7AUD
Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006310 | biological_process | DNA recombination |
| A | 0044237 | biological_process | cellular metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006310 | biological_process | DNA recombination |
| B | 0044237 | biological_process | cellular metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006310 | biological_process | DNA recombination |
| C | 0044237 | biological_process | cellular metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004386 | molecular_function | helicase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006310 | biological_process | DNA recombination |
| D | 0044237 | biological_process | cellular metabolic process |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0003676 | molecular_function | nucleic acid binding |
| E | 0004386 | molecular_function | helicase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006310 | biological_process | DNA recombination |
| E | 0044237 | biological_process | cellular metabolic process |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0003676 | molecular_function | nucleic acid binding |
| F | 0004386 | molecular_function | helicase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006310 | biological_process | DNA recombination |
| F | 0044237 | biological_process | cellular metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00690 |
| Number of Residues | 10 |
| Details | DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ArFVIDEAHC |
| Chain | Residue | Details |
| A | ALA790-CYS799 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CDG, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
| Chain | Residue | Details |
| A | PHE668 | |
| B | CYS1055 | |
| B | CYS1063 | |
| B | CYS1066 | |
| C | PHE668 | |
| C | GLY692 | |
| C | CYS1036 | |
| C | CYS1055 | |
| C | CYS1063 | |
| C | CYS1066 | |
| D | PHE668 | |
| A | GLY692 | |
| D | GLY692 | |
| D | CYS1036 | |
| D | CYS1055 | |
| D | CYS1063 | |
| D | CYS1066 | |
| E | PHE668 | |
| E | GLY692 | |
| E | CYS1036 | |
| E | CYS1055 | |
| E | CYS1063 | |
| A | CYS1036 | |
| E | CYS1066 | |
| F | PHE668 | |
| F | GLY692 | |
| F | CYS1036 | |
| F | CYS1055 | |
| F | CYS1063 | |
| F | CYS1066 | |
| A | CYS1055 | |
| A | CYS1063 | |
| A | CYS1066 | |
| B | PHE668 | |
| B | GLY692 | |
| B | CYS1036 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CDG, ECO:0007744|PDB:4CGZ |
| Chain | Residue | Details |
| A | ARG982 | |
| E | ASN1242 | |
| F | ARG982 | |
| F | ASN1242 | |
| A | ASN1242 | |
| B | ARG982 | |
| B | ASN1242 | |
| C | ARG982 | |
| C | ASN1242 | |
| D | ARG982 | |
| D | ASN1242 | |
| E | ARG982 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | SITE: 3' overhang DNA-binding => ECO:0000269|PubMed:25901030 |
| Chain | Residue | Details |
| A | ARG717 | |
| E | ARG808 | |
| F | ARG717 | |
| F | ARG808 | |
| A | ARG808 | |
| B | ARG717 | |
| B | ARG808 | |
| C | ARG717 | |
| C | ARG808 | |
| D | ARG717 | |
| D | ARG808 | |
| E | ARG717 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: 3' overhang DNA-binding; via amide nitrogen => ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
| Chain | Residue | Details |
| A | ALA920 | |
| B | ALA920 | |
| C | ALA920 | |
| D | ALA920 | |
| E | ALA920 | |
| F | ALA920 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | SITE: 3' overhang DNA-binding => ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
| Chain | Residue | Details |
| A | THR946 | |
| E | LYS968 | |
| F | THR946 | |
| F | LYS968 | |
| A | LYS968 | |
| B | THR946 | |
| B | LYS968 | |
| C | THR946 | |
| C | LYS968 | |
| D | THR946 | |
| D | LYS968 | |
| E | THR946 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS863 | |
| B | LYS863 | |
| C | LYS863 | |
| D | LYS863 | |
| E | LYS863 | |
| F | LYS863 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER1295 | |
| E | SER1296 | |
| F | SER1295 | |
| F | SER1296 | |
| A | SER1296 | |
| B | SER1295 | |
| B | SER1296 | |
| C | SER1295 | |
| C | SER1296 | |
| D | SER1295 | |
| D | SER1296 | |
| E | SER1295 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS1207 | |
| F | LYS1207 | |
| B | LYS1207 | |
| C | LYS1207 | |
| D | LYS1207 | |
| E | LYS1207 |
