8OK2

Bipartite interaction of TOPBP1 with the GINS complex

Summary for 8OK2

• Entry DOI: 10.2210/pdb8ok2/pdb
• EMDB information: 16916
• Descriptor: DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ... (5 entities in total)
• Functional Keywords: scaffold, replisome, recruitment, replication
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 147018.11

Authors

Day, M.,Oliver, A.W.,Pearl, L.H. (deposition date: 2023-03-26, release date: 2024-03-13)

• Primary citation: Day, M.,Tetik, B.,Parlak, M.,Almeida-Hernandez, Y.,Raschle, M.,Kaschani, F.,Siegert, H.,Marko, A.,Sanchez-Garcia, E.,Kaiser, M.,Barker, I.A.,Pearl, L.H.,Oliver, A.W.,Boos, D.; TopBP1 utilises a bipartite GINS binding mode to support genome replication.; Nat Commun, 15:1797-1797, 2024; PubMed: 38413589; DOI: 10.1038/s41467-024-45946-0

Experimental method

ELECTRON MICROSCOPY (4.1 Å)