7AUD
Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
Summary for 7AUD
Entry DOI | 10.2210/pdb7aud/pdb |
Descriptor | Bloom syndrome protein,Bloom syndrome protein, DNA (5'-D(*GP*TP*AP*CP*CP*CP*GP*AP*TP*GP*TP*GP*T)-3'), ZINC ION, ... (8 entities in total) |
Functional Keywords | helicase, recq, blm, dna repair, inhibitor, allosteric, nuclear protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 417975.02 |
Authors | Chen, X.,Oliver, A.W. (deposition date: 2020-11-02, release date: 2020-12-16, Last modification date: 2024-01-31) |
Primary citation | Chen, X.,Ali, Y.I.,Fisher, C.E.,Arribas-Bosacoma, R.,Rajasekaran, M.B.,Williams, G.,Walker, S.,Booth, J.R.,Hudson, J.J.,Roe, S.M.,Pearl, L.H.,Ward, S.E.,Pearl, F.M.,Oliver, A.W. Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Elife, 10:-, 2021 Cited by PubMed: 33647232DOI: 10.7554/eLife.65339 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.96 Å) |
Structure validation
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