5LOH

Kinase domain of human Greatwall

Summary for 5LOH

Entry DOI	10.2210/pdb5loh/pdb
Descriptor	Serine/threonine-protein kinase greatwall,Serine/threonine-protein kinase greatwall, STAUROSPORINE, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	kinase domain, inhibitor, transferase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: Q96GX5
Total number of polymer chains	2
Total formula weight	77583.74
Authors	Rajasekaran, M.B.,Pearl, L.H.,Oliver, A.W. (deposition date: 2016-08-09, release date: 2016-09-07, Last modification date: 2024-01-10)
Primary citation	Ocasio, C.A.,Rajasekaran, M.B.,Walker, S.,Le Grand, D.,Spencer, J.,Pearl, F.M.,Ward, S.E.,Savic, V.,Pearl, L.H.,Hochegger, H.,Oliver, A.W. A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7:71182-71197, 2016 Cited by PubMed: 27563826 DOI: 10.18632/oncotarget.11511 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation