8OK2
Bipartite interaction of TOPBP1 with the GINS complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000811 | cellular_component | GINS complex |
| A | 0006260 | biological_process | DNA replication |
| B | 0000727 | biological_process | double-strand break repair via break-induced replication |
| B | 0000811 | cellular_component | GINS complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0006260 | biological_process | DNA replication |
| B | 0071162 | cellular_component | CMG complex |
| C | 0000811 | cellular_component | GINS complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005694 | cellular_component | chromosome |
| C | 0006260 | biological_process | DNA replication |
| C | 0035264 | biological_process | multicellular organism growth |
| C | 0071162 | cellular_component | CMG complex |
| C | 0090398 | biological_process | cellular senescence |
| D | 0000727 | biological_process | double-strand break repair via break-induced replication |
| D | 0000811 | cellular_component | GINS complex |
| D | 0001833 | biological_process | inner cell mass cell proliferation |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005694 | cellular_component | chromosome |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006260 | biological_process | DNA replication |
| D | 0006261 | biological_process | DNA-templated DNA replication |
| D | 0071162 | cellular_component | CMG complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| D | MET1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processed => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| D | THR2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| D | SER12 | |
| D | SER16 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS109 |
