3W67

Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(3,4)-bisphosphate

Summary for 3W67

Related3W67
DescriptorAlpha-tocopherol transfer protein, (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate, ... (4 entities in total)
Functional Keywordsataxia, vitamin e deficiency, aved, transfer protein, tocopherol, vitamin e, disease mutation, alpha-tocopherol transfer, alpha-tocopherol, phosphatidyl inositol phosphates, transport protein
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm (By similarity) Q8BWP5
Total number of polymer chains4
Total molecular weight126757.4
Authors
Ohto, U.,Satow, Y. (deposition date: 2013-02-11, release date: 2013-05-01, Last modification date: 2013-09-04)
Primary citation
Kono, N.,Ohto, U.,Hiramatsu, T.,Urabe, M.,Uchida, Y.,Satow, Y.,Arai, H.
Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
Science, 340:1106-1110, 2013
PubMed: 23599266 (PDB entries with the same primary citation)
DOI: 10.1126/science.1233508
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.61 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25570.7%5.5%6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 3w67
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Molmil generated image of 3w67
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Molmil generated image of 3w67
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3w67.pdb1.gz [358.64 KB])
Coordinate files for Biological unit (3w67.pdb2.gz [92.08 KB])
Coordinate files for Biological unit (3w67.pdb5.gz [95.15 KB])
Coordinate files for Biological unit (3w67.pdb4.gz [90.68 KB])
Coordinate files for Biological unit (3w67.pdb3.gz [93.2 KB])