4UW1
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | TANKYRASE-1 | polymer | 258 | 29417.1 | 8 | UniProt (O95271) Pfam (PF00644) In PDB | HOMO SAPIENS (HUMAN) | TANK1, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 5, ARTD 5, POLY ADP-RIBOSE POLYMERASE 5A, TNKS-1, TRF1-INTERACTING ANKYRIN -RELATED ADP-RIBOSE POLYMERASE, TANKYRASE I, TANK1, ADP-RIBOSYLTRA NSFERASE DIPHTHERIA TOXIN-LIKE 5, ARTD 5, POLY ADP-RIBOSE POLYMERA SE 5A, TNKS-1, TRF1-INTERACTING ANKYRIN -RELATED ADP-RIBOSE POLYME RASE, TANKYRASE I |
2 | H, A, B, C, D... | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
3 | A, C, D | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
4 | G, A, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
5 | G, H, A, B, C... | 3-{4-[(dimethylamino)methyl]phenyl}-5-methoxyisoquinolin-1(2H)-one | non-polymer | 308.4 | 8 | Chemie (92R) |
Sequence modifications
A, B, C, D, E, F, G, H: 1091 - 1325 (UniProt: O95271)
PDB | External Database | Details |
---|---|---|
Met 1068 | - | expression tag |
His 1069 | - | expression tag |
His 1070 | - | expression tag |
His 1071 | - | expression tag |
His 1072 | - | expression tag |
His 1073 | - | expression tag |
His 1074 | - | expression tag |
Ser 1075 | - | expression tag |
Ser 1076 | - | expression tag |
Gly 1077 | - | expression tag |
Val 1078 | - | expression tag |
Asp 1079 | - | expression tag |
Leu 1080 | - | expression tag |
Gly 1081 | - | expression tag |
Thr 1082 | - | expression tag |
Glu 1083 | - | expression tag |
Asn 1084 | - | expression tag |
Leu 1085 | - | expression tag |
Tyr 1086 | - | expression tag |
Phe 1087 | - | expression tag |
Gln 1088 | - | expression tag |
Ser 1089 | - | expression tag |
Met 1090 | - | expression tag |
Ile 1266 | Met 1266 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 235336.7 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 3452.8 | |
All* | Total formula weight | 238789.4 |