chains: 8
• Total formula weight: 139670.43

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Monteiro, O.,Fedorov, O.,Chaikuad, A.,Yue, W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-04-02, release date: 2014-05-07, Last modification date: 2023-09-20)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Monteiro, O.,Fedorov, O.,Chaikuad, A.,Yue, W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC); Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (1.78 Å)