5WYZ

Crystal structure of human TLR8 in complex with CU-CPT9b

Summary for 5WYZ

Entry DOI	10.2210/pdb5wyz/pdb
Related	5WYX
Descriptor	Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	immune system
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	191063.80
Authors	Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2017-01-16, release date: 2017-12-13, Last modification date: 2020-07-29)
Primary citation	Zhang, S.,Hu, Z.,Tanji, H.,Jiang, S.,Das, N.,Li, J.,Sakaniwa, K.,Jin, J.,Bian, Y.,Ohto, U.,Shimizu, T.,Yin, H. Small-molecule inhibition of TLR8 through stabilization of its resting state Nat. Chem. Biol., 14:58-64, 2018 Cited by PubMed: 29155428 DOI: 10.1038/nchembio.2518 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation