4UW1
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Summary for 4UW1
Entry DOI | 10.2210/pdb4uw1/pdb |
Related | 4UUH |
Descriptor | TANKYRASE-1, ZINC ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | transferase, tnks, inhibitor, wnt signalling |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: O95271 |
Total number of polymer chains | 8 |
Total formula weight | 238789.41 |
Authors | Oliver, A.W.,Rajasekaran, M.B.,Pearl, L.H. (deposition date: 2014-08-08, release date: 2015-07-08, Last modification date: 2024-01-10) |
Primary citation | Elliot, R.J.,Jarvis, A.,Rajasekaran, M.B.,Menon, M.,Bowers, L.,Boffey, R.,Bayford, M.,Firth-Clark, S.,Beevers, R.,Aquil, R.,Kirton, S.B.,Niculescu-Duvaz, D.,Fish, L.,Lopes, F.,Mcleary, R.,Trindade, I.,Vendrell, E.,Munkonge, F.,Porter, R.,Perrior, T.,Springer, C.,Oliver, A.W.,Pearl, L.H.,Ashworth, A.,Lord, C.J. Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors Medchemcommm, 6:1687-, 2015 Cited by DOI: 10.1039/C5MD00210APDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.37 Å) |
Structure validation
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