6LVZ

Crystal structure of TLR7/Cpd-3 (SM-394830) complex

Summary for 6LVZ

• Entry DOI: 10.2210/pdb6lvz/pdb
• Descriptor: Toll-like receptor 7, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: tlr7, agonist, immune system
• Biological source: Macaca mulatta (Rhesus macaque)
• Total number of polymer chains: 2
• Total formula weight: 195019.16

Authors

Zhang, Z.,Ohto, U.,Shimizu, T. (deposition date: 2020-02-06, release date: 2020-11-11, Last modification date: 2023-11-29)

• Primary citation: Tojo, S.,Zhang, Z.,Matsui, H.,Tahara, M.,Ikeguchi, M.,Kochi, M.,Kamada, M.,Shigematsu, H.,Tsutsumi, A.,Adachi, N.,Shibata, T.,Yamamoto, M.,Kikkawa, M.,Senda, T.,Isobe, Y.,Ohto, U.,Shimizu, T.; Structural analysis reveals TLR7 dynamics underlying antagonism.; Nat Commun, 11:5204-5204, 2020; PubMed: 33060576; DOI: 10.1038/s41467-020-19025-z

Experimental method

X-RAY DIFFRACTION (2.83 Å)