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PDB: 63 件
1W4S
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BU of 1w4s by Molmil
Crystal structure of the proximal BAH domain of polybromo
分子名称: CHLORIDE ION, POLYBROMO 1 PROTEIN
著者Oliver, A.W, Roe, S.M, Pearl, L.H.
登録日2004-07-28
公開日2005-04-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal Structure of the Proximal Bah Domain of the Polybromo Protein
Biochem.J., 389, 2005
4U6A
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BU of 4u6a by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
分子名称: 1,2-ETHANEDIOL, 3-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)-5-methylisoquinolin-1(2H)-one, GLYCEROL, ...
著者Oliver, A.W.
登録日2014-07-28
公開日2015-07-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Design and discovery of 3-aryl-5-substituted-isoquinolin-1- ones as potent and selective tankyrase inhibitors
To be published
3EU7
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BU of 3eu7 by Molmil
Crystal Structure of a PALB2 / BRCA2 complex
分子名称: 19meric peptide from Breast cancer type 2 susceptibility protein, GLYCEROL, Partner and localizer of BRCA2
著者Oliver, A.W, Pearl, L.H.
登録日2008-10-09
公開日2009-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for recruitment of BRCA2 by PALB2
Embo Rep., 10, 2009
1GS0
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BU of 1gs0 by Molmil
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2
分子名称: POLY (ADP-RIBOSE) POLYMERASE-2
著者Oliver, A.W, Roe, S.M, Pearl, L.H.
登録日2001-12-19
公開日2002-12-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Catalytic Fragment of Murine Poly(Adp-Ribose) Polymerase-2
Nucleic Acids Res., 32, 2004
4UUH
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BU of 4uuh by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
分子名称: 1,2-ETHANEDIOL, 5-methyl-3-[4-(piperazin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one, GLYCEROL, ...
著者Oliver, A.W, Rajasekaran, M.B, Pearl, L.H.
登録日2014-07-28
公開日2015-07-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors
Medchemcommm, 6, 2015
4UW1
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BU of 4uw1 by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
分子名称: 1,2-ETHANEDIOL, 3-{4-[(dimethylamino)methyl]phenyl}-5-methoxyisoquinolin-1(2H)-one, GLYCEROL, ...
著者Oliver, A.W, Rajasekaran, M.B, Pearl, L.H.
登録日2014-08-08
公開日2015-07-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.37 Å)
主引用文献Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors
Medchemcommm, 6, 2015
2BRF
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BU of 2brf by Molmil
Crystal Structure of the FHA Domain of Human Polynucleotide Kinase 3' Phosphatase
分子名称: BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, SULFATE ION
著者Oliver, A.W, Ali, A.A.E, Pearl, L.H.
登録日2005-05-04
公開日2005-05-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Nucleic Acids Res., 37, 2009
2CN8
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BU of 2cn8 by Molmil
Crystal structure of human Chk2 in complex with debromohymenialdisine
分子名称: DEBROMOHYMENIALDISINE, MAGNESIUM ION, NITRATE ION, ...
著者Oliver, A.W, Pearl, L.H.
登録日2006-05-18
公開日2006-06-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
Embo J., 25, 2006
2CN5
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BU of 2cn5 by Molmil
Crystal structure of human Chk2 in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Oliver, A.W, Pearl, L.H.
登録日2006-05-18
公開日2006-06-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
Embo J., 25, 2006
2W3O
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BU of 2w3o by Molmil
Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide
分子名称: BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, CALCIUM ION, DNA REPAIR PROTEIN XRCC1
著者Oliver, A.W, Ali, A.A.E, Pearl, L.H.
登録日2008-11-13
公開日2009-02-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Nucleic Acids Res., 37, 2009
2W18
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BU of 2w18 by Molmil
Crystal structure of the C-terminal WD40 domain of human PALB2
分子名称: GLYCEROL, PARTNER AND LOCALIZER OF BRCA2
著者Oliver, A.W, Pearl, L.H.
登録日2008-10-15
公開日2009-07-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Recruitment of Brca2 by Palb2
Embo Rep., 10, 2009
5HY6
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BU of 5hy6 by Molmil
Spodoptera frugiperda eukaryotic translation initiation factor EIF5A
分子名称: Eukaryotic translation initiation factor 5A
著者Li, A.W.H, Oliver, A.W, Pearl, L.H.
