Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 122 results
3VQ2
DownloadVisualize
BU of 3vq2 by Molmil
Crystal structure of mouse TLR4/MD-2/LPS complex
Descriptor: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ohto, U, Shimizu, T.
Deposit date:2012-03-17
Release date:2012-05-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Proc.Natl.Acad.Sci.USA, 109, 2012
3W67
DownloadVisualize
BU of 3w67 by Molmil
Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(3,4)-bisphosphate
Descriptor: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate, Alpha-tocopherol transfer protein
Authors:Ohto, U, Satow, Y.
Deposit date:2013-02-11
Release date:2013-05-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
Science, 340, 2013
3WPB
DownloadVisualize
BU of 3wpb by Molmil
Crystal structure of horse TLR9 (unliganded form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
Authors:Ohto, U, Tanji, H, Shimizu, T.
Deposit date:2014-01-11
Release date:2015-02-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPF
DownloadVisualize
BU of 3wpf by Molmil
Crystal structure of mouse TLR9 (unliganded form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Toll-like receptor 9
Authors:Ohto, U, Shimizu, T.
Deposit date:2014-01-11
Release date:2015-02-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.959 Å)
Cite:Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3W68
DownloadVisualize
BU of 3w68 by Molmil
Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(4,5)-bisphosphate
Descriptor: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, ...
Authors:Ohto, U, Satow, Y.
Deposit date:2013-02-11
Release date:2013-05-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
Science, 340, 2013
3WPD
DownloadVisualize
BU of 3wpd by Molmil
Crystal structure of horse TLR9 in complex with inhibitory DNA4084
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*G)-3'), ...
Authors:Ohto, U, Tanji, H, Shimizu, T.
Deposit date:2014-01-11
Release date:2015-02-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPG
DownloadVisualize
BU of 3wpg by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ...
Authors:Ohto, U, Shimizu, T.
Deposit date:2014-01-11
Release date:2015-02-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.246 Å)
Cite:Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPI
DownloadVisualize
BU of 3wpi by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA_super
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*CP*AP*AP*TP*AP*GP*GP*GP*TP*GP*AP*GP*GP*GP*G)-3'), Toll-like receptor 9
Authors:Ohto, U, Shimizu, T.
Deposit date:2014-01-11
Release date:2015-02-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.246 Å)
Cite:Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPE
DownloadVisualize
BU of 3wpe by Molmil
Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer
Descriptor: DNA (5'-D(*CP*AP*TP*GP*AP*CP*GP*TP*TP*CP*CP*T)-3'), Toll-like receptor 9
Authors:Ohto, U, Tanji, H, Shimizu, T.
Deposit date:2014-01-11
Release date:2015-02-11
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPC
DownloadVisualize
BU of 3wpc by Molmil
Crystal structure of horse TLR9 in complex with agonistic DNA1668_12mer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*AP*TP*GP*AP*CP*GP*TP*TP*CP*CP*T)-3'), ...
Authors:Ohto, U, Tanji, H, Shimizu, T.
Deposit date:2014-01-11
Release date:2015-02-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WPH
DownloadVisualize
BU of 3wph by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ...
Authors:Ohto, U, Shimizu, T.
Deposit date:2014-01-11
Release date:2015-02-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.327 Å)
Cite:Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
8HRX
DownloadVisualize
BU of 8hrx by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex
Descriptor: Fab heavy chain from antibody IgG clone number YN9048, Fab light chain from antibody IgG clone number YN9048, PreS1 protein (Fragment), ...
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2022-12-16
Release date:2024-01-17
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
8HRY
DownloadVisualize
BU of 8hry by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex
Descriptor: Fab heavy chain from antibody IgG clone number YN9016, Fab light chain from antibody IgG clone number YN9016, Large S protein (Fragment), ...
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2022-12-16
Release date:2024-01-17
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
3M7O
DownloadVisualize
BU of 3m7o by Molmil
Crystal structure of mouse MD-1 in complex with phosphatidylcholine
Descriptor: (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ...
Authors:Harada, H, Ohto, U, Satow, Y.
Deposit date:2010-03-17
Release date:2010-06-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of mouse MD-1 with endogenous phospholipid bound in its cavity
J.Mol.Biol., 400, 2010
6IF5
DownloadVisualize
BU of 6if5 by Molmil
Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-PHOSPHATE-2',3'-CYCLIC PHOSPHATE, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2018-09-18
Release date:2019-01-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
8WX3
DownloadVisualize
BU of 8wx3 by Molmil
Cryo-EM structure of human SLC15A4 (outward-facing open)
Descriptor: Solute carrier family 15 member 4
Authors:Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2023-10-27
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Cryo-EM structure of human SLC15A4 (outward-facing open)
To Be Published
8WX2
DownloadVisualize
BU of 8wx2 by Molmil
Cryo-EM structure of human SLC15A3 (dimer)
Descriptor: Solute carrier family 15 member 3
Authors:Kasai, S, Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2023-10-27
Release date:2023-12-06
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Cryo-EM structure of human SLC15A3 (outward-facing partially occluded)
To Be Published
8WX4
DownloadVisualize
BU of 8wx4 by Molmil
Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
Descriptor: LEUCINE, LYSINE, Solute carrier family 15 member 4
Authors:Sakaniwa, K, Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2023-10-27
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
To Be Published
6KYA
DownloadVisualize
BU of 6kya by Molmil
Crystal structure of human TLR8 in complex TH1027
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ...
Authors:Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T.
Deposit date:2019-09-17
Release date:2020-05-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
J.Med.Chem., 63, 2020
6LVY
DownloadVisualize
BU of 6lvy by Molmil
Crystal structure of TLR7/Cpd-2 (SM-360320) complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2020-02-06
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
6LW0
DownloadVisualize
BU of 6lw0 by Molmil
Crystal structure of TLR7/Cpd-6 (DSR-139293) complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2020-02-06
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
6LW1
DownloadVisualize
BU of 6lw1 by Molmil
Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form
Descriptor: 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2020-02-06
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
6LVZ
DownloadVisualize
BU of 6lvz by Molmil
Crystal structure of TLR7/Cpd-3 (SM-394830) complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2020-02-06
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
6LVX
DownloadVisualize
BU of 6lvx by Molmil
Crystal structure of TLR7/Cpd-1 (SM-374527) complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2020-02-06
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
5WYZ
DownloadVisualize
BU of 5wyz by Molmil
Crystal structure of human TLR8 in complex with CU-CPT9b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(3-methyl-4-oxidanyl-phenyl)quinolin-7-ol, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2017-01-16
Release date:2017-12-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Small-molecule inhibition of TLR8 through stabilization of its resting state
Nat. Chem. Biol., 14, 2018

219869

건을2024-05-15부터공개중

PDB statisticsPDBj update infoContact PDBjnumon