Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3W67

Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(3,4)-bisphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001890	biological_process	placenta development
A	0001892	biological_process	embryonic placenta development
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005737	cellular_component	cytoplasm
A	0005770	cellular_component	late endosome
A	0008289	molecular_function	lipid binding
A	0008431	molecular_function	vitamin E binding
A	0009268	biological_process	response to pH
A	0009636	biological_process	response to toxic substance
A	0019842	molecular_function	vitamin binding
A	0042360	biological_process	vitamin E metabolic process
A	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
A	0051180	biological_process	vitamin transport
A	0051452	biological_process	intracellular pH reduction
A	0090212	biological_process	negative regulation of establishment of blood-brain barrier
A	0120009	biological_process	intermembrane lipid transfer
A	0120013	molecular_function	lipid transfer activity
A	1900223	biological_process	positive regulation of amyloid-beta clearance
A	1902936	molecular_function	phosphatidylinositol bisphosphate binding
A	1904036	biological_process	negative regulation of epithelial cell apoptotic process
B	0001890	biological_process	placenta development
B	0001892	biological_process	embryonic placenta development
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005737	cellular_component	cytoplasm
B	0005770	cellular_component	late endosome
B	0008289	molecular_function	lipid binding
B	0008431	molecular_function	vitamin E binding
B	0009268	biological_process	response to pH
B	0009636	biological_process	response to toxic substance
B	0019842	molecular_function	vitamin binding
B	0042360	biological_process	vitamin E metabolic process
B	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
B	0051180	biological_process	vitamin transport
B	0051452	biological_process	intracellular pH reduction
B	0090212	biological_process	negative regulation of establishment of blood-brain barrier
B	0120009	biological_process	intermembrane lipid transfer
B	0120013	molecular_function	lipid transfer activity
B	1900223	biological_process	positive regulation of amyloid-beta clearance
B	1902936	molecular_function	phosphatidylinositol bisphosphate binding
B	1904036	biological_process	negative regulation of epithelial cell apoptotic process
C	0001890	biological_process	placenta development
C	0001892	biological_process	embryonic placenta development
C	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
C	0005737	cellular_component	cytoplasm
C	0005770	cellular_component	late endosome
C	0008289	molecular_function	lipid binding
C	0008431	molecular_function	vitamin E binding
C	0009268	biological_process	response to pH
C	0009636	biological_process	response to toxic substance
C	0019842	molecular_function	vitamin binding
C	0042360	biological_process	vitamin E metabolic process
C	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
C	0051180	biological_process	vitamin transport
C	0051452	biological_process	intracellular pH reduction
C	0090212	biological_process	negative regulation of establishment of blood-brain barrier
C	0120009	biological_process	intermembrane lipid transfer
C	0120013	molecular_function	lipid transfer activity
C	1900223	biological_process	positive regulation of amyloid-beta clearance
C	1902936	molecular_function	phosphatidylinositol bisphosphate binding
C	1904036	biological_process	negative regulation of epithelial cell apoptotic process
D	0001890	biological_process	placenta development
D	0001892	biological_process	embryonic placenta development
D	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
D	0005737	cellular_component	cytoplasm
D	0005770	cellular_component	late endosome
D	0008289	molecular_function	lipid binding
D	0008431	molecular_function	vitamin E binding
D	0009268	biological_process	response to pH
D	0009636	biological_process	response to toxic substance
D	0019842	molecular_function	vitamin binding
D	0042360	biological_process	vitamin E metabolic process
D	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
D	0051180	biological_process	vitamin transport
D	0051452	biological_process	intracellular pH reduction
D	0090212	biological_process	negative regulation of establishment of blood-brain barrier
D	0120009	biological_process	intermembrane lipid transfer
D	0120013	molecular_function	lipid transfer activity
D	1900223	biological_process	positive regulation of amyloid-beta clearance
D	1902936	molecular_function	phosphatidylinositol bisphosphate binding
D	1904036	biological_process	negative regulation of epithelial cell apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE VIV A 301

Chain	Residue
A	SER136
A	SER140
A	PHE158
A	HOH412
A	HOH414
A	HOH415

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3PT A 302

Chain	Residue
A	LYS190
A	VAL191
A	ARG192
A	LEU214
A	LYS217
A	ILE218
A	ARG221
A	HOH413
A	HOH432
A	LEU183
A	THR184
A	ASP185

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE VIV B 301

Chain	Residue
B	SER136
B	SER140
B	PHE158
B	VAL182
B	LEU183
B	PHE187
B	HOH407
B	HOH409
B	HOH410

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3PT B 302

Chain	Residue
B	LEU183
B	THR184
B	ASP185
B	LYS190
B	VAL191
B	ARG192
B	PHE213
B	LYS217
B	ARG221
B	ILE222
B	HOH408
B	HOH428

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE VIV C 301

Chain	Residue
C	TRP122
C	PHE133
C	SER136
C	LEU137
C	SER140
C	PHE158
C	VAL182
C	LEU183
C	PHE187

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3PT C 302

Chain	Residue
C	LEU183
C	THR184
C	LYS190
C	VAL191
C	ARG192
C	LYS217
C	ILE218
C	ARG221

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE VIV D 301

Chain	Residue
D	ALA129
D	SER136
D	LEU137
D	SER140
D	PHE158
D	VAL182
D	LEU183
D	PHE187
D	HOH401

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3PT D 302

Chain	Residue
D	LEU183
D	THR184
D	LYS190
D	VAL191
D	ARG192
D	PHE213
D	ILE218
D	ARG221

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	660
Details	Domain: {"description":"CRAL-TRIO","evidences":[{"source":"PROSITE-ProRule","id":"PRU00056","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23599266","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W67","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23599266","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W68","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)