登録日2016-02-01
公開日2016-02-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.186 Å)
主引用文献Structure of Spodoptera frugiperda eukaryotic translation initiation factor EIF5A
To Be Published
6RMM
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BU of 6rmm by Molmil
Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide
分子名称: 53BP1, DNA topoisomerase 2-binding protein 1
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2019-05-07
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.53 Å)
主引用文献Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
6RML
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BU of 6rml by Molmil
Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide
分子名称: 53BP1, DNA topoisomerase 2-binding protein 1
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2019-05-07
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
5ECG
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BU of 5ecg by Molmil
Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)
分子名称: Cellular tumor antigen p53, SEP-GLN-GLU-TYR, Tumor suppressor p53-binding protein 1, ...
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2015-10-20
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX.
Cell Rep, 13, 2015
8OK2
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BU of 8ok2 by Molmil
Bipartite interaction of TOPBP1 with the GINS complex
分子名称: DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ...
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2023-03-26
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献TopBP1 utilises a bipartite GINS binding mode to support genome replication.
Nat Commun, 15, 2024
7AUC
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BU of 7auc by Molmil
Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
著者Chen, X, Oliver, A.W.
登録日2020-11-02
公開日2020-12-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Elife, 10, 2021
7P0L
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BU of 7p0l by Molmil
Crystal structure of S.pombe Mdb1 BRCT domains in complex with a H2A phosphopeptide
分子名称: DNA damage response protein Mdb1, Histone H2A-beta
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2021-06-29
公開日2021-12-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.
DNA Repair (Amst), 108, 2021
7P0J
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BU of 7p0j by Molmil
Crystal structure of S.pombe Mdb1 BRCT domains
分子名称: CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ...
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2021-06-29
公開日2022-07-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.
DNA Repair (Amst), 108, 2021
7AUD
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BU of 7aud by Molmil
Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
分子名称: ADENOSINE-5'-DIPHOSPHATE, Bloom syndrome protein,Bloom syndrome protein, DNA (5'-D(*GP*TP*AP*CP*CP*CP*GP*AP*TP*GP*TP*GP*T)-3'), ...
著者Chen, X, Oliver, A.W.
登録日2020-11-02
公開日2020-12-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Elife, 10, 2021
7QCD
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BU of 7qcd by Molmil
CryoEM structure of the Smc5/6-holocomplex (composite structure)
分子名称: E3 SUMO-protein ligase MMS21, Non-structural maintenance of chromosome element 3, Non-structural maintenance of chromosome element 4, ...
著者Hallett, S.T, Oliver, A.W.
登録日2021-11-23
公開日2022-09-21
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (8 Å)
主引用文献Cryo-EM structure of the Smc5/6 holo-complex.
Nucleic Acids Res., 50, 2022
7AKO
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BU of 7ako by Molmil
Crystal structure of CHK1 kinase domain in complex with a CLASPIN phosphopeptide
分子名称: 1,2-ETHANEDIOL, Claspin, STAUROSPORINE, ...
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2020-10-01
公開日2021-04-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein.
Structure, 29, 2021
7AKM
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BU of 7akm by Molmil
Crystal structure of CHK1 kinase domain in complex with ATPyS
分子名称: 1,2-ETHANEDIOL, CITRIC ACID, MAGNESIUM ION, ...
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2020-10-01
公開日2021-04-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein.
Structure, 29, 2021
5MG8
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BU of 5mg8 by Molmil
Crystal structure of the S.pombe Smc5/6 hinge domain
分子名称: GLYCEROL, SULFATE ION, Structural maintenance of chromosomes protein 5, ...
著者Alt, A, Pearl, L.H, Oliver, A.W.
登録日2016-11-21
公開日2017-02-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Specialized interfaces of Smc5/6 control hinge stability and DNA association.
Nat Commun, 8, 2017
5LOH
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BU of 5loh by Molmil
Kinase domain of human Greatwall
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, STAUROSPORINE, ...
著者Rajasekaran, M.B, Pearl, L.H, Oliver, A.W.
登録日2016-08-09
公開日2016-09-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.
Oncotarget, 7, 2016

 

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