3WPE

Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer

Summary for 3WPE

• Entry DOI: 10.2210/pdb3wpe/pdb
• Related: 3WPB 3WPC 3WPD 3WPF 3WPG 3WPH 3WPI
• Descriptor: Toll-like receptor 9, DNA (5'-D(*CP*AP*TP*GP*AP*CP*GP*TP*TP*CP*CP*T)-3') (3 entities in total)
• Functional Keywords: leucine rich repeat, receptor, innate immunity, dna binding, glycosylation, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Bos taurus (Bovine); More
• Cellular location: Endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q5I2M5
• Total number of polymer chains: 2
• Total formula weight: 92936.90

Authors

Ohto, U.,Tanji, H.,Shimizu, T. (deposition date: 2014-01-11, release date: 2015-02-11, Last modification date: 2015-05-06)

• Primary citation: Ohto, U.,Shibata, T.,Tanji, H.,Ishida, H.,Krayukhina, E.,Uchiyama, S.,Miyake, K.,Shimizu, T.; Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9; Nature, 520:702-705, 2015; PubMed: 25686612; DOI: 10.1038/nature14138

Experimental method

X-RAY DIFFRACTION (2.38 Å)