8OK2
Bipartite interaction of TOPBP1 with the GINS complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000811 | cellular_component | GINS complex |
| A | 0006260 | biological_process | DNA replication |
| B | 0000727 | biological_process | double-strand break repair via break-induced replication |
| B | 0000811 | cellular_component | GINS complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0006260 | biological_process | DNA replication |
| B | 0071162 | cellular_component | CMG complex |
| C | 0000811 | cellular_component | GINS complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005694 | cellular_component | chromosome |
| C | 0006260 | biological_process | DNA replication |
| C | 0035264 | biological_process | multicellular organism growth |
| C | 0071162 | cellular_component | CMG complex |
| C | 0090398 | biological_process | cellular senescence |
| D | 0000727 | biological_process | double-strand break repair via break-induced replication |
| D | 0000811 | cellular_component | GINS complex |
| D | 0001833 | biological_process | inner cell mass cell proliferation |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005694 | cellular_component | chromosome |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006260 | biological_process | DNA replication |
| D | 0006261 | biological_process | DNA-templated DNA replication |
| D | 0071162 | cellular_component | CMG complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | Region: {"description":"Not essential for folding and stability of GINS complex, but may regulate accessibility to the central complex pore"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | Region: {"description":"Important for GINS complex assembly"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 97 |
| Details | Domain: {"description":"BRCT 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00033","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
