3W68

Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(4,5)-bisphosphate

Summary for 3W68

Related3w67
DescriptorAlpha-tocopherol transfer protein, (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXYBUTOXY)PROPYL BUTYRATE, ... (6 entities in total)
Functional Keywordsataxia, vitamin e deficiency, aved, transfer protein, tocopherol, vitamin e, disease mutation, alpha-tocopherol transfer, alpha-tocopherol, phosphatidyl inositol phosphates, transport protein
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm (By similarity) Q8BWP5
Total number of polymer chains4
Total molecular weight127383.27
Authors
Ohto, U.,Satow, Y. (deposition date: 2013-02-11, release date: 2013-05-01, Last modification date: 2014-01-29)
Primary citation
Kono, N.,Ohto, U.,Hiramatsu, T.,Urabe, M.,Uchida, Y.,Satow, Y.,Arai, H.
Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
Science, 340:1106-1110, 2013
PubMed: 23599266 (PDB entries with the same primary citation)
DOI: 10.1126/science.1233508
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.05 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.230504.8%11.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3w68
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Molmil generated image of 3w68
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More Biological unit images

Molmil generated image of 3w68
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Molmil generated image of 3w68
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Molmil generated image of 3w68
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3w68.pdb1.gz [362.41 KB])
Coordinate files for Biological unit (3w68.pdb2.gz [93.93 KB])
Coordinate files for Biological unit (3w68.pdb3.gz [95.58 KB])
Coordinate files for Biological unit (3w68.pdb4.gz [92.86 KB])
Coordinate files for Biological unit (3w68.pdb5.gz [92.96 KB])