4Q0N

Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006338	biological_process	chromatin remodeling
A	0016586	cellular_component	RSC-type complex
B	0006338	biological_process	chromatin remodeling
B	0016586	cellular_component	RSC-type complex
C	0006338	biological_process	chromatin remodeling
C	0016586	cellular_component	RSC-type complex
D	0006338	biological_process	chromatin remodeling
D	0016586	cellular_component	RSC-type complex
E	0006338	biological_process	chromatin remodeling
E	0016586	cellular_component	RSC-type complex
F	0006338	biological_process	chromatin remodeling
F	0016586	cellular_component	RSC-type complex
G	0006338	biological_process	chromatin remodeling
G	0016586	cellular_component	RSC-type complex
H	0006338	biological_process	chromatin remodeling
H	0016586	cellular_component	RSC-type complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 801

Chain	Residue
A	PHE700
A	ASN701
A	CYS704
A	LEU718
A	HIS721
E	ARG658
E	TYR665
E	HOH921

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2XD A 802

Chain	Residue
A	PHE652
A	PRO656
A	GLU660
A	LEU661
A	TYR664
A	MET672
A	ALA703
A	ASN707
A	ILE713
A	HOH919
A	ILE651

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2XD B 801

Chain	Residue
B	ILE651
B	PHE652
B	LEU655
B	TYR664
B	MET672
B	ALA703
B	ASN707
B	HOH909
B	HOH923
D	2XD802

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 801

Chain	Residue
C	ARG646
C	LYS715
C	ASP716
C	HOH948
G	GLU660

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2XD C 802

Chain	Residue
C	ILE651
C	PHE652
C	LEU655
C	PRO656
C	TYR664
C	MET672
C	ALA703
C	ASN707
C	ILE713
C	HOH931

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 801

Chain	Residue
D	PHE700
D	ASN701
D	CYS704
D	LEU718
D	HIS721

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2XD D 802

Chain	Residue
B	2XD801
D	ILE651
D	PHE652
D	LEU655
D	PRO656
D	GLU660
D	TYR664
D	MET672
D	ALA703
D	ASN707
D	ILE713
D	HOH917
D	HOH952

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 801

Chain	Residue
A	ARG658
A	TYR665
E	PHE700
E	ASN701
E	CYS704
E	HIS721
E	HOH941

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 802

Chain	Residue
E	PRO656
E	SER657
E	GLU660
H	GLU710
H	LEU712
H	LYS715

---

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2XD E 803

Chain	Residue
E	ILE651
E	PHE652
E	PRO656
E	GLU660
E	TYR664
E	MET672
E	ALA703
E	ASN707
E	ILE713
E	HOH913
H	2XD802

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F 801

Chain	Residue
A	HOH913
F	ILE651
F	LEU712
F	ASP716
F	HOH906
F	HOH931

---

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2XD F 802

Chain	Residue
F	TYR664
F	MET672
F	ALA703
F	ASN707
A	ILE651
A	LEU712
A	HOH911
A	HOH917
F	ILE651
F	PHE652
F	LEU655

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO G 801

Chain	Residue
G	PHE700
G	ASN701
G	CYS704
G	LEU718
G	HIS721
G	HOH938

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO G 802

Chain	Residue
C	ALA650
C	ILE651
C	HOH927
G	ILE651
G	ASP716
G	HOH908

---

site_id	BC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2XD G 803

Chain	Residue
C	HOH903
G	ILE651
G	PHE652
G	LEU655
G	TYR664
G	MET672
G	MET699
G	ALA703
G	ASN707
G	ILE713
G	HOH903

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO H 801

Chain	Residue
H	ILE651
H	ILE713
H	ASP716
H	HOH908
H	HOH943
H	HOH965

---

site_id	BC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2XD H 802

Chain	Residue
E	ILE651
E	LEU712
E	ILE713
E	2XD803
E	HOH934
H	ILE651
H	PHE652
H	LEU655
H	TYR664
H	MET672
H	ALA703
H	ASN707
H	HOH915

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY

Chain	Residue	Details
A	SER649-TYR706

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER616
B	SER616
C	SER616
D	SER616
E	SER616
F	SER616
G	SER616
H	SER616

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER657
B	SER657
C	SER657
D	SER657
E	SER657
F	SER657
G	SER657
H	SER657

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS621
F	LYS621
G	LYS621
H	LYS621
B	LYS621
C	LYS621
D	LYS621
E	LYS621

---