8OK2

Bipartite interaction of TOPBP1 with the GINS complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000811	cellular_component	GINS complex
A	0006260	biological_process	DNA replication
B	0000228	cellular_component	nuclear chromosome
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000811	cellular_component	GINS complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006268	biological_process	DNA unwinding involved in DNA replication
B	0032993	cellular_component	protein-DNA complex
B	0071162	cellular_component	CMG complex
C	0000811	cellular_component	GINS complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006260	biological_process	DNA replication
C	0006268	biological_process	DNA unwinding involved in DNA replication
C	0071162	cellular_component	CMG complex
C	1902975	biological_process	mitotic DNA replication initiation
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000811	cellular_component	GINS complex
D	0001833	biological_process	inner cell mass cell proliferation
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006268	biological_process	DNA unwinding involved in DNA replication
D	0071162	cellular_component	CMG complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
D	MET1

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processed => ECO:0007744|PubMed:21406692

Chain	Residue	Details
D	THR2

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
D	SER12
D	SER16

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS109

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