4Q0N
Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Protein polybromo-1 | polymer | 145 | 17119.7 | 8 | UniProt (Q86U86) Pfam (PF00439) In PDB | Homo sapiens (human) | hPB1, BRG1-associated factor 180, BAF180, Polybromo-1D |
2 | A, C, D, E, F... | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
3 | A, B, C, D, E... | (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one | non-polymer | 269.3 | 8 | Chemie (2XD) | |||
4 | water | water | 18.0 | 545 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 613 - 734 (UniProt: Q86U86)
PDB | External Database | Details |
---|---|---|
Met 590 | - | expression tag |
His 591 | - | expression tag |
His 592 | - | expression tag |
His 593 | - | expression tag |
His 594 | - | expression tag |
His 595 | - | expression tag |
His 596 | - | expression tag |
Ser 597 | - | expression tag |
Ser 598 | - | expression tag |
Gly 599 | - | expression tag |
Val 600 | - | expression tag |
Asp 601 | - | expression tag |
Leu 602 | - | expression tag |
Gly 603 | - | expression tag |
Thr 604 | - | expression tag |
Glu 605 | - | expression tag |
Asn 606 | - | expression tag |
Leu 607 | - | expression tag |
Tyr 608 | - | expression tag |
Phe 609 | - | expression tag |
Gln 610 | - | expression tag |
Ser 611 | - | expression tag |
Met 612 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 136957.4 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 2713.0 | |
All* | Total formula weight | 139670.4 |